scholarly journals Bicuculline-Sensitive Primary Afferent Depolarization Remains after Greatly Restricting Synaptic Transmission in the Mammalian Spinal Cord

2010 ◽  
Vol 30 (15) ◽  
pp. 5283-5288 ◽  
Author(s):  
J. Shreckengost ◽  
J. Calvo ◽  
J. Quevedo ◽  
S. Hochman
Keyword(s):  
Spinal Cord ◽  
Synaptic Transmission ◽  
Primary Afferent Depolarization ◽  
Primary Afferent

Primary afferent depolarization in frog spinal cord is associated with an increase in membrane conductance

1983 ◽  
Vol 61 (6) ◽  
pp. 626-631 ◽  
Author(s):  
Ante L. Padjen ◽  
Toshio Hashiguchi
Keyword(s):  
Spinal Cord ◽  
Linear Part ◽  
Membrane Conductance ◽  
Potassium Sulfate ◽  
Equilibrium Potential ◽  
Primary Afferent Depolarization ◽  
Primary Afferent ◽  
Frog Spinal Cord ◽  
Voltage Dependent ◽  
Afferent Terminals

The mechanism of primary afferent depolarization (PAD) was studied in the isolated frog spinal cord using intrafibre recording (microelectrodes filled with 0.6 M potassium sulfate) from large myelinated axons of dorsal roots. Standard current–clamp technique was used to obtain voltage–current (V–I) relationship. It was found that: (i) PAD is voltage dependent: its amplitude and rate of rise are increased with hyperpolarization; (ii) the slope of the linear part of the V–I curve obtained during PAD is decreased compared with the V–I curve at rest; (iii) the PAD equilibrium potential, estimated by extrapolation, ranged from −66 to −40 mV. These results suggest that PAD is associated with an increase in conductance of primary afferent terminals and thus seem to provide the first experimental evidence for the hypothesis that shunting of primary afferent membrane is the mechanism of presynaptic inhibition in the vertebrate nervous system.

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