Evaluating Locally Developed Interventions to Promote PrEP Among Racially/Ethnically Diverse Transgender Women in the United States: A Unique CDC Initiative

2021 ◽  
Vol 33 (4) ◽  
pp. 345-360
Author(s):  
Scott D. Rhodes ◽  
Lisa M. Kuhns ◽  
Jasmine Alexander ◽  
Jorge Alonzo ◽  
Patricia A. Bessler ◽  
...  
Keyword(s):  
United States ◽  
Hiv Risk ◽  
Ethnically Diverse ◽  
The United States ◽  
Transgender Women ◽  
Evidence Based ◽  
Key Population ◽  
Prevention Interventions ◽  
Control And Prevention ◽  
Exposure Prophylaxis

In the United States, transgender women are disproportionately affected by HIV. However, few evidence-based prevention interventions exist for this key population. We describe two promising, locally developed interventions that are currently being implemented and evaluated through the Centers for Disease Control and Prevention Combination HIV Prevention for Transgender Women Project: (a) ChiCAS, designed to promote the uptake of pre-exposure prophylaxis (PrEP), condom use, and medically supervised hormone therapy among Spanish-speaking transgender Latinas, and (b) TransLife Care, designed to address the structural drivers of HIV risk through access to housing, employment, legal services, and medical services, including HIV preventive care (e.g., PrEP use) among racially/ethnically diverse urban transgender women. If the evaluation trials determine that these interventions are effective, they will be among the first such interventions for use with transgender women incorporating PrEP, thereby contributing to the evidence-based resources that may be used to reduce HIV risk among this population.

Developing targeted HIV risk predictors for young black men who have sex with men: a two-city comparative study

2020 ◽  
Vol 31 (4) ◽  
pp. 335-344
Author(s):  
Anthony C Nguyen ◽  
Lindsay E Young ◽  
Matthew R Beymer ◽  
Sze-Chuan Suen
Keyword(s):  
United States ◽  
Los Angeles ◽  
Black Men ◽  
Hiv Risk ◽  
The United States ◽  
Risk Indicator ◽  
Screening Guidelines ◽  
Control And Prevention ◽  
Sex With Men ◽  
Exposure Prophylaxis

HIV burden in the United States is geographically and demographically heterogeneous. While efforts over the last few decades have reduced HIV incidence, young black men who have sex with men (YBMSM) account for a significant portion of new HIV diagnoses compared to any other race and age group. The Centers for Disease Control and Prevention has allocated funding to help reduce HIV in the YBMSM community; however, their recommended screening/treatment criteria do not emphasize demographic specificity. To better guide more applicable screening guidelines specifically for YBMSM, we examine demographic, behavioral, sexual network, and biological predictors of HIV status among YBMSM in two demographically distinct cities with high HIV burden in the United States: Chicago, IL and Los Angeles, CA. We perform multivariable logistic regressions to identify predictors of HIV in these populations. We found that having a history of syphilis was the only statistically significant predictor across both cities despite inclusion of other characteristics previously shown to be associated with HIV among YBMSM. Syphilis history could be a powerful HIV risk indicator for YBMSM and, therefore, should be integrated into clinical screening practices for critical biomedical prevention options like HIV pre-exposure prophylaxis.

Non-medical use of prescription drugs and HIV risk behaviour in transgender women in the Mid-Atlantic region of the United States

2015 ◽  
Vol 27 (9) ◽  
pp. 776-782 ◽  
Author(s):  
Eric G Benotsch ◽  
Rick S Zimmerman ◽  
Laurie Cathers ◽  
Juan Pierce ◽  
Shawn McNulty ◽  
...  
Keyword(s):  
United States ◽  
Hiv Risk ◽  
Prescription Drugs ◽  
Risk Behaviour ◽  
The United States ◽  
Transgender Women ◽  
Atlantic Region

Structural Stigma Affects Access to Pre- and Post-exposure Prophylaxis and HIV Risk among Men Who Have Sex with Men (MSM) in the United States

2014 ◽  
Vol 30 (S1) ◽  
pp. A22-A23 ◽  
Author(s):  
Catherine Oldenburg ◽  
Amaya Perez-Brumer ◽  
Mark Hatzenbuehler ◽  
Douglas Krakower ◽  
David Novak ◽  
...  
Keyword(s):  
United States ◽  
Hiv Risk ◽  
The United States ◽  
Post Exposure Prophylaxis ◽  
Post Exposure ◽  
Sex With Men ◽  
Exposure Prophylaxis

scholarly journals Analytic Validation of Immunohistochemistry Assays: New Benchmark Data From a Survey of 1085 Laboratories

2017 ◽  
Vol 141 (9) ◽  
pp. 1255-1261 ◽  
Author(s):  
Lauren N. Stuart ◽  
Keith E. Volmar ◽  
Jan A. Nowak ◽  
Lisa A. Fatheree ◽  
Rhona J. Souers ◽  
...  
Keyword(s):  
United States ◽  
Disease Control ◽  
Practice Guideline ◽  
The United States ◽  
Predictive Markers ◽  
Evidence Based ◽  
Laboratory Practice ◽  
Initial Validation ◽  
Benchmark Data ◽  
Control And Prevention

Context.— A cooperative agreement between the College of American Pathologists (CAP) and the United States Centers for Disease Control and Prevention was undertaken to measure laboratories' awareness and implementation of an evidence-based laboratory practice guideline (LPG) on immunohistochemical (IHC) validation practices published in 2014. Objective.— To establish new benchmark data on IHC laboratory practices. Design.— A 2015 survey on IHC assay validation practices was sent to laboratories subscribed to specific CAP proficiency testing programs and to additional nonsubscribing laboratories that perform IHC testing. Specific questions were designed to capture laboratory practices not addressed in a 2010 survey. Results.— The analysis was based on responses from 1085 laboratories that perform IHC staining. Ninety-six percent (809 of 844) always documented validation of IHC assays. Sixty percent (648 of 1078) had separate procedures for predictive and nonpredictive markers, 42.7% (220 of 515) had procedures for laboratory-developed tests, 50% (349 of 697) had procedures for testing cytologic specimens, and 46.2% (363 of 785) had procedures for testing decalcified specimens. Minimum case numbers were specified by 85.9% (720 of 838) of laboratories for nonpredictive markers and 76% (584 of 768) for predictive markers. Median concordance requirements were 95% for both types. For initial validation, 75.4% (538 of 714) of laboratories adopted the 20-case minimum for nonpredictive markers and 45.9% (266 of 579) adopted the 40-case minimum for predictive markers as outlined in the 2014 LPG. The most common method for validation was correlation with morphology and expected results. Laboratories also reported which assay changes necessitated revalidation and their minimum case requirements. Conclusions.— Benchmark data on current IHC validation practices and procedures may help laboratories understand the issues and influence further refinement of LPG recommendations.

scholarly journals Harnessing “Scale-Up and Spread” to Support Community Uptake of the HoMBReS por un Cambio Intervention for Spanish-Speaking Men: Implementation Science Lessons Learned by a CBPR Partnership

2020 ◽  
Vol 14 (4) ◽  
pp. 155798832093893 ◽  
Author(s):  
Scott D. Rhodes ◽  
Lilli Mann-Jackson ◽  
Jorge Alonzo ◽  
Jennifer Nall ◽  
Florence M. Simán ◽  
...  
Keyword(s):  
United States ◽  
Implementation Science ◽  
Sexual Risk ◽  
Scale Up ◽  
The United States ◽  
Evidence Based ◽  
Public Health Department ◽  
Community Based ◽  
Spanish Speaking ◽  
Prevention Interventions

Latinx men in the southern United States are affected disproportionately by HIV and other sexually transmitted infections (STIs). However, few evidence-based prevention interventions exist to promote health equity within this population. Developed by a well-established community-based participatory research partnership, the HoMBReS por un Cambio intervention decreases sexual risk among Spanish-speaking, predominately heterosexual Latinx men who are members of recreational soccer teams in the United States. Scale-up and spread, an implementation science framework, was used to study the implementation of this evidence-based community-level intervention within three community organizations that represent typical community-based providers of HIV and STI prevention interventions (i.e., an AIDS service organization, a Latinx-serving organization, and a county public health department). Archival and interview data were analyzed, and 24 themes emerged that mapped onto the 12 scale-up and spread constructs. Themes included the importance of strong and attentive leadership, problem-solving challenges early, an established relationship between innovation developers and implementers, organizational capacity able to effectively work with men, trust building, timelines and incremental deadlines, clear and simple guidance regarding all aspects of implementation, appreciating the context (e.g., immigration-related rhetoric, policies, and actions), recognizing men’s competing priorities, and delineated supervision responsibilities. Scale-up and spread was a useful framework to understand multisite implementation of a sexual risk reduction intervention for Spanish-speaking, predominately heterosexual Latinx men. Further research is needed to identify how constructs, like those within scale-up and spread, affect the process across the implementation continuum, given that the uptake and implementation of an innovation is a process, not an event.

440: Barriers to the Practice of Evidence Based Urology in the United States

2007 ◽  
Vol 177 (4S) ◽  
pp. 147-148
Author(s):  
Philipp Dahm ◽  
Hubert R. Kuebler ◽  
Susan F. Fesperman ◽  
Roger L. Sur ◽  
Charles D. Scales ◽  
...  
Keyword(s):  
United States ◽  
The United States ◽  
Evidence Based
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