scholarly journals Suppression of Hyperpolarization-Activated Cyclic Nucleotide-Gated Channel Function in Thalamocortical Neurons Prevents Genetically Determined and Pharmacologically Induced Absence Seizures

2018 ◽  
Vol 38 (30) ◽  
pp. 6615-6627 ◽  
Author(s):  
François David ◽  
Nihan Çarçak ◽  
Szabina Furdan ◽  
Filiz Onat ◽  
Timothy Gould ◽  
...  
Keyword(s):  
Cyclic Nucleotide ◽  
Absence Seizures ◽  
Channel Function ◽  
Gated Channel ◽  
Genetically Determined

scholarly journals Systemic administration of ivabradine, a hyperpolarization‐activated cyclic nucleotide‐gated channel inhibitor, blocks spontaneous absence seizures

Epilepsia ◽  
2021 ◽  
Author(s):  
Yasmine Iacone ◽  
Tatiana P. Morais ◽  
François David ◽  
Francis Delicata ◽  
Joanna Sandle ◽  
...  
Keyword(s):  
Cyclic Nucleotide ◽  
Systemic Administration ◽  
Absence Seizures ◽  
Gated Channel

scholarly journals Development of a High-Throughput Ca2+ Flux Screening Assay to Monitor Cyclic Nucleotide-Gated Channel Activity and Evaluate Achromatopsia Disease Mutant Channel Function

2019 ◽  
Vol 116 (3) ◽  
pp. 107a-108a
Author(s):  
Jacqueline Tanaka ◽  
Cristy Almonte ◽  
Elizabeth McDuffie ◽  
Laura Jones ◽  
Dennis Colussi ◽  
...  
Keyword(s):  
High Throughput ◽  
Cyclic Nucleotide ◽  
Channel Activity ◽  
Screening Assay ◽  
Mutant Channel ◽  
Channel Function ◽  
Gated Channel

High-Throughput Ca2+ Flux Assay To Monitor Cyclic Nucleotide-Gated Channel Activity and Characterize Achromatopsia Mutant Channel Function

2019 ◽  
Vol 10 (8) ◽  
pp. 3662-3670
Author(s):  
Marlene A. Jacobson ◽  
Laura J. Jones ◽  
Dennis J. Colussi ◽  
Jacqueline C. Tanaka
Keyword(s):  
High Throughput ◽  
Cyclic Nucleotide ◽  
Channel Activity ◽  
Mutant Channel ◽  
Channel Function ◽  
Gated Channel

Impairment of Hyperpolarization-Activated, Cyclic Nucleotide-Gated Channel Function by the Intravenous General Anesthetic Propofol

2005 ◽  
Vol 315 (2) ◽  
pp. 517-525 ◽  
Author(s):  
Luisa P. Cacheaux ◽  
Norbert Topf ◽  
Gareth R. Tibbs ◽  
Ulrich R. Schaefer ◽  
Roberto Levi ◽  
...  
Keyword(s):  
Cyclic Nucleotide ◽  
General Anesthetic ◽  
Channel Function ◽  
Gated Channel

Expression of the olfactory cyclic nucleotide gated channel (CNG1) in the rat brain

Neuroreport ◽  
1995 ◽  
Vol 6 (10) ◽  
pp. 1459-1463 ◽  
Author(s):  
Alaa El-Din El-Husseini ◽  
Christopher Bladen ◽  
Steven R. Vincent
Keyword(s):  
Rat Brain ◽  
Cyclic Nucleotide ◽  
Gated Channel

Impaired Opsin Targeting and Cone Photoreceptor Migration in the Retina of Mice Lacking the Cyclic Nucleotide-Gated Channel CNGA3

2005 ◽  
Vol 46 (4) ◽  
pp. 1516 ◽  
Author(s):  
Stylianos Michalakis ◽  
Heidi Geiger ◽  
Silke Haverkamp ◽  
Franz Hofmann ◽  
Andrea Gerstner ◽  
...  
Keyword(s):  
Cyclic Nucleotide ◽  
Cone Photoreceptor ◽  
Gated Channel

Divalent cations block the cyclic nucleotide-gated channel of olfactory receptor neurons

1993 ◽  
Vol 69 (5) ◽  
pp. 1758-1768 ◽  
Author(s):  
F. Zufall ◽  
S. Firestein
Keyword(s):  
Cyclic Amp ◽  
Calcium Channels ◽  
Cyclic Nucleotide ◽  
Olfactory Receptor ◽  
Single Channel ◽  
Divalent Cations ◽  
Olfactory Receptor Neurons ◽  
Gated Channel ◽  
Receptor Neurons ◽  
Single Channel Currents

1. The effects of external divalent cations on odor-dependent, cyclic AMP-activated single-channel currents from olfactory receptor neurons of the tiger salamander (Ambystoma tigrinum) were studied in inside-out membrane patches taken from dendritic regions of freshly isolated sensory cells. 2. Channels were reversibly activated by 100 microM cyclic AMP. In the absence of divalent cations, the channel had a linear current-voltage relation giving a conductance of 45 pS. With increasing concentrations of either Ca2+ or Mg2+ in the external solution, the channel displayed a rapid flickering behavior. At higher concentrations of divalent cations, the transitions were too rapid to be fully resolved and appeared as a reduction in mean unitary single-channel current amplitude. 3. This effect was voltage dependent, and on analysis was shown to be due to an open channel block by divalent ions. In the case of Mg2+, the block increased steadily with hyperpolarization. In contrast, for Ca2+ the block first increased with hyperpolarization and then decreased with further hyperpolarization beyond -70 mV, providing evidence for Ca2+ permeation of this channel. 4. This block is similar to that seen in voltage-gated calcium channels. Additionally, the cyclic nucleotide-gated channel shows some pharmacological similarities with L-type calcium channels, including a novel block of the cyclic nucleotide channel by nifedipine (50 microM). 5. Our results indicate that the sensory generator current simultaneously depends on the presence of the second messenger and on the membrane potential of the olfactory neuron.

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