Impact of an Antibacterial Toothpaste as an Adjunct to Scaling and Root Planing on Gingivitis and the Relative Abundance of Periodontal Pathogens: A Three-Month Randomized Controlled Trial

2019 ◽  
Vol 15 (4) ◽  
pp. 195-201
Author(s):  
Kwang-Hak Bae ◽  
Hye-Sung Kim ◽  
Young-Youn Kim ◽  
Su-Jung Jo ◽  
Hyun-Jae Cho
Keyword(s):  
Randomized Controlled Trial ◽  
Relative Abundance ◽  
Controlled Trial ◽  
Scaling And Root Planing ◽  
Periodontal Pathogens ◽  
Randomized Controlled ◽  
Root Planing

scholarly journals Clinical efficacy of scaling and root planing with and without metronidazole on glycemic control: three-arm randomized controlled trial

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Ambrina Qureshi ◽  
Syed Akhtar Hussain Bokhari ◽  
Zeba Haque ◽  
Akhtar Ali Baloch ◽  
Sidra Zaheer
Keyword(s):  
Randomized Controlled Trial ◽  
Glycemic Control ◽  
Clinical Efficacy ◽  
Controlled Trial ◽  
Test Group ◽  
Periodontal Pocket ◽  
Outcome Variable ◽  
Scaling And Root Planing ◽  
Randomized Controlled ◽  
Root Planing

Abstract Background Treating periodontitis through non-surgical periodontal therapy (NSPT) may improve glycemic control in type-2 Diabetes Mellitus (T2DM) patients. However, the evidence to maintain this improvement beyond four months is insufficient. Hence, this trial was conducted to assess clinical efficacy of NSPT on glycemic control in T2DM patients. Methods This three-arm randomized controlled trial recruited 150 known T2DM participants (35–65 years), suffering from moderate to severe periodontitis, having HbA1c level ≥ 6.5% at baseline. Participants were followed up at 3 and 6 months. Intervention for test group-1 included scaling and root planing (SRP) with metronidazole (MET) and oral hygiene instructions (OHI). Test group-2 was intervened with SRP + OHI and control group with OHI only. Stata v. 14 was used to observe inter and intragroup mean changes in glycemic [glycated hemoglobin (HbA1c), fasting blood glucose (FBG)] and periodontal variables [bleeding on probing (BOP), periodontal pocket depth (PPD), clinical attachment loss (CAL)] using ANOVA and RMANOVA. Proportion of change in outcome variable (HbA1c) was assessed between treatment groups using chi-square test. Change was considered significant at p-value ≤ 0.05. Results A significant reduction was observed in BOP, PPD, CAL, HbA1c and FBG over time [p < 0.05]. Significant reductions were observed in same variables in both test groups in comparison to control arm [p < 0.05]. No change between the two test groups was observed [p > 0.05]. Conclusion Scaling and root planing improves glycemic control of T2DM patients independently of the use of MET. Therefore, SRP after every 6 months may be suggested and included as a part of overall diabetes management for patients suffering from T2DM. Clinical trial registration NCT 03,343,366 [Date of Registration: 17/11/2017]

Efficacy of Scaling and Root Planing with Photobiomodulation for Treating Periodontitis in Gutka Chewers: A Randomized Controlled Trial

2020 ◽  
Vol 38 (9) ◽  
pp. 545-551 ◽  
Author(s):  
Mohammed Al-Rabiah ◽  
Nawwaf Al-Hamoudi ◽  
Khulud Abdulrahman Al-Aali ◽  
Lonnie Slapar ◽  
Abdulaziz AlHelal ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Controlled Trial ◽  
Scaling And Root Planing ◽  
Randomized Controlled ◽  
Root Planing

Clinical and Microbiologic Evaluation of Scaling and Root Planing per Quadrant and One-Stage Full-Mouth Disinfection Associated With Azithromycin or Chlorhexidine: A Clinical Randomized Controlled Trial

2015 ◽  
Vol 86 (12) ◽  
pp. 1340-1351 ◽  
Author(s):  
Douglas Campideli Fonseca ◽  
José Roberto Cortelli ◽  
Sheila Cavalca Cortelli ◽  
Luís Otávio Miranda Cota ◽  
Lidiane Cristina Machado Costa ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Controlled Trial ◽  
Scaling And Root Planing ◽  
Randomized Controlled ◽  
One Stage ◽  
Root Planing ◽  
Full Mouth Disinfection

scholarly journals Efficacy of local use of probiotics as an adjunct to scaling and root planing in chronic periodontitis and halitosis: A randomized controlled trial

2016 ◽  
Vol 5 (2) ◽  
pp. 86 ◽  
Author(s):  
Soumya Penala ◽  
Butchibabu Kalakonda ◽  
KrishnajaneyaReddy Pathakota ◽  
Avula Jayakumar ◽  
Pradeep Koppolu ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Chronic Periodontitis ◽  
Controlled Trial ◽  
Scaling And Root Planing ◽  
Randomized Controlled ◽  
Root Planing ◽  
Local Use

scholarly journals Alpha-2-Macroglobulin Levels in Gingival Crevicular Fluid Pre- and Post-scaling and Root Planing with Adjunctive Tetracycline Fibers in Chronic Periodontitis: A Randomized Controlled Trial

2015 ◽  
Vol 16 (6) ◽  
pp. 474-478 ◽  
Author(s):  
Shivjot Chhina ◽  
Ajit Singh Rathore ◽  
Saurabh Juneja
Keyword(s):  
Randomized Controlled Trial ◽  
Chronic Periodontitis ◽  
Gingival Crevicular Fluid ◽  
Controlled Trial ◽  
Local Drug Delivery ◽  
Scaling And Root Planing ◽  
Randomized Controlled ◽  
Root Planing ◽  
Probing Depth ◽  
Crevicular Fluid

ABSTRACT Background This split-mouth clinical study aimed to investigate levels of alpha-2-macroglobulin (α2M) in gingival crevicular fluid (GCF) of chronic periodontitis patients pre- and post-scaling and root planing (SRP) with or without adjunctive use of tetracycline fibers. Materials and methods In 30 patients of chronic periodontitis, samples of GCF were collected from the gingival sulcus before SRP. Recording of clinical parameters was conducted. This was followed by local drug delivery (LDD) of tetracycline fibers in test sites. In control sites, no LDD was done. Second samples of GCF were taken 90 days after treatment. Samples of crevicular fluid were analyzed to determine the levels of α2m. Results A gain of clinical attachment (CAL) of 3.30 mm for SRP and LDD and for SRP alone was 1.62 mm (p < 0.001). The pocket probing depth was significantly decreased by 2.43 mm for SRP and LDD and for SRP alone was 1.61 mm (p < 0.001) after 90 days. Alpha-2-macroglobulin was significantly reduced in GCF by SRP and SRP and LDD after 90 days (p < 0.001). Conclusion Clinical and biochemical variables showed a more favorable outcome when SRP was combined with LDD of tetracycline fibers in management of patients suffering from chronic periodontitis. How to cite this article Chhina S, Rathore AS, Juneja S. Alpha-2-Macroglobulin Levels in Gingival Crevicular Fluid Pre- and Post-scaling and Root Planing with Adjunctive Tetracycline Fibers in Chronic Periodontitis: A Randomized Controlled Trial. J Contemp Dent Pract 2015;16(6):474-478.

scholarly journals Impact of Probiotics on the Salivary Microbiota and Salivary Levels of Inflammation-Related Proteins during Short-Term Sugar Stress: A Randomized Controlled Trial

Pathogens ◽  
2021 ◽  
Vol 10 (4) ◽  
pp. 392
Author(s):  
Christine Lundtorp-Olsen ◽  
Christian Enevold ◽  
Claus Antonio Juel Jensen ◽  
Steen Nymann Stofberg ◽  
Svante Twetman ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Relative Abundance ◽  
Controlled Trial ◽  
Oral Microbiome ◽  
Protective Effects ◽  
Short Term ◽  
Randomized Controlled ◽  
Rdna Sequencing ◽  
Salivary Microbiota ◽  
Related Proteins

Background: The purpose of the present investigation was to characterize the effect of probiotics on the composition of the salivary microbiota and salivary levels of inflammation-related proteins during short-term sugar stress. We tested the hypotheses that consumption of probiotics may partly counteract the detrimental influence of sugar stress on oral homeostasis. Methods: The present study was a five-week, blinded, randomized controlled trial with four study arms—A: sucrose and probiotic (n = 20); B: sucrose and placebo (n = 20); C: xylitol and probiotic (n = 20); D: xylitol and placebo (n = 20). Saliva samples were collected at baseline and after two and five weeks. The salivary microbiota was characterized by means of 16S rDNA sequencing, and sequences were referenced against the Human Oral Microbiome Database (HOMD). Neutrophil gelatinase-associated lipocalin (NGAL) and transferrin levels were quantified using immunoassays. Results: Sugar stress induced a significant increase in the relative abundance of the genus Streptococcus from 29.8% at baseline to 42.9% after two weeks. Changes were transient and were completely reversed three weeks after discontinuation of sugar stress. Xylitol and probiotics alone had no effect on the salivary microbiota, whereas the combination of xylitol and probiotics induced a significant decrease in the relative abundance of Streptococcus species from 37.6% at baseline to 23.0% at week 2. Sugar stress significantly increased salivary transferrin levels, and the effect was partly counteracted by concomitant use of probiotics. Conclusions: The data clearly demonstrate an impact of combined consumption of xylitol and probiotics on the composition of the salivary microbiota. Future studies are needed to evaluate whether the combined use of xylitol and the probiotic strains tested could have clinically protective effects during periods of sugar stress.

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