Bilateral extensive leg pyomyositis presenting with diabetic ketoacidosis

Pyomyositis is a rare and serious acute purulent bacterial infection of the skeletal muscle. Diabetes is the most important predisposing factor and, if left untreated, the infection has significant complications. We report the case of an adult male who presented acutely with a history of abdominal pain, nausea and vomiting and bilateral thigh pain. His abdominal examination was unremarkable, but a fluctuant swelling was identified in both thighs. Biochemical investigations revealed raised inflammatory markers and diagnostic chemistry of diabetic ketoacidosis. Pyomyositis was treated with intravenous antibiotics and surgical abscess drainage. MRI is the definitive investigation of choice to diagnose pyomyositis. Differential diagnoses include cellulitis, septic arthritis and deep vein thrombosis.

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Features of etiology and pathogenesis of acute deep vein thrombosis in children of different age groups. Results of a prospective cohort study in parallel groups

Kazan medical journal ◽

10.17816/kmj2019-410 ◽

2019 ◽

Vol 100 (3) ◽

pp. 410-415

Author(s):

I N Nurmeev ◽

L M Mirolubov ◽

L I Batyrshina ◽

N N Nurmeev ◽

M R Gilmutdinov ◽

...

Keyword(s):

Deep Vein Thrombosis ◽

Age Groups ◽

First Year ◽

Predisposing Factor ◽

Vein Thrombosis ◽

Venous Catheterization ◽

History Of ◽

Acute Deep Vein Thrombosis ◽

First Year Of Life ◽

Deep Vein

Aim. To study the characteristics of the etiology and clinical picture of acute deep vein thrombosis in children of different age groups. Methods. The article analyzes the diagnosis and treatment of 77 children and adolescents with acute deep vein thrombosis. The features of the history of patients, previous fact of deep venous catheterization were studied. The fact of the presence and absence of clinical symptoms of thrombosis is registered. The results of ultrasound diagnostics are used. All patients underwent a course of anticoagulant therapy. The results of diagnosis and treatment were evaluated taking into account the age of the patients, the presence/absence of the history of catheterization of deep veins. Results. When comparing different age groups, their distinctive characteristics were revealed: predominant presence of asymptomatic catheter-associated thrombosis in the younger age group (newborns and infants) with symptomatic deep vein thrombosis of various origin in older children. Among the surveyed, the majority (75.3%) had asymptomatic thrombosis. Pain (2.6%), edema (3.9%) and a combination of pain and edema (18.2%) were more common among symptomatic patients with the symptoms of acute vein thrombosis. In some cases, a combination of two or more complaints was noted. Asymptomatic thrombosis in the catheter-associated thrombosis group amounted to 96.6%. All patients below 1 year had a predisposing factor in the history: 95% - preceding vein catheterization, 5% - postoperative period. With a history of venous catheterization, symptoms of thrombosis were detected 9.2 times less frequently than in children without vein catheterization. In the group of children older than a year, the ratio of thrombosis without a predisposing factor was 10.5%, and the ratio of children with symptoms of thrombosis was 1.38 times higher than among children younger than a year. The only fatal outcome: a 17-year-old patient with a history of thrombophilia, thrombosis of the left iliac vein, pulmonary embolism. Conclusion. Deep vein thrombosis in children of the first year of life in all cases was caused by a predisposing factor: in children during the first year of life in 95% of cases deep vein thrombosis was asymptomatic and was revealed by ultrasound examination.

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A murine model of deep vein thrombosis Characterization and validation in transgenic mice

Thrombosis and Haemostasis ◽

10.1160/th05-03-0170 ◽

2005 ◽

Vol 94 (09) ◽

pp. 498-503 ◽

Cited By ~ 25

Author(s):

Linda Szema ◽

Chao-Ying Chen ◽

Jeffrey P. Schwab ◽

Gregory Schmeling ◽

Brian C. Cooley

Keyword(s):

Deep Vein Thrombosis ◽

Murine Model ◽

Femoral Vein ◽

Previous History ◽

Bed Rest ◽

Major Surgery ◽

Vein Thrombosis ◽

Transgenic Lines ◽

History Of ◽

Deep Vein

SummaryDeep vein thrombosis (DVT) occurs with high prevalence in association with a number of risk factors, including major surgery, trauma, obesity, bed rest (>5 days), cancer, a previous history of DVT, and several predisposing prothrombotic mutations. A novel murine model of DVT was developed for applications to preclinical studies of transgenically constructed prothrombotic lines and evaluation of new antithrombotic therapies. A transient direct-current electrical injury was induced in the common femoral vein of adult C57Bl/6 mice. A non-occlusive thrombus grew, peaking in size at 30 min, and regressing by 60 min, as revealed by histomorphometric volume reconstruction of the clot. Pre-heparinization greatly reduced clot formation at 10, 30, and 60 min (p<0.01 versus non-heparinized). Homozygous FactorV Leiden mice (analogous to the clinical FactorV Leiden prothrombotic mutation) on a C57Bl/6 background had clot volumes more than twice those of wild-types at 30 min (0.121±0.018 mm3 vs. 0.052±0.008 mm3, respectively; p<0.01). Scanning electron microscopy revealed a clot surface dominated by fibrin strands, in contrast to arterial thrombi which showed a platelet-dominated structure. This new model of DVT presents a quantifiable approach for evaluating thrombosis-related murine transgenic lines and for comparatively evaluating new pharmacologic approaches for prevention of DVT.

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Incidence and natural history of deep-vein thrombosis after total hip arthroplasty

Journal of Bone and Joint Surgery - British Volume ◽

10.1302/0301-620x.86b4.0860621 ◽

2004 ◽

Vol 86-B (4) ◽

pp. 621-621 ◽

Cited By ~ 1

Author(s):

F. T. HOAGLUND

Keyword(s):

Deep Vein Thrombosis ◽

Total Hip Arthroplasty ◽

Natural History ◽

Hip Arthroplasty ◽

Total Hip ◽

Vein Thrombosis ◽

History Of ◽

Deep Vein

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History of COVID-19 infection is not associated with increased d-dimer levels and risk of deep-vein thrombosis in total joint arthroplasty

Archives of Orthopaedic and Trauma Surgery ◽

10.1007/s00402-021-04181-8 ◽

2021 ◽

Author(s):

Anna Jungwirth-Weinberger ◽

Ilya Bendich ◽

Carola Hanreich ◽

Alejandro Gonzalez Della Valle ◽

Jason L. Blevins ◽

...

Keyword(s):

Deep Vein Thrombosis ◽

Total Joint Arthroplasty ◽

Joint Arthroplasty ◽

Vein Thrombosis ◽

History Of ◽

Deep Vein ◽

D Dimer

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NATURAL HISTORY OF POSTOPERATIVE DEEP-VEIN THROMBOSIS

The Lancet ◽

10.1016/s0140-6736(69)90355-9 ◽

1969 ◽

Vol 294 (7621) ◽

pp. 645 ◽

Cited By ~ 9

Author(s):

D. Negus ◽

D.J. Pinto

Keyword(s):

Deep Vein Thrombosis ◽

Natural History ◽

Vein Thrombosis ◽

Postoperative Deep Vein Thrombosis ◽

History Of ◽

Deep Vein

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23 Hidden: a hospice inpatient deep vein thrombosis detection study to explore the prevalence, symptom burden and natural history of venous thromboembolism in people with advanced cancer

10.1136/bmjspcare-2019-asp.22 ◽

2019 ◽

Author(s):

MJ Johnson ◽

SIR Noble ◽

F Swan ◽

V Allgar ◽

E Napier ◽

...

Keyword(s):

Deep Vein Thrombosis ◽

Venous Thromboembolism ◽

Natural History ◽

Advanced Cancer ◽

Symptom Burden ◽

Vein Thrombosis ◽

History Of ◽

Deep Vein

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Combined Venography And Arthrography In Patients With Joint Pains And A Swollen Calf

10.1055/s-0038-1653212 ◽

1981 ◽

Author(s):

J J F Belch ◽

N McMillan ◽

G D O Lowe ◽

C D Forbes

Keyword(s):

Deep Vein Thrombosis ◽

Clinical Diagnosis ◽

Joint Pain ◽

Correct Diagnosis ◽

Clinical Suspicion ◽

Baker’S Cyst ◽

Vein Thrombosis ◽

Baker's Cyst ◽

History Of ◽

Deep Vein

Ruptured Baker’s cyst is a well recognised cause of confusion in the diagnosis of deep vein thrombosis (D.V.T.) in patients with arthralgia. Many workers have stressed the need for a high index of clinical suspicion combined with either venography or arthrography, yet in no study has simultaneous arthrography and venography been performed. Ten patients with joint pains admitted because of a swollen calf underwent bilateral ascending venography and unilateral arthrography within 24 hours of admission. Results were compared with the initial clinical diagnosis. On only one out of 10 occasions was the original clinical diagnosis correct. One patient had a D.V.T. alone, 5 patients had a Baker’s cyst and 3 patients had both D.V.T. and Baker’s cyst. One patient had no evidence of either. We conclude that any patient with a history of joint pain who develops a swollen calf should have both a venogram and an arthrogram performed in order to establish the correct diagnosis.

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Symptomatic Deep Vein Thrombosis Following Elective Knee Arthroscopy Over the Age of 40

Clinical and Applied Thrombosis/Hemostasis ◽

10.1177/1076029619852167 ◽

2019 ◽

Vol 25 ◽

pp. 107602961985216 ◽

Cited By ~ 2

Author(s):

Mert Özcan ◽

Murat Erem ◽

Fatma Nesrin Turan

Keyword(s):

Risk Factors ◽

Deep Vein Thrombosis ◽

Medical History ◽

Symptomatic Deep Vein Thrombosis ◽

Vein Thrombosis ◽

Contraceptive Usage ◽

Venous Thromboembolic Events ◽

History Of ◽

Deep Vein ◽

Previous Medical History

Thromboprophylaxis following arthroscopic knee surgery (AKS) is not clear in the literature. The purpose of this study was to present the incidence of symptomatic deep vein thrombosis (DVT) following elective AKS over the age of 40. The secondary purpose was to investigate risk factors associated with venous thromboembolic events (VTEs). Surgical database and outpatient clinic follow-up charts of the patients who underwent AKS for any reason were included in the study. Odds for risk factors such as previous medical history of thrombosis, any family history for clotting disorders, diabetes mellitus (DM), oral contraceptive usage, body mass index, history of malignancy, and smoking were evaluated. The incidence of DVT following AKS significantly increased in the patients older than 40 years who had a previous medical history of VTE, DM, and smoking. A variety of guidelines exist for VTE prophylaxis; however, one should focus on risk factors related to the patient’s medical history and current medical conditions. In this study, smoking, DM, and previous history of DVT increased DVT risk significantly, and thromboprophylaxis should be kept in mind for these patients.

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