6-(Hydroxythio) carbonyIpyridin-2-carbonsäure und Pyridin-2-carbon- säure-6-monothiocarbonsäure als biosynthetische Zwischenstufen bei der Bildung von Pyridin-2,6-di(monothiocarbonsäure) aus Pyridin-2,6- dicarbonsäure [1] / 6-(Hydroxythio)carbonylpyridine-2-carboxylic Acid and Pyridine-2-carboxylic Acid-6- monothiocarboxylic Acid as Interm ediates in the Biosynthesis of Pyridine-2,6-di(monothiocarboxylic Acid) from Pyridine-2,6-dicarboxylic Acid [1]

1986 ◽  
Vol 41 (7-8) ◽  
pp. 691-694 ◽  
Author(s):  
U. Hildebrand ◽  
K. Taraz ◽  
H. Budzikiewicz
Keyword(s):  
Carboxylic Acid ◽  
Dicarboxylic Acid ◽  
Pseudomonas Putida ◽  
Feeding Experiments ◽  
First Time

Abstract It is shown by feeding experiments with [3-2H]pyridine-2,6 -dicarboxylic acid that 6 -(hydroxythio)carbonylpyridine-2-carboxylic acid and pyridine-2 -carboxylic acid-6-m onothiocarboxylic acid are intermediates in the biosynthesis of pyridine-2,6 -di(monothiocarboxylic acid) from pyridine-2,6 -dicarboxylic acid produced by Pseudomonas putida. Thus the series of biosynthetic steps - COOH → - CO - SOH → COSH has been demonstrated for the first time.

scholarly journals Regioselective Base-induced Condensations of Acrylic Acid Derivatives

1999 ◽  
Vol 23 (3) ◽  
pp. 174-175
Author(s):  
E. Abdel-Ghani
Keyword(s):  
Carboxylic Acid ◽  
Acrylic Acid ◽  
Dicarboxylic Acid ◽  
Ethyl Acetoacetate ◽  
Tobacco Necrosis Virus ◽  
Necrosis Virus ◽  
Antiviral Activities

The orientation of cyclization of the reaction of methyl aroylacrylate (1) and aroylacrylic acid (8) with ethyl acetoacetate and/or thiourea leading to the formation of 4-aroylmethylcyclopentane-1,3-dione (2) 5-aryl-3-oxocyclohexene-1,2-dicarboxylic acid (9), 2-imino-5-aroylmethylthiazolidin-4-one (11) and 6-aryl-2-sulfonylpyrimidine-4-carboxylic acid (14) depends on the medium employed; some compounds show moderate antiviral activities against tobacco necrosis virus.

Metabolism of syringyl lignin-derived compounds in Pseudomonas putida enables convergent production of 2-pyrone-4,6-dicarboxylic acid

2021 ◽  
Author(s):  
Sandra Notonier ◽  
Allison Z. Werner ◽  
Eugene Kuatsjah ◽  
Linda Dumalo ◽  
Paul E. Abraham ◽  
...  
Keyword(s):  
Dicarboxylic Acid ◽  
Pseudomonas Putida ◽  
Syringyl Lignin

Design, synthesis and evaluation of structurally diverse ortho-acylphenol-diindolylmethane hybrids as anticancer agents

2022 ◽  
Author(s):  
Zhi-Gang Yin ◽  
Xiong-Wei Liu ◽  
Hui-Juan Wang ◽  
Min Zhang ◽  
Xiong-Li Liu ◽  
...  
Keyword(s):  
Carboxylic Acid ◽  
Anticancer Agents ◽  
Nucleophilic Addition ◽  
Ring Opening ◽  
Building Blocks ◽  
Efficient Synthesis ◽  
Design Synthesis ◽  
Pyrone Ring ◽  
Ring Opening Reaction ◽  
First Time

A highly efficient synthesis of structurally diverse ortho-acylphenol–diindolylmethane hybrids 3 using carboxylic acid-activated chromones as versatile synthetic building blocks is reported here for the first time, through 1,4-nucleophilic addition and followed by a decarboxylation and pyrone ring opening reaction process.

Umwandlungen von Phenazinen in Pseudomonas aureofaciens [1] / Transformations of Phenazines in Pseudomonas aureofaciens

1983 ◽  
Vol 38 (7-8) ◽  
pp. 539-543 ◽  
Author(s):  
A. Römer ◽  
E. Lange
Keyword(s):  
Carboxylic Acid ◽  
Dicarboxylic Acid ◽  
Methyl Derivative ◽  
Pseudomonas Aureofaciens ◽  
Acid Methyl

Transformation of phenazines in Pseudomonas aureofaciens were investigated with deuterated phenazine-1-carboxylic acid, 2-hydroxyphenazine-1-carboxylic acid, phenazine-1,6-dicarboxylic acid, methyl phenazine-1-carboxylate, dimethyl phenazine-1,6-dicarboxylate, and its mono methyl derivative. It was shown that hydroxylation and decarboxylation of phenazine-1-carboxylic acid gave rise to the variety of phenazines isolated from this strain.

2,3,9-Trihydroxyphenazin-l-carbonsäure – ein unter Berylliumeinwirkung gebildetes neues Phenazinderivat aus Pseudomonas fluorescens [1] / 2,3,9-Trihydroxyphenazine- l -carboxylic Acid — a New Phenazine Derivative from Pseudomonas fluorescens Grown under Beryllium Stress [1]

1990 ◽  
Vol 45 (4) ◽  
pp. 552-556 ◽  
Author(s):  
K. Taraz ◽  
E. M. Schaffner ◽  
H. Budzikiewicz ◽  
H. Korth ◽  
G. Pulverer
Keyword(s):  
Carboxylic Acid ◽  
Iron Deficiency ◽  
Dicarboxylic Acid ◽  
Pseudomonas Fluorescens ◽  
Structure Elucidation ◽  
Culture Medium ◽  
Phenazine Derivative

In addition to phenazine, phenazine-1-carboxylic acid, phenazine-1,6-dicarboxylic acid and 2,9-dihydroxyphenazine-1-carboxylic acid a new compound, viz. 2,3,9-trihydroxyphenazine-1-carboxylic acid could be isolated from the culture medium of Pseudomonas fluorescens grown under iron deficiency with beryllium added to the culture medium. Its structure elucidation is described.

scholarly journals Late-Stage β-C(sp3)–H Deuteration of Carboxylic Acids

2021 ◽  
Author(s):  
Alexander Uttry ◽  
Sourjya Mal ◽  
Manuel van Gemmeren
Keyword(s):  
Carboxylic Acid ◽  
Carboxylic Acids ◽  
Late Stage ◽  
Bioactive Molecules ◽  
Wide Range ◽  
Catalyst Systems ◽  
First Time

Carboxylic acid moieties are highly abundant in bioactive molecules. In this study we describe the late-stage β-C(sp<sup>3</sup>)–H deuteration of free carboxylic acids. Based on our finding that the C–H activation with our catalyst systems is reversible, the de-deuteration process was first optimized. The resulting conditions involve ethylenediamine-based ligands, which, amongst other positions, for the first time enables the functionalization of non-activated methylene β-C(sp<sup>3</sup>)–H bonds and can be used to achieve the desired deuteration when using a deuterated solvent. The reported method allows for the functionalization of a wide range of free carboxylic acids with diverse substitution patterns, as well as the late-stage deuteration of bioactive molecules and related frameworks.

Luminescence studies of uranyl-aliphatic dicarboxylic acid complexes in acetonitrile medium

2020 ◽  
Vol 108 (5) ◽  
pp. 361-373 ◽  
Author(s):  
Siuli Maji ◽  
Satendra Kumar ◽  
Sundararajan Kalyanasundaram
Keyword(s):  
Dicarboxylic Acid ◽  
Adipic Acid ◽  
Glutaric Acid ◽  
Luminescence Spectra ◽  
Pimelic Acid ◽  
Effect Of Solvent ◽  
Solvent Water ◽  
Vis Spectroscopy ◽  
First Time ◽  
Acetonitrile Medium

AbstractThe uranyl (UO22+)-aliphatic dicarboxylic acid complexes are studied by luminescence and UV-Vis spectroscopy in acetonitrile (MeCN) medium. The ligands used are malonic acid (MA), succinic acid (SA), glutaric acid (GA), adipic acid (AA) and pimelic acid (PA). The complexes of UO22+ with the above ligands showed well resolved luminescence spectra at pH 4.0 with M/L = 5. Both luminescence and UV-Vis spectra indicated the formation of 1:2 and 1:3 complexes of UO22+ with MA and GA, AA, PA, respectively. DFT computations indicated the formation of 1:2 chelate complex of UO22+ with MA and two types of 1:3 complexes of UO22+ with SA, GA, AA and PA. Furthermore, the effect of solvent (water and acetonitrile) on the UO22+-ligand complexes has been performed using COSMO model. The present study demonstrates, for the first time, the formation of tris complexes of uranyl with these ligands in acetonitrile medium.

scholarly journals New Stable Manganese(III) Chelates of Some Pyridine Carboxylic Acids

1981 ◽  
Vol 36 (10) ◽  
pp. 1270-1272 ◽  
Author(s):  
Saktiprosad Ghosh ◽  
Pranab K. Ray ◽  
Tapas K. Bandyopadhyay ◽  
Amal K. Deb
Keyword(s):  
Carboxylic Acid ◽  
Dicarboxylic Acid ◽  
Carboxylic Acids ◽  
Tricarboxylic Acid ◽  
Pyridine Carboxylic ◽  
Physicochemical Methods

Abstract The syntheses of three new and unusually stable Mn(III) complexes of pyridine-2-carboxylic acid, pyridine-2,6-dicarboxylic acid and pyridine-2,4,6-tricarboxylic acid and their characterisation by various standard physicochemical methods is reported

scholarly journals A New Bithiophene from the Root of Echinops grijsii

2015 ◽  
Vol 10 (12) ◽  
pp. 1934578X1501001 ◽  
Author(s):  
Fang-Pin Chang ◽  
Chien-Chih Chen ◽  
Hui-Chi Huang ◽  
Sheng-Yang Wang ◽  
Jih-Jung Chen ◽  
...  
Keyword(s):  
Carboxylic Acid ◽  
Cell Line ◽  
Natural Source ◽  
Inflammatory Activity ◽  
Raw 264.7 ◽  
Raw 264.7 Cell ◽  
Anti Inflammatory ◽  
First Time ◽  
Raw 264.7 Cell Line

A new bithiophene, 5-(4-hydroxy-3-methoxy-1-butyny)-2,2′-bithiophene (1), and sixteen known thiophenes: 2-(3,4-dihydroxybut-1-ynyl)-5-(penta-1,3-diynyl)thiophene (2), α-terthienyl (3), 5-(3,4-dihydroxybut-1-ynyl)-2,2′-bithiophene (4), 5-acetyl-2,2′-bithiophene (5), 5-formyl-2,2′-bithiophene (6), methyl 2,2′-bithiophene-5-carboxylate (7), 5-(but-3-en-1-ynyl)-2,2′-bithiophene (8), 5-(4-isovaleroyloxybut-1-ynyl)-2,2′-bithiophene (9), cardopatine (10), isocardopatine (11), 5-(3-hydroxy-4-isovaleroyloxybut-1-ynyl)-2,2′-bithiophene (12), 5-(3-hydroxymethyl-3-isovaleroyloxyprop-1-ynyl)-2,2′-bithiophene (13), 5-(4-hydroxy-1-butynyl)-2,2′-bithiophene (14), 5-(4-acetoxy-1-butynl)-2,2′-bithiophene (15), 2,2′-bithiophene-5-carboxylic acid (16) and 2-(4-hydroxybut-1-ynyl)-5-(penta-1,3-diynyl)thiophene (17) were isolated from the roots of Echinops grijisii Hance. Among them, compounds 6, 7 and 16 were isolated from a natural source for the first time. Compounds 2, 4 and 14 exhibited significant anti-inflammatory activity against nitrite of LPS-stimulated production in the RAW 264.7 cell line.

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