scholarly journals Glutamate Receptor Subunit 2 Serine 880 Phosphorylation Modulates Synaptic Transmission and Mediates Plasticity in CA1 Pyramidal Cells

2003 ◽  
Vol 23 (27) ◽  
pp. 9220-9228 ◽  
Author(s):  
Kenneth J. Seidenman ◽  
Jordan P. Steinberg ◽  
Richard Huganir ◽  
Roberto Malinow
Keyword(s):  
Synaptic Transmission ◽  
Glutamate Receptor ◽  
Pyramidal Cells ◽  
Receptor Subunit ◽  
Ca1 Pyramidal Cells ◽  
Glutamate Receptor Subunit

scholarly journals Regulation of glutamate receptor subunit availability by microRNAs

2009 ◽  
Vol 185 (4) ◽  
pp. 685-697 ◽  
Author(s):  
Julie Karr ◽  
Vasia Vagin ◽  
Kaiyun Chen ◽  
Subhashree Ganesan ◽  
Oxana Olenkina ◽  
...  
Keyword(s):  
Synaptic Transmission ◽  
Glutamate Receptors ◽  
Glutamate Receptor ◽  
Binding Sites ◽  
Messenger Rna ◽  
Molecular Mechanisms ◽  
Neuromuscular Junctions ◽  
Synaptic Strength ◽  
Receptor Subunit ◽  
Glutamate Receptor Subunit

The efficacy of synaptic transmission depends, to a large extent, on postsynaptic receptor abundance. The molecular mechanisms controlling receptor abundance are poorly understood. We tested whether abundance of postsynaptic glutamate receptors (GluRs) in Drosophila neuromuscular junctions is controlled by microRNAs, and provide evidence that it is. We show here that postsynaptic knockdown of dicer-1, the endoribonuclease necessary for microRNA synthesis, leads to large increases in postsynaptic GluR subunit messenger RNA and protein. Specifically, we measured increases in GluRIIA and GluRIIB but not GluRIIC. Further, knockout of MiR-284, a microRNA predicted to bind to GluRIIA and GluRIIB but not GluRIIC, increases expression of GluRIIA and GluRIIB but not GluRIIC proportional to the number of predicted binding sites in each transcript. Most of the de-repressed GluR protein, however, does not appear to be incorporated into functional receptors, and only minor changes in synaptic strength are observed, which suggests that microRNAs primarily regulate Drosophila receptor subunit composition rather than overall receptor abundance or synaptic strength.

Molecular and electrophysiological characterizations of fGluR3α, an ionotropic glutamate receptor subunit of a teleost fish

1998 ◽  
Vol 57 (2) ◽  
pp. 211-220 ◽  
Author(s):  
Hsiu-Ming Chang ◽  
Yi-Mi Wu ◽  
Yen-Chung Chang ◽  
Yu-Chung Hsu ◽  
Hsiu-Ya Hsu ◽  
...  
Keyword(s):  
Glutamate Receptor ◽  
Teleost Fish ◽  
Ionotropic Glutamate Receptor ◽  
Receptor Subunit ◽  
Glutamate Receptor Subunit

scholarly journals Transmembrane topology of the glutamate receptor subunit GluR6.

1994 ◽  
Vol 269 (16) ◽  
pp. 11679-11682
Author(s):  
K.W. Roche ◽  
L.A. Raymond ◽  
C. Blackstone ◽  
R.L. Huganir
Keyword(s):  
Glutamate Receptor ◽  
Receptor Subunit ◽  
Transmembrane Topology ◽  
Glutamate Receptor Subunit

Localization of the glutamate receptor subunit GluR1 on the surface of living and within cultured hippocampal neurons

Neuroscience ◽  
1996 ◽  
Vol 75 (1) ◽  
pp. 69-82 ◽  
Author(s):  
S.A Richmond ◽  
A.J Irving ◽  
E Molnár ◽  
R.A.J McIlhinney ◽  
F Michelangeli ◽  
...  
Keyword(s):  
Glutamate Receptor ◽  
Hippocampal Neurons ◽  
Receptor Subunit ◽  
Glutamate Receptor Subunit ◽  
Cultured Hippocampal Neurons
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