Emulsion synthesis of dicalcium phosphate particles for the preparation of calcium phosphate cements with improved compressive strengths and reduced setting times

nano Online ◽  
2016 ◽  
Author(s):  
Sabine Wächter ◽  
Claus Moseke ◽  
Jürgen Groll ◽  
Uwe Gbureck
Keyword(s):  
Calcium Phosphate ◽  
Dicalcium Phosphate ◽  
Calcium Phosphate Cements ◽  
Setting Times ◽  
Emulsion Synthesis

Emulsion synthesis of dicalcium phosphate particles for the preparation of calcium phosphate cements with improved compressive strengths and reduced setting times

2013 ◽  
Vol 14 (1-2) ◽  
Author(s):  
Sabine Wächter ◽  
Claus Moseke ◽  
Jürgen Groll ◽  
Uwe Gbureck
Keyword(s):  
Calcium Phosphate ◽  
Dicalcium Phosphate ◽  
Calcium Phosphate Cements ◽  
Setting Times ◽  
Emulsion Synthesis

AbstractThis study aimed to produce nanosized secondary calcium phosphate powders (CaHPO

Preparation of Calcium Phosphate Cement Utilizing Dicalcium Phosphate Dihydrate and Calcium Carbonate

2014 ◽  
Vol 608 ◽  
pp. 280-286
Author(s):  
Nudthakarn Kosachan ◽  
Angkhana Jaroenworaluck ◽  
Sirithan Jiemsirilers ◽  
Supatra Jinawath ◽  
Ron Stevens
Keyword(s):  
Calcium Carbonate ◽  
Calcium Phosphate ◽  
Calcium Phosphate Cement ◽  
Raw Materials ◽  
Setting Time ◽  
Dicalcium Phosphate ◽  
Dicalcium Phosphate Dihydrate ◽  
Cement Pastes ◽  
Setting Times ◽  
Phosphate Dihydrate

Calcium phosphate cement has been widely used as a bone substitute because of its chemical similarity to natural bone. In this study, calcium phosphate cement was prepared using dicalcium phosphate dihydrate (CaHPO4.2H2O) and calcium carbonate (CaCO3) as starting raw materials. The cement pastes were mixed and the chemistry adjusted with two different aqueous solutions of sodium hydroxide (NaOH) and disodium hydrogen phosphate (Na2HPO4). Concentrations of the solution were varied in the range 0.5 to 5.0 mol/L with the ratio of solid/liquid = 2 g/ml. The cement paste was then poured into a silicone mold having a diameter of 10 mm and a height 15 mm. Setting times for the cement were measured using a Vicat apparatus. XRD, FT-IR, and SEM techniques were used to characterize properties and microstructure of the cement. From the experimental results, it is clear that different concentrations of Na2HPO4 and NaOH have affected the setting times of the cement. The relationship between concentration of NaOH and Na2HPO4 and setting time, including final properties of the cement, is discussed.

New Characterization of Setting Times of Alkali Containing Calcium Phosphate Cements by Using an Automatically Working Device According to Gillmore Needle Test

2006 ◽  
Vol 309-311 ◽  
pp. 825-828 ◽  
Author(s):  
Georg Berger ◽  
Christian Ullner ◽  
Gerhard Neumann ◽  
Heidi Marx
Keyword(s):  
Calcium Phosphate ◽  
Cement Paste ◽  
Standard Test ◽  
Test Method ◽  
Calcium Phosphate Cements ◽  
Standard Test Method ◽  
Setting Times ◽  
Hydraulic Cement ◽  
Working Device

This paper presents equipment for the measurement of initial as well as final setting times of calcium phosphate cements containing alkali to achieve higher solubility. Until now, the selfsetting process of cements also if alkali is integrated has been tested by using the “standard test method for time of setting of hydraulic-cement paste by Gillmore needles” in accordance to ASTM C 266 – 99. This procedure needs high man power and, furthermore, the results have been markedly influenced by individual experiences that are incorporated in the criterion “without appreciable indentation”.

scholarly journals Effect of the Addition of Alginate and/or Tetracycline on Brushite Cement Properties

Molecules ◽  
2021 ◽  
Vol 26 (11) ◽  
pp. 3272
Author(s):  
Claudia Morilla ◽  
Elianis Perdomo ◽  
Ana Karla Hernández ◽  
Ramcy Regalado ◽  
Amisel Almirall ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Calcium Phosphate ◽  
Cell Viability ◽  
Sodium Alginate ◽  
Clinical Application ◽  
Bone Defect ◽  
Dicalcium Phosphate ◽  
Release System ◽  
Calcium Phosphate Cements ◽  
Compression Resistance

Calcium phosphate cements have the advantage that they can be prepared as a paste that sets in a few minutes and can be easily adapted to the shape of the bone defect, which facilitates its clinical application. In this research, six formulations of brushite (dicalcium phosphate dihydrated) cement were obtained and the effect of the addition of sodium alginate was analyzed, such as its capacity as a tetracycline release system. The samples that contain sodium alginate set in 4 or 5 min and showed a high percentage of injectability (93%). The cements exhibit compression resistance values between 1.6 and 2.6 MPa. The drug was released in a range between 12.6 and 13.2% after 7 days. The antimicrobial activity of all the cements containing antibiotics was proven. All samples reached values of cell viability above 70 percent. We also observed that the addition of the sodium alginate and tetracycline improved the cell viability.

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