Allosteric inhibition of SHP2 uncovers aberrant TLR7 trafficking in aggravating psoriasis

EMBO Molecular Medicine ◽

10.15252/emmm.202114455 ◽

2021 ◽

Author(s):

Yuyu Zhu ◽

Zhigui Wu ◽

Wei Yan ◽

Fenli Shao ◽

Bowen Ke ◽

...

Keyword(s):

Allosteric Inhibition

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Faculty Opinions recommendation of Allosteric inhibition of protein tyrosine phosphatase 1B.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1020164.232545 ◽

2004 ◽

Author(s):

Wolfgang Jahnke

Keyword(s):

Protein Tyrosine Phosphatase ◽

Tyrosine Phosphatase ◽

Protein Tyrosine Phosphatase 1B ◽

Allosteric Inhibition ◽

Protein Tyrosine

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Faculty Opinions recommendation of Allosteric inhibition of protein tyrosine phosphatase 1B.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1020164.229476 ◽

2004 ◽

Author(s):

Stevan Hubbard

Keyword(s):

Protein Tyrosine Phosphatase ◽

Tyrosine Phosphatase ◽

Protein Tyrosine Phosphatase 1B ◽

Allosteric Inhibition ◽

Protein Tyrosine

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Faculty Opinions recommendation of Subunit-selective allosteric inhibition of glycine binding to NMDA receptors.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.716597815.792002815 ◽

2012 ◽

Author(s):

Johannes Hell

Keyword(s):

Nmda Receptors ◽

Allosteric Inhibition

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Faculty Opinions recommendation of 2.3 Å resolution cryo-EM structure of human p97 and mechanism of allosteric inhibition.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.726107428.793534650 ◽

2017 ◽

Author(s):

Tom Rapoport

Keyword(s):

Allosteric Inhibition

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Faculty Opinions recommendation of Allosteric inhibition of SHP2 phosphatase inhibits cancers driven by receptor tyrosine kinases.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.726472311.793521055 ◽

2016 ◽

Author(s):

Xiayang Qiu ◽

Ye Che

Keyword(s):

Tyrosine Kinases ◽

Receptor Tyrosine Kinases ◽

Allosteric Inhibition

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Allosteric inhibition of methylenetetrahydrofolate reductase by adenosylmethionine. Effects of adenosylmethionine and NADPH on the equilibrium between active and inactive forms of the enzyme and on the kinetics of approach to equilibrium.

Journal of Biological Chemistry ◽

10.1016/s0021-9258(18)61530-3 ◽

1987 ◽

Vol 262 (6) ◽

pp. 2485-2493 ◽

Author(s):

D.A. Jencks ◽

R.G. Mathews

Keyword(s):

Methylenetetrahydrofolate Reductase ◽

Approach To Equilibrium ◽

Allosteric Inhibition ◽

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The role of cysteine 206 in allosteric inhibition of Escherichia coli citrate synthase. Studies by chemical modification, site-directed mutagenesis, and 19F NMR.

Journal of Biological Chemistry ◽

10.1016/s0021-9258(18)54766-9 ◽

1991 ◽

Vol 266 (31) ◽

pp. 20709-20713

Author(s):

L.J. Donald ◽

B.R. Crane ◽

D.H. Anderson ◽

H.W. Duckworth

Keyword(s):

Escherichia Coli ◽

Chemical Modification ◽

Citrate Synthase ◽

Site Directed Mutagenesis ◽

19F Nmr ◽

Directed Mutagenesis ◽

Allosteric Inhibition

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Probing the Allosteric Inhibition Mechanism of a Spike Protein Using Molecular Dynamics Simulations and Active Compound Identifications

Journal of Medicinal Chemistry ◽

10.1021/acs.jmedchem.1c00320 ◽

2021 ◽

Author(s):

Qian Wang ◽

Lin Wang ◽

Yumin Zhang ◽

XiangLei Zhang ◽

Leike Zhang ◽

...

Keyword(s):

Molecular Dynamics ◽

Molecular Dynamics Simulations ◽

Active Compound ◽

Spike Protein ◽

Inhibition Mechanism ◽

Allosteric Inhibition ◽

Dynamics Simulations

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A study of the allosteric inhibition of HCV RNA-dependent RNA polymerase and implementing virtual screening for the selection of promising dual-site inhibitors with low resistance potential

Journal of Receptors and Signal Transduction ◽

10.1080/10799893.2016.1248293 ◽

2016 ◽

Vol 37 (4) ◽

pp. 341-354 ◽

Author(s):

Nasser S. M. Ismail ◽

Heba S. A. Elzahabi ◽

Peter Sabry ◽

Fady N. Baselious ◽

Andrew Samy AbdelMalak ◽

...

Keyword(s):

Virtual Screening ◽

Rna Polymerase ◽

Hcv Rna ◽

Rna Dependent Rna Polymerase ◽

Allosteric Inhibition ◽

Low Resistance ◽

Dual Site ◽

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A complex of N5,N10-methylenetetrahydrofolate dehydrogenase and N5,N10-methenyltetrahydrofolate cyclohydrolase in Escherichia coli. Purification, subunit structure, and allosteric inhibition by N10-formyltetrahydrofolate.

Journal of Biological Chemistry ◽

10.1016/s0021-9258(17)34711-7 ◽

1978 ◽

Vol 253 (12) ◽

pp. 4245-4253 ◽

Author(s):

I.K. Dev ◽

R.J. Harvey

Keyword(s):

Escherichia Coli ◽

Subunit Structure ◽

Allosteric Inhibition ◽

Methylenetetrahydrofolate Dehydrogenase

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