scholarly journals Striatal Dysfunctions Associated with Mitochondrial DNA Damage in Dopaminergic Neurons in a Mouse Model of Parkinson's Disease

2011 ◽  
Vol 31 (48) ◽  
pp. 17649-17658 ◽  
Author(s):  
A. M. Pickrell ◽  
M. Pinto ◽  
A. Hida ◽  
C. T. Moraes
Keyword(s):  
Parkinson’S Disease ◽  
Dna Damage ◽  
Parkinson's Disease ◽  
Mitochondrial Dna ◽  
Mouse Model ◽  
Dopaminergic Neurons ◽  
Mitochondrial Dna Damage

scholarly journals Mitochondrial DNA damage: Molecular marker of vulnerable nigral neurons in Parkinson's disease

2014 ◽  
Vol 70 ◽  
pp. 214-223 ◽  
Author(s):  
Laurie H. Sanders ◽  
Jennifer McCoy ◽  
Xiaoping Hu ◽  
Pier G. Mastroberardino ◽  
Bryan C. Dickinson ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Dna Damage ◽  
Parkinson's Disease ◽  
Mitochondrial Dna ◽  
Molecular Marker ◽  
Mitochondrial Dna Damage

scholarly journals LRRK2 G2019S-induced mitochondrial DNA damage is LRRK2 kinase dependent and inhibition restores mtDNA integrity in Parkinson’s disease

2017 ◽  
Vol 26 (22) ◽  
pp. 4340-4351 ◽  
Author(s):  
Evan H Howlett ◽  
Nicholas Jensen ◽  
Frances Belmonte ◽  
Faria Zafar ◽  
Xiaoping Hu ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Dna Damage ◽  
Parkinson's Disease ◽  
Mitochondrial Dna ◽  
Mitochondrial Dna Damage ◽  
Lrrk2 G2019s ◽  
Lrrk2 Kinase

scholarly journals LRRK2 mutations cause mitochondrial DNA damage in iPSC-derived neural cells from Parkinson's disease patients: Reversal by gene correction

2014 ◽  
Vol 62 ◽  
pp. 381-386 ◽  
Author(s):  
Laurie H. Sanders ◽  
Josée Laganière ◽  
Oliver Cooper ◽  
Sally K. Mak ◽  
B. Joseph Vu ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Dna Damage ◽  
Parkinson's Disease ◽  
Mitochondrial Dna ◽  
Neural Cells ◽  
Gene Correction ◽  
Mitochondrial Dna Damage

Lewy body pathology is associated with mitochondrial DNA damage in Parkinson's disease

2013 ◽  
Vol 34 (9) ◽  
pp. 2231-2233 ◽  
Author(s):  
Sarina K. Müller ◽  
Andreas Bender ◽  
Christoph Laub ◽  
Tobias Högen ◽  
Falk Schlaudraff ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Dna Damage ◽  
Parkinson's Disease ◽  
Mitochondrial Dna ◽  
Lewy Body ◽  
Mitochondrial Dna Damage ◽  
Lewy Body Pathology

scholarly journals Neuronal complex I deficiency occurs throughout the Parkinson’s disease brain, but is not associated with neurodegeneration or mitochondrial DNA damage

2017 ◽  
Vol 135 (3) ◽  
pp. 409-425 ◽  
Author(s):  
Irene H. Flønes ◽  
Erika Fernandez-Vizarra ◽  
Maria Lykouri ◽  
Brage Brakedal ◽  
Geir Olve Skeie ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Dna Damage ◽  
Parkinson's Disease ◽  
Mitochondrial Dna ◽  
Complex I ◽  
Mitochondrial Dna Damage ◽  
Complex I Deficiency

scholarly journals Simvastatin Inhibits the Activation of p21ras and Prevents the Loss of Dopaminergic Neurons in a Mouse Model of Parkinson's Disease

2009 ◽  
Vol 29 (43) ◽  
pp. 13543-13556 ◽  
Author(s):  
A. Ghosh ◽  
A. Roy ◽  
J. Matras ◽  
S. Brahmachari ◽  
H. E. Gendelman ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Mouse Model ◽  
Dopaminergic Neurons
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