scholarly journals Loose ends in the eradication of Helicobacter pylori infection

2016 ◽  
Vol 4 (4) ◽  
pp. 178-181
Author(s):  
Armando Peixoto ◽  
Marco Silva ◽  
Rui Gaspar ◽  
Rui Morais ◽  
Rosa Ramalho ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Helicobacter Pylori ◽  
Treatment Failure ◽  
Breath Test ◽  
Eradication Therapy ◽  
Real Life ◽  
Previous Treatment ◽  
Helicobacter Pylori Infection ◽  
Prevention And Treatment

Abstract The eradication of Helicobacter pylori is essential for prevention and treatment of various conditions associated with this infection. However, its effectiveness is limited and influenced by factors linked to the bacteria and the host. In particular, influence of the biotype, smoking, diabetes mellitus, and previous treatment failure in eradication is understudied. Our center proposed to evaluate these aspects in a real life cohort by applying a questionnaire with demographic and lifestyle variables in patients who consecutively underwent urease breath test after the eradication therapy.

A simplified 13C-urea breath test in children with Helicobacter pylori infection: Assessment of eradication therapy and follow-up after treatment

2001 ◽  
Vol 120 (5) ◽  
pp. A579 ◽  
Author(s):  
Atsushi Sawada ◽  
Hitoshi Tajiri ◽  
Norikazu Yoshimura ◽  
Kosuke Kozaiwa ◽  
Shinobu Ida ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Breath Test ◽  
Eradication Therapy ◽  
Urea Breath Test ◽  
Helicobacter Pylori Infection ◽  
13C Urea Breath Test

THE EFFICACY OF THE BISMUTH-CONTAINING QUADRUPLE REGIMEN IN HELICOBACTER PYLORI INFETION

2017 ◽  
pp. 29-34
Author(s):  
Thi Khanh Tuong Tran ◽  
Quoc Bao Vu
Keyword(s):  
Helicobacter Pylori ◽  
Side Effects ◽  
Breath Test ◽  
Eradication Therapy ◽  
Urea Breath Test ◽  
Helicobacter Pylori Infection ◽  
Adherence Rate ◽  
Helicobacter Pylori Eradication ◽  
Colloidal Bismuth Subcitrate ◽  
Helicobacter Pylori Eradication Therapy

Background and Objectives: Bismuth-containing quadruple regimen is recommended as an first-line therapy in areas with high clarithromycin and metronidazole resistance as well as an option for patients who have previously failed to respond to Helicobacter pylori eradication therapy. There have been very few researches on the effectiveness of this regimen on Helicobacter pylori infection treatment in our country. The our study aimed to show the efficacy of Bismuth-based therapy for the treatment of Helicobacter pylori infection. Patients and Methods: The study was carried out on 196 patients with Helicobacter pylori infection. All of patients received a quadruple therapy consisted of Rapeprazole 20 mg bid, Colloidal bismuth subcitrate 120mg qid, Tetracycline 500mg qid and Metronidazole 500mg tid for 14 days. The diagnosis of Helicobacter Pylori infection was performed by Clotest or C13 urea-breath test. Four to eight weeks after completion of therapy, Helicobacter pylori status was rechecked by Clotest or C13 urea-breath test. Results: A total of 196 patients with Helicobacter pylori infection were recruited. The eradication rates of the Bismuth-containing quadruple regimen overall, fornaïve,previously failed to respond to Helicobacter pylori eradication therapy on intention to treat (ITT) and per-protocol (PP) analysis were 97.4-97.3%; 98.3-98.1% and 96.3-96.2%. Side effects occurred in 80.5% of subjects. The common side effects were fatigue, anorexia and nausea. The compliancerate was 98.4%. Conclusions: Bismuth-containing quadruple regimen achieved very highe radication rates. Side effects were common but not serious. The medication adherence rate was high. Key words: Bismuth-containing quadruple regimen, eradication, Helicobacter pylori infection

scholarly journals Noninvasive Diagnostic Tests for Helicobacter Pylori Infection in Children

2005 ◽  
Vol 19 (7) ◽  
pp. 433-439 ◽  
Author(s):  
Sibylle Koletzko
Keyword(s):  
Helicobacter Pylori ◽  
Breath Test ◽  
Clinical Decision Making ◽  
Age Groups ◽  
Eradication Therapy ◽  
High Sensitivity ◽  
Urea Breath Test ◽  
Helicobacter Pylori Infection ◽  
Noninvasive Test ◽  
H Pylori

Noninvasive tests can be used for the initial diagnosis of Helicobacter pylori infection and to monitor the success of eradication therapy. In populations with a low prevalence of H pylori infection (children living in North America and Europe), a high sensitivity is required to make the test valuable for clinical practice. The13C-urea breath test has been validated in children of different age groups in a significant number of infected and noninfected children in several countries and, thus far, is the only noninvasive test that fulfills sensitivity and specificity quality standards. In studies to date, enzyme immunoassays using monoclonal antibodies to detect H pylori antigen in stool provide excellent results, but the number of children tested, particularly post-treatment, is not sufficient to recommend the test. All other noninvasive stool tests or methods based on the detection of specific antibodies in serum, whole blood, urine or saliva have limited accuracy in comparison with the13C-urea breath test. Therefore, these tests cannot be recommended for clinical decision making in pediatric patients.

A 13 C-urea breath test in children with Helicobacter pylori infection: assessment of eradication therapy and follow-up after treatment

2001 ◽  
Vol 36 (9) ◽  
pp. 606-611 ◽  
Author(s):  
Norikazu Yoshimura ◽  
Hitoshi Tajiri ◽  
Atsushi Sawada ◽  
Kosuke Kozaiwa ◽  
Shinobu Ida ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Breath Test ◽  
Eradication Therapy ◽  
Urea Breath Test ◽  
Helicobacter Pylori Infection

scholarly journals Diabetes mellitus as a cause of inefficiency of eradication therapy of Helicobacter pylori infection: a systematized literature review

2019 ◽  
pp. 32-38
Author(s):  
L. G. Bektemirova ◽  
D. N. Andreev ◽  
A. M. Mkrtumyan ◽  
D. T. Dicheva
Keyword(s):  
Diabetes Mellitus ◽  
Helicobacter Pylori ◽  
Eradication Therapy ◽  
Weighted Average ◽  
Interdisciplinary Approach ◽  
Helicobacter Pylori Infection ◽  
Efficacy And Safety ◽  
Patients With Diabetes ◽  
The Russian Federation ◽  
Upper Gastrointestinal

Diabetes mellitus (DM) is a moderately common issue both in the world and in the Russian Federation. Consequently, an interdisciplinary approach to studying the characteristics of the course and therapeutic management of gastroenterological pathology in this group of patients, in particular,Helicobacter pyloriinfection, which is associated with a whole range of diseases of the upper gastrointestinal tract, is of special interest. The article provides a systematic review of foreign and domestic studies of the efficacy and safety of various eradication regimens for Helicobacter pylori infection in patients with diabetes. In general, it was shown that the weighted average efficiency of eradication in people with diabetes was 17.7–23.8% lower than in people, who did not suffered from that disease.

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