scholarly journals Patterns of Neural Circuit Activation and Behavior during Dominance Hierarchy Formation in Freely Behaving Crayfish

2001 ◽  
Vol 21 (8) ◽  
pp. 2759-2767 ◽  
Author(s):  
Jens Herberholz ◽  
Fadi A. Issa ◽  
Donald H. Edwards
Keyword(s):  
Dominance Hierarchy ◽  
Neural Circuit ◽  
Hierarchy Formation ◽  
Freely Behaving ◽  
And Behavior

scholarly journals An Intracortical Implantable Brain-Computer Interface for Telemetric Real-Time Recording and Manipulation of Neuronal Circuits for Closed-Loop Intervention

2021 ◽  
Vol 15 ◽  
Author(s):  
Hamed Zaer ◽  
Ashlesha Deshmukh ◽  
Dariusz Orlowski ◽  
Wei Fan ◽  
Pierre-Hugues Prouvot ◽  
...  
Keyword(s):  
Visual Cortex ◽  
Real Time ◽  
Neuronal Activity ◽  
Closed Loop ◽  
Neural Circuit ◽  
Radio Communication ◽  
Computer Interfaces ◽  
Cerebral Mri ◽  
High Bandwidth ◽  
And Behavior

Recording and manipulating neuronal ensemble activity is a key requirement in advanced neuromodulatory and behavior studies. Devices capable of both recording and manipulating neuronal activity brain-computer interfaces (BCIs) should ideally operate un-tethered and allow chronic longitudinal manipulations in the freely moving animal. In this study, we designed a new intracortical BCI feasible of telemetric recording and stimulating local gray and white matter of visual neural circuit after irradiation exposure. To increase the translational reliance, we put forward a Göttingen minipig model. The animal was stereotactically irradiated at the level of the visual cortex upon defining the target by a fused cerebral MRI and CT scan. A fully implantable neural telemetry system consisting of a 64 channel intracortical multielectrode array, a telemetry capsule, and an inductive rechargeable battery was then implanted into the visual cortex to record and manipulate local field potentials, and multi-unit activity. We achieved a 3-month stability of the functionality of the un-tethered BCI in terms of telemetric radio-communication, inductive battery charging, and device biocompatibility for 3 months. Finally, we could reliably record the local signature of sub- and suprathreshold neuronal activity in the visual cortex with high bandwidth without complications. The ability to wireless induction charging combined with the entirely implantable design, the rather high recording bandwidth, and the ability to record and stimulate simultaneously put forward a wireless BCI capable of long-term un-tethered real-time communication for causal preclinical circuit-based closed-loop interventions.

scholarly journals Perceptual detection depends on spike count integration

2019 ◽  
Author(s):  
Jackson J. Cone ◽  
Morgan L. Bade ◽  
Nicolas Y. Masse ◽  
Elizabeth A. Page ◽  
David J. Freedman ◽  
...  
Keyword(s):  
Neural Networks ◽  
Cerebral Cortex ◽  
Visual Cortex ◽  
Recurrent Neural Networks ◽  
Neural Circuit ◽  
Visual Detection ◽  
Spike Count ◽  
Neuronal Responses ◽  
Neuronal Populations ◽  
And Behavior

AbstractWhenever the retinal image changes some neurons in visual cortex increase their rate of firing, while others decrease their rate of firing. Linking specific sets of neuronal responses with perception and behavior is essential for understanding mechanisms of neural circuit computation. We trained mice to perform visual detection tasks and used optogenetic perturbations to increase or decrease neuronal spiking primary visual cortex (V1). Perceptual reports were always enhanced by increments in V1 spike counts and impaired by decrements, even when increments and decrements were delivered to the same neuronal populations. Moreover, detecting changes in cortical activity depended on spike count integration rather than instantaneous changes in spiking. Recurrent neural networks trained in the task similarly relied on increments in neuronal activity when activity was costly. This work clarifies neuronal decoding strategies employed by cerebral cortex to translate cortical spiking into percepts that can be used to guide behavior.

The establishment and maintenance of dominance hierarchies

2022 ◽  
Vol 377 (1845) ◽  
Author(s):  
Elizabeth A. Tibbetts ◽  
Juanita Pardo-Sanchez ◽  
Chloe Weise
Keyword(s):  
Dominance Hierarchy ◽  
Social Dynamics ◽  
Dominance Rank ◽  
Future Research ◽  
Dominance Hierarchies ◽  
Dominance Relationships ◽  
Hierarchy Formation ◽  
Behavioural Dynamics ◽  
Self Organizing

Animal groups are often organized hierarchically, with dominant individuals gaining priority access to resources and reproduction over subordinate individuals. Initial dominance hierarchy formation may be influenced by multiple interacting factors, including an animal's individual attributes, conventions and self-organizing social dynamics. After establishment, hierarchies are typically maintained over the long-term because individuals save time, energy and reduce the risk of injury by recognizing and abiding by established dominance relationships. A separate set of behaviours are used to maintain dominance relationships within groups, including behaviours that stabilize ranks (punishment, threats, behavioural asymmetry), as well as signals that provide information about dominance rank (individual identity signals, signals of dominance). In this review, we describe the behaviours used to establish and maintain dominance hierarchies across different taxa and types of societies. We also review opportunities for future research including: testing how self-organizing behavioural dynamics interact with other factors to mediate dominance hierarchy formation, measuring the long-term stability of social hierarchies and the factors that disrupt hierarchy stability, incorporating phenotypic plasticity into our understanding of the behavioural dynamics of hierarchies and considering how cognition coevolves with the behaviours used to establish and maintain hierarchies. This article is part of the theme issue ‘The centennial of the pecking order: current state and future prospects for the study of dominance hierarchies’.

Charney & Nestler's Neurobiology of Mental Illness

2017 ◽  
Keyword(s):  
Mental Illness ◽  
Cell Biology ◽  
Neural Circuit ◽  
Disease Etiology ◽  
Complex Genetics ◽  
Dsm 5 ◽  
Technical Advances ◽  
Section Viii ◽  
New Treatments ◽  
And Behavior

In the years following publication of the DSM-5, the field of psychiatry has seen vigorous debate between the DSM’s more traditional, diagnosis-oriented approach and the NIMH’s more biological, dimension-based RDoC approach. Charney & Nestler’s Neurobiology of Mental Illness is an authoritative foundation for translating information from the laboratory to clinical treatment, and this edition extends beyond its reference function to acknowledge and examine the controversies and thoughts on the future of psychiatric diagnosis. In this wider context, this book provides information from numerous levels of analysis including molecular biology and genetics, cellular physiology, neuroanatomy, neuropharmacology, epidemiology, and behavior. Section I, which reviews the methods used to examine the biological basis of mental illness in animal and cell models and in humans, has been expanded to reflect important technical advances in complex genetics, epigenetics, stem cell biology, optogenetics, neural circuit functioning, cognitive neuroscience, and brain imaging. These established and emerging methodologies offer groundbreaking advances in our ability to study the brain and breakthroughs in our therapeutic toolkit. Sections II through VII cover the neurobiology and genetics of major psychiatric disorders: psychoses, mood disorders, anxiety disorders, substance use disorders, dementias, and disorders of childhood onset. Also covered within these sections is a summary of current therapeutic approaches for these illnesses as well as the ways in which research advances are now guiding the search for new treatments. The last section, Section VIII, focuses on diagnostic schemes for mental illness. This includes an overview of the unique challenges that remain in diagnosing these disorders given our still limited knowledge of disease etiology and pathophysiology. The section then provides reviews of DSM-5 and RDoC. Also included are chapters on future efforts toward precision and computational psychiatry, which promise to someday align diagnosis with underlying biological abnormalities.

Ecology and behavior of the Cretan agrimi

1984 ◽  
Vol 62 (3) ◽  
pp. 411-420 ◽  
Author(s):  
Thomas P. Husband ◽  
Phillip B. Davis
Keyword(s):  
Social Dominance ◽  
Dominance Hierarchy ◽  
Activity Patterns ◽  
Natural Mortality ◽  
Ambient Temperatures ◽  
Population Responses ◽  
Capra Aegagrus ◽  
Population Mortality ◽  
And Behavior ◽  
Daily Activity Patterns

The agrimi (Capra aegagrus cretensis Lydekker), an endangered species of wild goat, was studied on Theodorou Island, Crete, Greece, from May to November 1975 to determine population responses of the agrimi to removals and to document their behavioral patterns. The Theodorou population size was 89 agrimi. A mathematical model of population mortality indicated that the number of animals removed from the island between 1973 and 1975 equalled the expected natural mortality for both sexes. Observations of agrimi showed that they had seasonal and daily activity patterns that minimized their exposure to high ambient temperatures. An age- and sex-specific social dominance hierarchy was found, with old males being most dominant.

scholarly journals Wireless Neural Stimulation in Freely Behaving Small Animals

2009 ◽  
Vol 102 (1) ◽  
pp. 598-605 ◽  
Author(s):  
Scott K. Arfin ◽  
Michael A. Long ◽  
Michale S. Fee ◽  
Rahul Sarpeshkar
Keyword(s):  
Neural Circuit ◽  
Neural Stimulation ◽  
Strong Increase ◽  
Battery Life ◽  
Sleep Mode ◽  
Motor Nucleus ◽  
Wireless Receiver ◽  
Bipolar Electrodes ◽  
Downstream Target ◽  
Freely Behaving

We introduce a novel wireless, low-power neural stimulation system for use in freely behaving animals. The system consists of an external transmitter and a miniature, implantable wireless receiver–stimulator. The implant uses a custom integrated chip to deliver biphasic current pulses to four addressable bipolar electrodes at 32 selectable current levels (10 μA to 1 mA). To achieve maximal battery life, the chip enters a sleep mode when not needed and can be awakened remotely when required. To test our device, we implanted bipolar stimulating electrodes into the songbird motor nucleus HVC (formerly called the high vocal center) of zebra finches. Single-neuron recordings revealed that wireless stimulation of HVC led to a strong increase of spiking activity in its downstream target, the robust nucleus of the arcopallium. When we used this device to deliver biphasic pulses of current randomly during singing, singing activity was prematurely terminated in all birds tested. Thus our device is highly effective for remotely modulating a neural circuit and its corresponding behavior in an untethered, freely behaving animal.

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