scholarly journals Interleukin-1 induces substance P in sympathetic ganglia through the induction of leukemia inhibitory factor (LIF)

1993 ◽  
Vol 13 (6) ◽  
pp. 2601-2609 ◽  
Author(s):  
AM Shadiack ◽  
RP Hart ◽  
CD Carlson ◽  
GM Jonakait
1996 ◽  
Vol 70 (2) ◽  
pp. 181-190 ◽  
Author(s):  
Christopher D. Carlson ◽  
Yuchen Bai ◽  
Minzhen Ding ◽  
G. Miller Jonakait ◽  
Ronald P. Hart

1992 ◽  
Vol 175 (4) ◽  
pp. 1139-1142 ◽  
Author(s):  
H R Alexander ◽  
G G Wong ◽  
G M Doherty ◽  
D J Venzon ◽  
D L Fraker ◽  
...  

Differentiation factor (D factor), also called leukemia inhibitory factor (LIF), is a glycoprotein that has been increasingly recognized to possess a wide range of physiological activities. We examined the possibility that the administration of D factor may confer beneficial effects and enhance host resistance against lethal endotoxemia. A single intravenous dose of recombinant human D factor completely protected C57/Bl6 mice from the lethal effect of Escherichia coli endotoxin (lipopolysaccharide [LPS]). The protective effects were dose dependent and observed when administered 2-24 h before LPS. Previous work has shown that interleukin 1 (IL-1) and tumor necrosis factor (TNF) also protect against a subsequent LPS challenge in a dose-dependent manner. When human D factor was combined with sub-protective doses of IL-1 beta or TNF-alpha, there was dramatic synergistic protection against a subsequent lethal LPS challenge.


1999 ◽  
Vol 19 (2) ◽  
pp. 197-208 ◽  
Author(s):  
M.C. Bell ◽  
G.J. Carroll ◽  
H.M. Chapman ◽  
J.N. Mills ◽  
M.J. Layton ◽  
...  

2008 ◽  
Vol 79 (1) ◽  
pp. 142-153 ◽  
Author(s):  
A.A. Fouladi-Nashta ◽  
L. Mohamet ◽  
J.K. Heath ◽  
S.J. Kimber

Endocrinology ◽  
2004 ◽  
Vol 145 (8) ◽  
pp. 3850-3857 ◽  
Author(s):  
R. R. Gonzalez ◽  
B. R. Rueda ◽  
M. P. Ramos ◽  
R. D. Littell ◽  
S. Glasser ◽  
...  

1991 ◽  
Vol 29 (3) ◽  
pp. 282-291 ◽  
Author(s):  
R. P. Hart ◽  
A. M. Shadiack ◽  
G. M. Jonakait

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