scholarly journals Conditional Muller Cell Ablation Causes Independent Neuronal and Vascular Pathologies in a Novel Transgenic Model

2012 ◽  
Vol 32 (45) ◽  
pp. 15715-15727 ◽  
Author(s):  
W. Shen ◽  
M. Fruttiger ◽  
L. Zhu ◽  
S. H. Chung ◽  
N. L. Barnett ◽  
...  
Keyword(s):  
Müller Cell ◽  
Transgenic Model ◽  
Cell Ablation ◽  
Muller Cell

Differential Gene Expression Profiling after Conditional Müller-Cell Ablation in a Novel Transgenic Model

2013 ◽  
Vol 54 (3) ◽  
pp. 2142 ◽  
Author(s):  
Sook Hyun Chung ◽  
Weiyong Shen ◽  
Kaushala Jayawardana ◽  
Penghao Wang ◽  
Jean Yang ◽  
...  
Keyword(s):  
Gene Expression ◽  
Gene Expression Profiling ◽  
Differential Gene Expression ◽  
Expression Profiling ◽  
Müller Cell ◽  
Transgenic Model ◽  
Cell Ablation ◽  
Differential Gene ◽  
Muller Cell

Effect of glucocorticoids on neuronal and vascular pathology in a transgenic model of selective Müller cell ablation

Glia ◽  
2014 ◽  
Vol 62 (7) ◽  
pp. 1110-1124 ◽  
Author(s):  
Weiyong Shen ◽  
So-Ra Lee ◽  
Joana Araujo ◽  
Sook H. Chung ◽  
Ling Zhu ◽  
...  
Keyword(s):  
Müller Cell ◽  
Vascular Pathology ◽  
Transgenic Model ◽  
Cell Ablation ◽  
Muller Cell

scholarly journals Involvement of NT3 and P75NTR in photoreceptor degeneration following selective Müller cell ablation

2013 ◽  
Vol 10 (1) ◽  
pp. 137 ◽  
Author(s):  
Weiyong Shen ◽  
Ling Zhu ◽  
So-Ra Lee ◽  
Sook H Chung ◽  
Mark C Gillies
Keyword(s):  
Müller Cell ◽  
Photoreceptor Degeneration ◽  
Cell Ablation ◽  
Muller Cell

scholarly journals Conditional Müller Cell Ablation Leads to Retinal Iron Accumulation

2017 ◽  
Vol 58 (10) ◽  
pp. 4223 ◽  
Author(s):  
Bailey Baumann ◽  
Jacob Sterling ◽  
Ying Song ◽  
Delu Song ◽  
Marcus Fruttiger ◽  
...  
Keyword(s):  
Müller Cell ◽  
Iron Accumulation ◽  
Cell Ablation ◽  
Muller Cell

scholarly journals Profiling of MicroRNAs Involved in Retinal Degeneration Caused by Selective Müller Cell Ablation

PLoS ONE ◽  
2015 ◽  
Vol 10 (3) ◽  
pp. e0118949 ◽  
Author(s):  
Sook Hyun Chung ◽  
Mark Gillies ◽  
Yuki Sugiyama ◽  
Ling Zhu ◽  
So-Ra Lee ◽  
...  
Keyword(s):  
Retinal Degeneration ◽  
Müller Cell ◽  
Cell Ablation ◽  
Muller Cell

Demonstration of Retinal Glycogen with Silver Methenamine

1971 ◽  
Vol 29 ◽  
pp. 564-565
Author(s):  
A. W. Sedar ◽  
G. H. Bresnick
Keyword(s):  
Lactic Acid ◽  
Chromic Acid ◽  
Periodic Acid ◽  
Müller Cell ◽  
External Limiting Membrane ◽  
Electron Microscope Level ◽  
Reactive Process ◽  
Inner Limiting Membrane ◽  
Muller Cell ◽  
And Migration

After experimetnal damage to the retina with a variety of procedures Müller cell hypertrophy and migration occurs. According to Kuwabara and others the reactive process in these injuries is evidenced by a marked increase in amount of glycogen in the Müller cells. These cells were considered originally supporting elements with fiber processes extending throughout the retina from inner limiting membrane to external limiting membrane, but are known now to have high lactic acid dehydrogenase activity and the ability to synthesize glycogen. Since the periodic acid-chromic acid-silver methenamine technique was shown to demonstrate glycogen at the electron microscope level, it was selected to react with glycogen in the fine processes of the Müller cell that ramify among the neural elements in various layers of the retina and demarcate these cells cytologically. The Rhesus monkey was chosen as an example of a well vascularized retina and the rabbit as an example of a avascular retina to explore the possibilities of the technique.

scholarly journals VEGF Mediates Retinal Müller Cell Viability and Neuroprotection through BDNF in Diabetes

Biomolecules ◽  
2021 ◽  
Vol 11 (5) ◽  
pp. 712
Author(s):  
Yun-Zheng Le ◽  
Bei Xu ◽  
Ana J. Chucair-Elliott ◽  
Huiru Zhang ◽  
Meili Zhu
Keyword(s):  
Specific Protein ◽  
Müller Cell ◽  
Dependent Manner ◽  
Vascular Abnormalities ◽  
Extracellular Signal ◽  
Muller Cell ◽  
Protein Kinase Akt ◽  
Sirna Knockdown ◽  
Endothelial Growth Factor ◽  
Dose Dependent

To investigate the mechanism of vascular endothelial growth factor (VEGF) and brain-derived neurotrophic factor (BDNF) in Müller cell (MC) viability and neuroprotection in diabetic retinopathy (DR), we examined the role of VEGF in MC viability and BDNF production, and the effect of BDNF on MC viability under diabetic conditions. Mouse primary MCs and cells of a rat MC line, rMC1, were used in investigating MC viability and BDNF production under diabetic conditions. VEGF-stimulated BDNF production was confirmed in mice. The mechanism of BDNF-mediated MC viability was examined using siRNA knockdown. Under diabetic conditions, recombinant VEGF (rVEGF) stimulated MC viability and BDNF production in a dose-dependent manner. rBDNF also supported MC viability in a dose-dependent manner. Targeting BDNF receptor tropomyosin receptor kinase B (TRK-B) with siRNA knockdown substantially downregulated the activated (phosphorylated) form of serine/threonine-specific protein kinase (AKT) and extracellular signal-regulated kinase (ERK), classical survival and proliferation mediators. Finally, the loss of MC viability in TrkB siRNA transfected cells under diabetic conditions was rescued by rBDNF. Our results provide direct evidence that VEGF is a positive regulator for BDNF production in diabetes for the first time. This information is essential for developing BDNF-mediated neuroprotection in DR and hypoxic retinal diseases, and for improving anti-VEGF treatment for these blood–retina barrier disorders, in which VEGF is a major therapeutic target for vascular abnormalities.

Temporary impairment of Müller cell metabolism in the rat retina by intravitreal injection of fluorocitrate

1991 ◽  
Vol 53 (1) ◽  
pp. 115-122 ◽  
Author(s):  
M. Virgili ◽  
R. Paulsen ◽  
L. Villani ◽  
A. Contestabile ◽  
F. Fonnum
Keyword(s):  
Intravitreal Injection ◽  
Cell Metabolism ◽  
Müller Cell ◽  
Rat Retina ◽  
Muller Cell
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