scholarly journals Tetrodotoxin-Resistant Sodium Channels in Sensory Neurons Generate Slow Resurgent Currents That Are Enhanced by Inflammatory Mediators

2014 ◽  
Vol 34 (21) ◽  
pp. 7190-7197 ◽  
Author(s):  
Z.-Y. Tan ◽  
A. D. Piekarz ◽  
B. T. Priest ◽  
K. L. Knopp ◽  
J. L. Krajewski ◽  
...  
Keyword(s):  
Sodium Channels ◽  
Sensory Neurons ◽  
Inflammatory Mediators ◽  
Resurgent Currents

scholarly journals Sensory Neurons, Ion Channels, Inflammation and the Onset of Neuropathic Pain

2012 ◽  
Vol 39 (4) ◽  
pp. 416-435 ◽  
Author(s):  
Patrick L. Stemkowski ◽  
Peter A. Smith
Keyword(s):  
Spinal Cord ◽  
Neuropathic Pain ◽  
Peripheral Neuropathy ◽  
Pain Management ◽  
Sensory Neurons ◽  
Inflammatory Mediators ◽  
Primary Afferents ◽  
Ectopic Activity ◽  
Management Procedures

Neuropathic pain often fails to respond to conventional pain management procedures. here we review the aetiology of neuropathic pain as would result from peripheral neuropathy or injury. We show that inflammatory mediators released from damaged nerves and tissue are responsible for triggering ectopic activity in primary afferents and that this, in turn, provokes increased spinal cord activity and the development of ‘central sensitization’. Although evidence is mounting to support the role of interleukin-1β, prostaglandins and other cytokines in the onset of neuropathic pain, the clinical efficacy of drugs which antagonize or prevent the actions of these mediators is yet to be determined. basic science findings do, however, support the use of pre-emptive analgesia during procedures which involve nerve manipulation and the use of anti-inflammatory steroids as soon as possible following traumatic nerve injury.

scholarly journals Nav1.3 Sodium Channels: Rapid Repriming and Slow Closed-State Inactivation Display Quantitative Differences after Expression in a Mammalian Cell Line and in Spinal Sensory Neurons

2001 ◽  
Vol 21 (16) ◽  
pp. 5952-5961 ◽  
Author(s):  
Theodore R. Cummins ◽  
Fabio Aglieco ◽  
Mathurkrisnan Renganathan ◽  
Raimund I. Herzog ◽  
Sulayman D. Dib-Hajj ◽  
...  
Keyword(s):  
Cell Line ◽  
Sodium Channels ◽  
Mammalian Cell ◽  
Sensory Neurons ◽  
Mammalian Cell Line ◽  
Closed State

scholarly journals Secretion of Mast Cell Inflammatory Mediators Is Enhanced by CADM1-Dependent Adhesion to Sensory Neurons

2019 ◽  
Vol 13 ◽  
Author(s):  
Rania Magadmi ◽  
Judit Meszaros ◽  
Zoheir A. Damanhouri ◽  
Elizabeth P. Seward
Keyword(s):  
Mast Cell ◽  
Sensory Neurons ◽  
Inflammatory Mediators

The Effect of κ-Opioid Receptor Agonists on Tetrodotoxin-Resistant Sodium Channels in Primary Sensory Neurons

2009 ◽  
Vol 109 (2) ◽  
pp. 632-640 ◽  
Author(s):  
Xin Su ◽  
Neil A. Castle ◽  
Brett Antonio ◽  
Rosemarie Roeloffs ◽  
James B. Thomas ◽  
...  
Keyword(s):  
Opioid Receptor ◽  
Sodium Channels ◽  
Sensory Neurons ◽  
Primary Sensory Neurons ◽  
Receptor Agonists ◽  
Opioid Receptor Agonists

Effects of NMDA Receptor Antagonists on Voltage-Gated Tetrodotoxin Resistant Sodium Channels in Rat Sensory Neurons

2002 ◽  
Vol 96 (Sup 2) ◽  
pp. A846
Author(s):  
Shigeaki Tanahashi ◽  
Yoko Osawa ◽  
Akiyoshi Oda ◽  
Hiroki Iida ◽  
Shuji Dohi
Keyword(s):  
Nmda Receptor ◽  
Sodium Channels ◽  
Sensory Neurons ◽  
Nmda Receptor Antagonists ◽  
Receptor Antagonists ◽  
Voltage Gated

Somata of nerve-injured sensory neurons exhibit enhanced responses to inflammatory mediators

Pain ◽  
2003 ◽  
Vol 104 (3) ◽  
pp. 701-709 ◽  
Author(s):  
Xue-Jun Song ◽  
Jun-Ming Zhang ◽  
San-Jue Hu ◽  
Robert H LaMotte
Keyword(s):  
Sensory Neurons ◽  
Inflammatory Mediators
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