scholarly journals The Effect of the Fractional Carbon Dioxide Laser on Improving Minoxidil Delivery for the Treatment of Androgenetic Alopecia

2019 ◽  
Vol 11 (1) ◽  
pp. 29-36
Author(s):  
Manal Salah ◽  
Nevien Samy ◽  
Marwa Mohamed Fawzy ◽  
Abdel Razik Farrag ◽  
Hany Shehata ◽  
...  

Introduction: Recently, laser treatment for hair loss has become very popular. Laser-assisted drug delivery (LAD) is an evolving technology with potentially broad clinical applications. This work aims at inspecting the effect of the fractional carbon dioxide laser (CO2 ) on improving the delivery of minoxidil in patients with androgenetic alopecia and detecting the role of the fractional CO2 laser in its treatment. Methods: We enrolled 45 Egyptians with male androgenetic alopecia (MAGA); clinical grading was assessed based on Norwood-Hamilton classification. The patients were divided into 3 groups: the first group (combined group) received the fractional CO2 laser session followed by topical application of minoxidil and also in between sessions; the second group received fractional CO2 laser sessions only and 6 sessions with 2-week intervals were performed; the third group applied topical minoxidil only for 3 months. Global photographs and dermoscopic assessments were performed before treatment and 3 months after the treatment. Results: Several dermoscopic findings were detected, including peripilar sign, hair diversity, yellow spot, white dots, and arborizing red lines. The number of double hair units significantly increased after the treatment in the combined group. The mean number of hair after the treatment in the 3 groups significantly increased, mostly in the combined group. The hair thickness (thin & thick) significantly increased after the treatment in the combined group and the fractional group; however, in the minoxidil group, only thin hair thickness increased. In all the 3 groups, there was a significant improvement in hair count and thickness. Conclusion: The ablative fractional CO2 laser alone or combined with minoxidil may serve as an additional treatment for MAGA.

2016 ◽  
Vol 2016 ◽  
pp. 1-7 ◽  
Author(s):  
Farahnaz Fatemi Naeini ◽  
Shadi Behfar ◽  
Bahareh Abtahi-Naeini ◽  
Shima Keyvan ◽  
Mohsen Pourazizi

Background. A consistent treatment has not been proposed for treatment of Striae Alba (SA). The present study was designed to compare the fractionated microneedle radiofrequency (FMR) alone and in combination with fractional carbon dioxide laser (FMR + CO2) in the treatment of SA.Methods. Forty-eight pairs of SA from six patients were selected. Right or left SAs were randomly assigned to one of the treatment groups. The surface area of the SA before and after treatment and clinical improvement using a four-point scale were measured at the baseline, after one and three months.Results. The mean age of the patients was30.17±5.19years. The mean difference of the surface area between pre- and posttreatment in the FMR + CO2group was significantly higher than that in the FMR group (p=0.003). Clinical improvement scales showed significantly higher improvement in the FMR + CO2group than in the FMR group in the first and second follow-up (p=0.002and 0.004, resp.). There were no major persistence side-effects in both groups.Conclusions. The results showed that FMR + CO2laser was more effective than FMR alone in the treatment of SA.


Author(s):  
Neera R. Nathan ◽  
Daniel M. O'Connor ◽  
Jonathan J. Lee ◽  
Kristine M. Cornejo ◽  
Jennifer K. Tan ◽  
...  

2019 ◽  
Vol 58 (10) ◽  
pp. 1212-1222 ◽  
Author(s):  
Rania S. Abou Eitta ◽  
Aisha A. Ismail ◽  
Rania A. Abdelmaksoud ◽  
Naser A. Ghezlan ◽  
Radwa A. Mehanna

2016 ◽  
Vol 2016 ◽  
pp. 1-6 ◽  
Author(s):  
Vasanop Vachiramon ◽  
Pattarin Anusaksathien ◽  
Silada Kanokrungsee ◽  
Kumutnart Chanprapaph

Objective. Keratosis pilaris (KP) is a common condition which can frequently be cosmetically disturbing. Topical treatments can be used with limited efficacy. The objective of this study is to evaluate the effectiveness and safety of fractional carbon dioxide (CO2) laser for the treatment of KP.Patients and Methods. A prospective, randomized, single-blinded, intraindividual comparative study was conducted on adult patients with KP. A single session of fractional CO2laser was performed to one side of arm whereas the contralateral side served as control. Patients were scheduled for follow-up at 4 and 12 weeks after treatment. Clinical improvement was graded subjectively by blinded dermatologists. Patients rated treatment satisfaction at the end of the study.Results. Twenty patients completed the study. All patients stated that the laser treatment improved KP lesions. At 12-week follow-up, 30% of lesions on the laser-treated side had moderate to good improvement according to physicians’ global assessment (p=0.02). Keratotic papules and hyperpigmentation appeared to respond better than the erythematous component. Four patients with Fitzpatrick skin type V developed transient pigmentary alteration.Conclusions. Fractional CO2laser treatment may be offered to patients with KP. Dark-skinned patients should be treated with special caution.


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