Cord blood nucleated red blood cell level: is it a predictive marker for neonatal jaundice?

2018 ◽  
Vol 42 (5) ◽  
pp. 171-175
Author(s):  
Alper Orhon ◽  
Hatice Topal ◽  
Nilay Hakan ◽  
Esra Arun Ozer
Keyword(s):  
Blood Cell ◽  
Cord Blood ◽  
Red Blood Cell ◽  
Neonatal Jaundice ◽  
Newborn Infants ◽  
Predictive Marker ◽  
Study Groups ◽  
Cell Level ◽  
Healthy Newborn ◽  
Nucleated Red Blood Cell

AbstractBackgroundThe aim of this study was to evaluate if the cord blood nucleated red blood cell (nRBC) levels can predict the development of hyperbilirubinemia in healthy neonates.MethodsAll healthy newborn infants born after 35 or more weeks of gestation at our hospital between January 2016 and April 2017 were included. The levels of nRBC were counted in umbilical cord blood samples. Neonates were grouped into two study groups based on the presence or absence of neonatal jaundice.ResultsThe study included overall 149 eligible newborn infants. The levels of nRBC and absolute nRBC count showed statistically significant differences between newborns with or without jaundice (p=0.01 and 0.02, respectively).ConclusionsWe suggest that increased nRBC counts in cord blood may be a predictive marker for hyperbilirubinemia in healthy newborn infants.

scholarly journals Nucleated red blood cell in cord blood as a marker of perinatal asphyxia

2013 ◽  
Vol 2 (4) ◽  
pp. 179 ◽  
Author(s):  
Manjusha Goel ◽  
Rashmi Dwivedi ◽  
Poorva Gohiya ◽  
Deeparaj Hegde
Keyword(s):  
Blood Cell ◽  
Cord Blood ◽  
Red Blood Cell ◽  
Perinatal Asphyxia ◽  
Nucleated Red Blood Cell

Are Placental Chorionic Capillary Nucleated Red Blood Cell Counts Useful Compared to Umbilical Cord Blood Tests?

2006 ◽  
Vol 22 (2) ◽  
pp. 121-123
Author(s):  
Joan M. McCarthy ◽  
Enid Gilbert-Barness ◽  
John C.M. Tsibris ◽  
William N. Spellacy
Keyword(s):  
Blood Cell ◽  
Cord Blood ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Red Blood Cell ◽  
Blood Tests ◽  
Cell Counts ◽  
Blood Cell Counts ◽  
Nucleated Red Blood Cell

Umbilical Cord Knots and Cord Blood Gases, Erythropoietin and Nucleated Red Blood Cell Levels: A Study of Possible Chronic Fetal Hypoxia

2012 ◽  
Vol 32 (2) ◽  
pp. 158-161 ◽  
Author(s):  
William N. Spellacy ◽  
Enid Gilbert-Barness ◽  
John C.M. Tsibris ◽  
Katheryne L. Downes
Keyword(s):  
Blood Cell ◽  
Cord Blood ◽  
Umbilical Cord ◽  
Red Blood Cell ◽  
Blood Gases ◽  
Fetal Hypoxia ◽  
Nucleated Red Blood Cell

Implementing a routine flow cytometry assay for nucleated red blood cell counts in cord blood units

2016 ◽  
Vol 38 (6) ◽  
pp. 600-609 ◽  
Author(s):  
C. Simard ◽  
M. Cloutier ◽  
C. Jobin ◽  
J. Dion ◽  
D. Fournier ◽  
...  
Keyword(s):  
Flow Cytometry ◽  
Blood Cell ◽  
Cord Blood ◽  
Red Blood Cell ◽  
Flow Cytometry Assay ◽  
Cell Counts ◽  
Blood Cell Counts ◽  
Nucleated Red Blood Cell

scholarly journals Significance of cord blood nucleated red blood cell count in pregnancies complicated by preeclampsia as a marker for intra uterine growth restriction

2020 ◽  
Vol 7 (8) ◽  
pp. 1723
Author(s):  
Priyanka Krishna ◽  
Karthik R. ◽  
Adarsh E.
Keyword(s):  
Blood Cell ◽  
Cord Blood ◽  
Red Blood Cell ◽  
Growth Restriction ◽  
Control Group ◽  
P Value ◽  
Potential Marker ◽  
Uterine Growth ◽  
Intra Uterine Growth Restriction ◽  
Nucleated Red Blood Cell

Background: Preeclampsia is a pregnancy-specific syndrome of reduced organ perfusion secondary to vasospasm and endothelial activation which is typically characterized by hypertension, proteinuria, edema and fetal compromise which is a leading cause of intra uterine growth restriction (IUGR).  Elevated nucleated red blood cell (NRBC) count is introduced as a potential marker of intra-uterine growth restriction (IUGR) hence determination of NRBC counts is essentially helpful in predicting short term neurodevelopment outcome. Objective of the study Elevated nucleated red blood cell (NRBC) count is introduced as a potential marker of intra-uterine growth restriction (IUGR) in term babies born to preeclamptic mothersMethods: A cross sectional study conducted in a tertiary care hospital to evaluate the significance of cord blood NRBC count in term neonates born with pregnancy complicated by preeclampsia. It included 60 healthy mothers (control group) and 60 mothers with PIH. Collected data was analysed with SPSS software.Results: The nucleated red blood cell in cord blood of newborns in preeclampsia group was significantly higher than in the control group (p value 0.013). IUGR is significantly higher in PIH group (p value 0.008).Conclusions: From the observed data it is concluded that IUGR is an important cause of perinatal morbidity and mortality. The commonest maternal cause for IUGR was pregnancy induced hypertension. The other contributing factors were anemia, lack of awareness (unregistered, unbooked cases) among mothers, poor maternal nutrition and poor weight gain during pregnancy.  Infants of preeclamptic women have higher nucleated red blood cell count at birth than control which means that preeclampsia may produce an erythropoietic response in the fetus. The positive correlation between cord nucleated red blood cell counts in preeclamptic patients and control group indicates that may be the hypoperfused placenta plays a role in this correlation.

Oxygen Consumption in Platelets of Newborn Infants before and after Stimulation by Thrombin.

1976 ◽  
Vol 35 (03) ◽  
pp. 712-716 ◽  
Author(s):  
D. Del Principe ◽  
G Mancuso ◽  
A Menichelli ◽  
G Maretto ◽  
G Sabetta
Keyword(s):  
Oxygen Consumption ◽  
Cord Blood ◽  
Umbilical Cord ◽  
Newborn Infant ◽  
Umbilical Cord Blood ◽  
Newborn Infants ◽  
O2 Consumption ◽  
Adult Control ◽  
Healthy Newborn ◽  
Before And After

SummaryThe authors compared the oxygen consumption in platelets from the umbilical cord blood of 36 healthy newborn infants with that of 27 adult subjects, before and after thrombin addition (1.67 U/ml). Oxygen consumption at rest was 6 mμmol/109/min in adult control platelets and 5.26 in newborn infants. The burst in oxygen consumption after thrombin addition was 26.30 mμmol/109/min in adults and 24.90 in infants. Dinitrophenol did not inhibit the burst of O2 consumption in platelets in 8 out of 10 newborn infants, while the same concentration caused a decrease in 9 out of 10 adult subjects. Deoxyglucose inhibited the burst in O2 consumption in newborn infant and adult platelets by about 50%. KCN at the concentration of 10−4 M completely inhibited basal oxygen consumption but did not completely inhibit the burst after thrombin. At the concentration of 10−3 M, it inhibited both basal O2 consumption and the burst in infants and adult subjects.

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