Artificial metalloenzymes in a nutshell: the quartet for efficient catalysis

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Paul Ebensperger ◽  
Claudia Jessen-Trefzer
Keyword(s):  
Drug Discovery ◽  
Green Chemistry ◽  
Review Article ◽  
Transition Metal Catalysis ◽  
Bioorthogonal Chemistry ◽  
Metal Catalysis ◽  
Related Research ◽  
Research Fields ◽  
Challenges And Opportunities ◽  
Artificial Metalloenzymes

Abstract Artificial metalloenzymes combine the inherent reactivity of transition metal catalysis with the sophisticated reaction control of natural enzymes. By providing new opportunities in bioorthogonal chemistry and biocatalysis, artificial metalloenzymes have the potential to overcome certain limitations in both drug discovery and green chemistry or related research fields. Ongoing advances in organometallic catalysis, directed evolution, and bioinformatics are enabling the design of increasingly powerful systems that outperform conventional catalysis in a growing number of cases. Therefore, this review article collects challenges and opportunities in designing artificial metalloenzymes described in recent review articles. This will provide an equitable insight for those new to and interested in the field.

Synergistic–cooperative combination of enamine catalysis with transition metal catalysis

2014 ◽  
Vol 50 (33) ◽  
pp. 4272-4284 ◽  
Author(s):  
Yongming Deng ◽  
Siddhartha Kumar ◽  
Hong Wang
Keyword(s):  
Transition Metal ◽  
Review Article ◽  
Transition Metal Catalysis ◽  
Metal Catalysis ◽  
Enamine Catalysis

This review article highlights recent discoveries in synergistic–cooperative combination of enamine catalysis with transition metal catalysis.

scholarly journals Regioselective Functionalization of Quinolines through C-H Activation: A Comprehensive Review

Molecules ◽  
2021 ◽  
Vol 26 (18) ◽  
pp. 5467
Author(s):  
Alessandra Corio ◽  
Christine Gravier-Pelletier ◽  
Patricia Busca
Keyword(s):  
Natural Products ◽  
Transition Metal ◽  
Green Chemistry ◽  
Transition Metal Catalysis ◽  
Synthetic Methods ◽  
Metal Catalysis ◽  
Comprehensive Review ◽  
Metal Catalyzed ◽  
Regioselective Functionalization ◽  
Site Selective

Quinoline is a versatile heterocycle that is part of numerous natural products and countless drugs. During the last decades, this scaffold also became widely used as ligand in organometallic catalysis. Therefore, access to functionalized quinolines is of great importance and continuous efforts have been made to develop efficient and regioselective synthetic methods. In this regard, C-H functionalization through transition metal catalysis, which is nowadays the Graal of organic green chemistry, represents the most attractive strategy. We aim herein at providing a comprehensive review of methods that allow site-selective metal-catalyzed C-H functionalization of quinolines, or their quinoline N-oxides counterparts, with a specific focus on their scope and limitations, as well as mechanistic aspects if that accounts for the selectivity.

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