scholarly journals Appetitive Instrumental Learning Requires Coincident Activation of NMDA and Dopamine D1 Receptors within the Medial Prefrontal Cortex

2002 ◽  
Vol 22 (3) ◽  
pp. 1063-1071 ◽  
Author(s):  
Anne E. Baldwin ◽  
Kenneth Sadeghian ◽  
Ann E. Kelley
Keyword(s):  
Prefrontal Cortex ◽  
Medial Prefrontal Cortex ◽  
Instrumental Learning ◽  
D1 Receptors ◽  
Dopamine D1 Receptors

scholarly journals Activation of Dopamine D1 Receptors Regulates Dendritic Morphogenesis Through Rac1 and RhoA in Prefrontal Cortex Neurons

2014 ◽  
Vol 51 (3) ◽  
pp. 1024-1037 ◽  
Author(s):  
Juan Li ◽  
Jingjing Gu ◽  
Bin Wang ◽  
Minjuan Xie ◽  
Lu Huang ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
D1 Receptors ◽  
Dopamine D1 Receptors ◽  
Dendritic Morphogenesis

scholarly journals Dopamine modulates adaptive forgetting in medial prefrontal cortex

2021 ◽  
Author(s):  
Francisco Tomas Gallo ◽  
Maria Belen Zanoni-Saad ◽  
Juan Facundo Morici ◽  
Magdalena Miranda ◽  
Michael C Anderson ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Medial Prefrontal Cortex ◽  
Familiar Object ◽  
D1 Receptors ◽  
Long Term Memory ◽  
Dopamine Signaling ◽  
Induced Forgetting ◽  
Adaptive Forgetting

Active forgetting occurs in many species, but how the mechanisms that control behavior contribute to determining which memories are forgotten is still unknown. We previously found that when rats need to retrieve particular memories to guide exploration, it reduces later retention of other memories encoded in that environment. As with humans, this retrieval-induced forgetting relies on prefrontal control processes. The dopaminergic input to the prefrontal cortex is important for executive functions and cognitive flexibility. We found that, in a similar way, prefrontal dopamine signaling through D1 receptors is required for retrieval-induced forgetting in rats. Blockade of medial prefrontal cortex D1 receptors as animals encountered a familiar object impaired forgetting of the memory of a competing object in a subsequent long-term memory test. Inactivation of the ventral tegmental area produced the same pattern of behavior, a pattern that could be reversed by concomitant activation of prefrontal D1 receptors. We observed a bidirectional modulation of retrieval-induced forgetting by agonists and antagonists of D1 receptors in the medial prefrontal cortex. These findings establish the essential role of prefrontal dopamine in the active forgetting of competing memories, contributing to the shaping of retention in response to an organism behavioral goals.

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