scholarly journals Noise Trauma-Induced Behavioral Gap Detection Deficits Correlate with Reorganization of Excitatory and Inhibitory Local Circuits in the Inferior Colliculus and Are Prevented by Acoustic Enrichment

2017 ◽  
Vol 37 (26) ◽  
pp. 6314-6330 ◽  
Author(s):  
Joshua J. Sturm ◽  
Ying-Xin Zhang-Hooks ◽  
Hannah Roos ◽  
Tuan Nguyen ◽  
Karl Kandler
Keyword(s):  
Inferior Colliculus ◽  
Gap Detection ◽  
Noise Trauma ◽  
Local Circuits

scholarly journals Acute and Long-Term Effects of Noise Exposure on the Neuronal Spontaneous Activity in Cochlear Nucleus and Inferior Colliculus Brain Slices

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Moritz Gröschel ◽  
Jana Ryll ◽  
Romy Götze ◽  
Arne Ernst ◽  
Dietmar Basta
Keyword(s):  
Hearing Loss ◽  
Spontaneous Activity ◽  
Inferior Colliculus ◽  
Cochlear Nucleus ◽  
Noise Exposure ◽  
Brain Slices ◽  
Noise Induced Hearing Loss ◽  
Long Term Effects ◽  
Noise Trauma

Noise exposure leads to an immediate hearing loss and is followed by a long-lasting permanent threshold shift, accompanied by changes of cellular properties within the central auditory pathway. Electrophysiological recordings have demonstrated an upregulation of spontaneous neuronal activity. It is still discussed if the observed effects are related to changes of peripheral input or evoked within the central auditory system. The present study should describe the intrinsic temporal patterns of single-unit activity upon noise-induced hearing loss of the dorsal and ventral cochlear nucleus (DCN and VCN) and the inferior colliculus (IC) in adult mouse brain slices. Recordings showed a slight, but significant, elevation in spontaneous firing rates in DCN and VCN immediately after noise trauma, whereas no differences were found in IC. One week postexposure, neuronal responses remained unchanged compared to controls. At 14 days after noise trauma, intrinsic long-term hyperactivity in brain slices of the DCN and the IC was detected for the first time. Therefore, increase in spontaneous activity seems to develop within the period of two weeks, but not before day 7. The results give insight into the complex temporal neurophysiological alterations after noise trauma, leading to a better understanding of central mechanisms in noise-induced hearing loss.

scholarly journals Background Noise Improves Gap Detection in Tonically Inhibited Inferior Colliculus Neurons

2002 ◽  
Vol 87 (1) ◽  
pp. 240-249 ◽  
Author(s):  
Willard W. Wilson ◽  
Joseph P. Walton
Keyword(s):  
Inferior Colliculus ◽  
Background Noise ◽  
Feature Detection ◽  
Inbred Mouse ◽  
Inbred Mouse Strain ◽  
Neural Mechanism ◽  
Silent Interval ◽  
Inhibitory Input ◽  
Gap Detection ◽  
Order Of Magnitude

Single units in the inferior colliculus (IC) in the C57Bl/6 inbred mouse strain were tested for their temporal processing ability as measured by their minimum gap threshold (MGT), the shortest silent interval in an ongoing white-noise stimulus which a unit could encode. After ascertaining the MGT in quiet, units were re-tested in various levels of background noise. The focus of this report is on two types of tonically responding units found in the IC. Tonically inhibited (TI) units encoded gaps poorly in quiet and low levels of background noise as compared with tonically excited (TE) units. In quiet, the MGTs of TI units were about an order of magnitude longer than the MGTs typical of TE units. Paradoxically, gap encoding was improved in high levels of background noise for TI units. This result is unexpected from the traditional viewpoint that noise necessarily degrades signal processing and is inconsistent with psychophysical observations of diminished speech and gap detection processing in noisy environments. We believe the improved feature detection described here is produced by the adaptation of inhibitory input. Continuous background noise would diminish the inhibitory efficacy of the gap stimulus by increasing the latency to the onset of inhibition and decreasing its duration. This would allow more spontaneous activity to “bleed through” the silent gap, thus signaling its presence. Improved feature detection in background noise resulting from inhibitory adaptation would seem an efficient neural mechanism and one that might be generally useful in other signal detection tasks.

Neural correlates of behavioral gap detection in the inferior colliculus of the young CBA mouse

1997 ◽  
Vol 181 (2) ◽  
pp. 161-176 ◽  
Author(s):  
J. P. Walton ◽  
R. D. Frisina ◽  
J. R. Ison ◽  
W. E. O'Neill
Keyword(s):  
Inferior Colliculus ◽  
Neural Correlates ◽  
Gap Detection

Neuron Types, Intrinsic Circuits, and Plasticity in the Inferior Colliculus

2018 ◽  
pp. 502-526
Author(s):  
Tetsufumi Ito ◽  
Munenori Ono ◽  
Douglas L. Oliver
Keyword(s):  
Inferior Colliculus ◽  
De Novo ◽  
Future Research ◽  
Auditory Information ◽  
Wide Range ◽  
Neuronal Types ◽  
Key Issues ◽  
Complex Features ◽  
Local Circuits ◽  
Local Connection

The inferior colliculus is a critical auditory center in the midbrain which virtually acts as a hub of all ascending and descending auditory information flows. Wide variety of neuronal responses to sound is found in the IC, and this variety emerges not only from the wide range of extrinsic afferent inputs, but also from the complex features of the local circuits in the IC, for example, the mosaic pattern of extrinsic fiber termination, the various neuronal types each of which compose different patterns of local connection, and the unique forms of synaptic plasticity de novo. This chapter reviews the recent progress in understanding these features, and identifies the key issues for future research.

Author response for "Distribution and co‐expression of adrenergic receptor‐encoding mRNA in the mouse inferior colliculus"

2020 ◽  
Author(s):  
Charles A. Williams ◽  
Kimberly E. Miller ◽  
Nisa P. Williams ◽  
Christine V. Portfors ◽  
David J. Perkel
Keyword(s):  
Inferior Colliculus ◽  
Adrenergic Receptor ◽  
Author Response

Temporal-Gap Detection by Cochlear Prosthesis Users

1989 ◽  
Vol 32 (4) ◽  
pp. 849-856 ◽  
Author(s):  
John P. Preece ◽  
Richard S. Tyler
Keyword(s):  
Magnitude Estimation ◽  
Stimulus Level ◽  
Electrode Placement ◽  
Frequency Effect ◽  
Gap Detection ◽  
Cochlear Prosthesis ◽  
Sensation Level

Minimum-detectable gaps for sinusoidal stimuli were measured for three users of a multi electrode cochlear prosthesis as functions of stimulus level, frequency, and electrode place within the cochlea. Stimulus level was scaled by sensation level and by growth-of-loudness functions generated for each condition by direct magnitude estimation. Minimum-detectable gaps decreased with increase in either sensation level or loudness, up to a plateau. When compared at equal sensation levels, the minimum-detectable gaps decreased with frequency increases. The frequency effect on minimum-detectable gaps is reduced if the data are considered at equal loudness. Comparison across place of stimulation within the cochlea showed minimum-detectable gaps to be shorter for more basal electrode placement at low stimulus levels. No differences in minimum-detectable gap as a function of place were found at higher stimulus levels.

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