scholarly journals Concomitant Deficits in Working Memory and Fear Extinction Are Functionally Dissociated from Reduced Anxiety in Metabotropic Glutamate Receptor 7-Deficient Mice

2006 ◽  
Vol 26 (24) ◽  
pp. 6573-6582 ◽  
Author(s):  
Z. Callaerts-Vegh ◽  
T. Beckers ◽  
S. M. Ball ◽  
F. Baeyens ◽  
P. F. Callaerts ◽  
...  
Keyword(s):  
Working Memory ◽  
Glutamate Receptor ◽  
Metabotropic Glutamate Receptor ◽  
Fear Extinction ◽  
Metabotropic Glutamate ◽  
Deficient Mice

Blockade of amygdala metabotropic glutamate receptor subtype 1 impairs fear extinction

2007 ◽  
Vol 355 (1) ◽  
pp. 188-193 ◽  
Author(s):  
Jeongyeon Kim ◽  
Sukwon Lee ◽  
Heewoo Park ◽  
Beomjong Song ◽  
Ingie Hong ◽  
...  
Keyword(s):  
Glutamate Receptor ◽  
Metabotropic Glutamate Receptor ◽  
Fear Extinction ◽  
Receptor Subtype ◽  
Metabotropic Glutamate

scholarly journals Metabotropic glutamate receptor 3 activation is required for long-term depression in medial prefrontal cortex and fear extinction

2015 ◽  
Vol 112 (4) ◽  
pp. 1196-1201 ◽  
Author(s):  
Adam G. Walker ◽  
Cody J. Wenthur ◽  
Zixiu Xiang ◽  
Jerri M. Rook ◽  
Kyle A. Emmitte ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Glutamate Receptor ◽  
Metabotropic Glutamate Receptor ◽  
Fear Extinction ◽  
Long Term Depression ◽  
Metabotropic Glutamate ◽  
Metabotropic Glutamate Receptor 3

Clinical studies have revealed that genetic variations in metabotropic glutamate receptor 3 (mGlu3) affect performance on cognitive tasks dependent upon the prefrontal cortex (PFC) and may be linked to psychiatric conditions such as schizophrenia, bipolar disorder, and addiction. We have performed a series of studies aimed at understanding how mGlu3 influences PFC function and cognitive behaviors. In the present study, we found that activation of mGlu3 can induce long-term depression in the mouse medial PFC (mPFC) in vitro. Furthermore, in vivo administration of a selective mGlu3 negative allosteric modulator impaired learning in the mPFC-dependent fear extinction task. The results of these studies implicate mGlu3 as a major regulator of PFC function and cognition. Additionally, potentiators of mGlu3 may be useful in alleviating prefrontal impairments associated with several CNS disorders.

Lack of the metabotropic glutamate receptor subtype 7 selectively impairs short-term working memory but not long-term memory

2004 ◽  
Vol 154 (2) ◽  
pp. 473-481 ◽  
Author(s):  
Christian Hölscher ◽  
Susanne Schmid ◽  
Peter K.D. Pilz ◽  
Gilles Sansig ◽  
Herman van der Putten ◽  
...  
Keyword(s):  
Working Memory ◽  
Glutamate Receptor ◽  
Metabotropic Glutamate Receptor ◽  
Long Term Memory ◽  
Receptor Subtype ◽  
Short Term ◽  
Term Memory ◽  
Metabotropic Glutamate

Impaired behavioral suppression by light in metabotropic glutamate receptor subtype 6-deficient mice

Neuroscience ◽  
2000 ◽  
Vol 97 (4) ◽  
pp. 779-787 ◽  
Author(s):  
M Takao ◽  
K Morigiwa ◽  
H Sasaki ◽  
T Miyoshi ◽  
T Shima ◽  
...  
Keyword(s):  
Glutamate Receptor ◽  
Metabotropic Glutamate Receptor ◽  
Receptor Subtype ◽  
Metabotropic Glutamate ◽  
Behavioral Suppression ◽  
Deficient Mice
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