scholarly journals The therapeutic effect of autologous bone marrow mesenchymal stem cells to prevent the progress of chronic allograft nephropathy

2018 ◽  
Vol 8 (1) ◽  
pp. 1-5 ◽  
Author(s):  
Farhad Gholami ◽  
Ali Ghasemi ◽  
Ahmad Reza Bahrami ◽  
Hamid Reza Bidkhouri ◽  
Hojat Naderi Mishkin ◽  
...  
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Regenerative Medicine ◽  
Turning Point ◽  
Autologous Bone Marrow ◽  
Regeneration Ability ◽  
Paracrine Effects ◽  
Marrow Mesenchymal Stem Cells ◽  
Autologous Bone

Progenitor cells or mesenchymal stem cells are new cells, with renovation and regeneration ability and tissues repair. In recent years, administration of stem cells has been introduced to treat a variety of diseases including chronic allograft injury (CAI). It seems that stem cells can create a turning point in regenerative medicine through repair, replacement with damaged tissues or with their paracrine effects.

scholarly journals Meta-Analysis and Evidence Base for the Efficacy of Autologous Bone Marrow Mesenchymal Stem Cells in Knee Cartilage Repair: Methodological Guidelines and Quality Assessment

2019 ◽  
Vol 2019 ◽  
pp. 1-15 ◽  
Author(s):  
Mohamed E. Awad ◽  
Khaled A. Hussein ◽  
Inas Helwa ◽  
Mohamed F. Abdelsamid ◽  
Alexandra Aguilar-Perez ◽  
...  
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Cartilage Repair ◽  
Meta Analysis ◽  
Autologous Bone Marrow ◽  
Knee Cartilage ◽  
Marrow Mesenchymal Stem Cells ◽  
Autologous Bone ◽  
Coleman Methodology Score

The aim of this study is to review all the published clinical trials on autologous bone marrow mesenchymal stem cells (BM-MSCs) in the repair of cartilage lesions of the knee. We performed a comprehensive search in three electronic databases: PubMed, Medline via Ovid, and Web of Science. A systematic review was conducted according to the guidelines of PRISMA protocol and the Cochrane Handbook for Systematic Reviews of Interventions. The modified Coleman methodology score was used to assess the quality of the included studies. Meta-analysis was conducted to estimate the effect size for Pain and function change after receiving BM-MSCs. Thirty-three studies—including 724 patients of mean age 44.2 years—were eligible. 50.7% of the included patients received cultured BM-MSCs for knee cartilage repair. There was improvement in the MINORS quality score over time with a positive correlation with the publication year. Meta-analysis indicated better improvement and statistical significance in the Visual Analog Scale for Pain, IKDC Function, Tegner Activity Scale, and Lysholm Knee Score after administration of noncultured BM-MSCs when compared to evaluation before the treatment. Meanwhile, there was a clear methodological defect in most studies with an average modified Coleman methodology score (MCMS) of 55. BM-MSCs revealed a clinically relevant improvement in pain, function, and histological regeneration.

Angiogenesis in Rat Uterine Cicatrix after Injection of Autologous Bone Marrow Mesenchymal Stem Cells

2011 ◽  
Vol 150 (6) ◽  
pp. 756-761 ◽  
Author(s):  
I. V. Maiborodin ◽  
N. V. Yakimova ◽  
V. A. Matveyeva ◽  
O. G. Pekarev ◽  
E. I. Maiborodina ◽  
...  
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Autologous Bone Marrow ◽  
Marrow Mesenchymal Stem Cells ◽  
Autologous Bone
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