FURTHER STUDIES ON HEALTHY SUBJECTS WITH LOW AND HIGH INSULIN RESPONSE TO GLUCOSE INFUSION

1967 ◽  
Vol 55 (2) ◽  
pp. 305-329 ◽  
Author(s):  
Erol Cerasi ◽  
Rolf Luft
Keyword(s):  
Healthy Subjects ◽  
Insulin Response ◽  
Glucose Infusion ◽  
Oral Glucose ◽  
Intravenous Glucose ◽  
The Family ◽  
High Insulin ◽  
History Of ◽  
Insulin Response To Glucose ◽  
Plasma Insulin Response

ABSTRACT In a previous paper it was shown that 15 out of 85 healthy subjects with a normal intravenous glucose tolerance demonstrated a low plasma insulin response to glucose infusion which was similar to that obtained in diabetic subjects. In the present paper it has been shown that the type of insulin response to glucose infusion was the same when the test was repeated. Low insulin responders to glucose infusion, as a group, also showed low insulin response to intravenous tolbutamide and oral glucose. This indicates that the type of insulin response is characteristic for a given subject irrespective of the stimulation used. There seemed to be no difference in the occurrence of diabetes in the family history of the groups of low and high insulin responders.

STUDIES ON THE PATHOGENESIS OF DIABETES IN ACROMEGALY

1967 ◽  
Vol 56 (4) ◽  
pp. 593-607 ◽  
Author(s):  
Rolf Luft ◽  
Erol Cerasi ◽  
Carl Axel Hamberger
Keyword(s):  
Glucose Tolerance ◽  
Insulin Response ◽  
Normal Glucose Tolerance ◽  
Glucose Infusion ◽  
Intravenous Glucose ◽  
Highly Active ◽  
Normal Glucose ◽  
Insulin Response To Glucose ◽  
Active Acromegaly ◽  
Plasma Insulin Response

ABSTRACT Plasma insulin response to glucose infusion was found to be markedly increased in 20 patients with active acromegaly and with normal intravenous glucose tolerance. The insulin response was more pronounced in patients with highly active acromegaly than in those showing moderately active disease. In five patients with active acromegaly and with decreased glucose tolerance the insulin response was delayed and smaller than normal, i. e. similar to that seen in diabetic subjects without acromegaly. After successful treatment of the acromegaly insulin response to glucose infusion was normalized in the patients with normal glucose tolerance. In those with decreased glucose tolerance the diabetic type of insulin response remained unchanged even when the glucose tolerance was normalized. It is suggested that diabetes in connection with acromegaly develops only in prediabetic individuals, i.e. subjects with decreased insulin response to hyperglycaemia, who are unable to overcome the diabetogenic effect of growth hormone by compensatory hyperinsulinism.

INSULIN RESPONSE TO GLUCOSE INFUSION DURING PREGNANCY. A PROSPECTIVE STUDY OF HIGH AND LOW INSULIN RESPONDERS WITH NORMAL CARBOHYDRATE TOLERANCE

1974 ◽  
Vol 75 (1) ◽  
pp. 87-104 ◽  
Author(s):  
Karin Edström ◽  
Erol Cerasi ◽  
Rolf Luft
Keyword(s):  
Fasting Blood Glucose ◽  
Insulin Response ◽  
Glucose Infusion ◽  
Intravenous Glucose ◽  
K Value ◽  
Endogenous Insulin ◽  
High Insulin ◽  
Insulin Response To Glucose ◽  
A Prospective Study ◽  
Low Insulin Response

ABSTRACT A decreased insulin response to glucose administration has been suggested to be a prerequisite for the development of diabetes mellitus. Factors that increase the demand for insulin in the organism may precipitate diabetes in subjects with a low insulin response to a glucose infusion test (GIT). Since it is well-known that pregnancy is a diabetogenic factor, its effect on the carbohydrate metabolism of subjects with a low insulin response was studied. During pregnancy, the insulin response of the low responders was enhanced as in the controls, but at all stages the insulin response was significantly less than in the controls. None of the subjects developed glucose intolerance during pregnancy. The fasting blood glucose and plasma insulin levels and the k-value in intravenous glucose tolerance tests (IVGTT) were modified according to similar patterns in both groups. The sensitivity to endogenous insulin was significantly greater in the low insulin responders but was reduced to a greater extent than in the controls towards the end of pregnancy. In four of the 11 low insulin responders the initial insulin response to glucose in the last trimester was lower than in mid-pregnancy. This occurred only in one out of 14 high insulin responders. It is suggested that gestational diabetes occurs in those low insulin responders who demonstrate either a dramatic decrease in insulin sensitivity, or limitations in the enhancement of insulin release, or, more likely both conditions.

INSULIN RESPONSE TO GLUCOSE INFUSION IN DIABETIC AND NON-DIABETIC MONOZYGOTIC TWIN PAIRS. GENETIC CONTROL OF INSULIN RESPONSE?

1967 ◽  
Vol 55 (2) ◽  
pp. 330-345 ◽  
Author(s):  
Erol Cerasi ◽  
Rolf Luft
Keyword(s):  
Diabetes Mellitus ◽  
Chronic Pancreatitis ◽  
Healthy Subjects ◽  
Insulin Response ◽  
Monozygotic Twin ◽  
Glucose Infusion ◽  
Striking Similarity ◽  
Insulin Response To Glucose ◽  
Genetically Determined ◽  
Low Insulin Response

ABSTRACT The insulin response during a standardized glucose infusion (GIT) was studied in a group of 13 monozygotic twin pairs previously registered as consisting of one diabetic/one non-diabetic member. At the time of the study three of the non-diabetic subjects had developed overt diabetes and three decreased glucose tolerance only. Of the non-diabetic members all but one (with diabetes due possibly to chronic pancreatitis in the sibling) showed an insulin response similar to that seen in diabetic subjects, and in healthy subjects previously assumed to be potential diabetics. The present study therefore supports our earlier suggestion that a low insulin response characterizes potential diabetes. There was a striking similarity between the insulin curves in the twin pairs, irrespective whether diabetes occurred in one, in both or in none of the members. It is suggested as a working hypothesis that the type of insulin response to glucose infusion is genetically determined, and that a low insulin response is a prerequisite for the development of diabetes mellitus.

Significance of genetic factors for the plasma insulin response to glucose in healthy subjects

2008 ◽  
Vol 10 (3) ◽  
pp. 125-134 ◽  
Author(s):  
Jan Lindsten ◽  
Erol Cerasi ◽  
Rolf Luft ◽  
Newton Morton ◽  
Nils Ryman
Keyword(s):  
Healthy Subjects ◽  
Plasma Insulin ◽  
Genetic Factors ◽  
Insulin Response ◽  
Insulin Response To Glucose ◽  
Plasma Insulin Response

OBESITY AS AN ADDITIONAL FACTOR IN THE PATHOGENESIS OF DIABETES

1968 ◽  
Vol 59 (2) ◽  
pp. 344-352 ◽  
Author(s):  
Rolf Luft ◽  
Erol Cerasi ◽  
Bo Andersson
Keyword(s):  
Glucose Tolerance ◽  
Plasma Insulin ◽  
Peripheral Resistance ◽  
Insulin Response ◽  
Intravenous Glucose ◽  
Endogenous Insulin ◽  
Intravenous Glucose Tolerance ◽  
Obese Subjects ◽  
Insulin Response To Glucose ◽  
Plasma Insulin Response

ABSTRACT Plasma insulin response to glucose infusion was measured in obese subjects with normal and decreased intravenous glucose tolerance. In obese non-diabetic subjects there was insulin hyperresponsiveness to glucose accompanied by peripheral resistance to endogenous insulin. In the obese diabetic subjects insulin response was of the type seen in non-obese diabetics; in no such instance could insulin hyperresponsiveness to glucose be obtained. It is suggested that obesity precipitates diabetes only in subjects with preexisting impairment of insulin response, i. e. in prediabetics. Subjects with unimpaired insulin secreting capacity would overcome the diabetogenic effect of obesity by compensatory hyperinsulinism.

THE PLASMA INSULIN RESPONSE TO GLUCOSE INFUSION IN HEALTHY SUBJECTS AND IN DIABETES MELLITUS

1967 ◽  
Vol 55 (2) ◽  
pp. 278-304 ◽  
Author(s):  
Erol Cerasi ◽  
Rolf Luft
Keyword(s):  
Diabetes Mellitus ◽  
Glucose Tolerance ◽  
Healthy Subjects ◽  
Plasma Insulin ◽  
Insulin Response ◽  
Normal Glucose Tolerance ◽  
Glucose Infusion ◽  
Analogue Computer ◽  
Plasma Insulin Concentration ◽  
Plasma Insulin Response

ABSTRACT Plasma insulin concentration was measured during a standardized glucose infusion test (GIT) in 85 healthy subjects with a normal glucose tolerance and in 28 patients with manifest diabetes mellitus or decreased glucose tolerance. Each test was evaluated with the aid of an analogue computer model, and parameters characterizing different parts of the insulin curve during GIT were obtained. Large variations existed in all parameter values both in the normal and diabetic groups, and the overlapping between the two groups was considerable. In 15 out of 85 healthy subjects the plasma insulin response during GIT was of the diabetic type as judged from the frequency distribution of the computer parameters (low values). The similarity was still more striking when the characteristics of the insulin curves in these 15 subjects were compared with those in patients with mild diabetes or with a decreased glucose tolerance only. It is postulated that this type of low insulin response reflects a derangement of the release of insulin into the circulation, and that it marks an alteration which probably is a prerequisite for the development of diabetes mellitus. In this sense, these subjects may be considered to be potential diabetics.

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