TREATMENT OF HIRSUTISM AND OTHER SIGNS OF VIRILISM WITH A REVERSED SEQUENTIAL ADMINISTRATION OF CYPROTERONE ACETATE AND ETHINYL OESTRADIOL CLINICAL AND ENDOCRINOLOGICAL ASPECTS

1971 ◽  
Vol 68 (1_Supplb) ◽  
pp. S172 ◽  
Author(s):  
F. Zielske ◽  
I. Leo-Rossberg ◽  
R. Dreykluft ◽  
A. Römmler ◽  
J. Hammerstein
Keyword(s):  
Cyproterone Acetate ◽  
Sequential Administration ◽  
Ethinyl Oestradiol

THE EFFECTS OF CYPROTERONE ACETATE AND ETHINYL OESTRADIOL ON CARBOHYDRATE METABOLISM

1984 ◽  
Vol 21 (6) ◽  
pp. 689-699 ◽  
Author(s):  
M. SEED ◽  
I. F. GODSLAND ◽  
V. WYNN ◽  
H. S. JACOBS
Keyword(s):  
Carbohydrate Metabolism ◽  
Cyproterone Acetate ◽  
Ethinyl Oestradiol

THE INFLUENCE OF COMBINED CYPROTERONE ACETATE-ETHINYL OESTRADIOL THERAPY ON SERUM LEVELS OF DEHYDROEPIANDROSTERONE, ANDROSTENEDIONE, AND TESTOSTERONE IN HIRSUTE WOMEN

1977 ◽  
Vol 84 (2) ◽  
pp. 333-342 ◽  
Author(s):  
Marijke Frölich ◽  
Nadia Lachinsky ◽  
A. J. Moolenaar
Keyword(s):  
Linear Correlation ◽  
Cyproterone Acetate ◽  
Polycystic Ovary ◽  
Serum Levels ◽  
Ovary Syndrome ◽  
Testosterone Levels ◽  
Normal Women ◽  
Peripheral Conversion ◽  
Ethinyl Oestradiol

ABSTRACT Serum levels of dehydroepiandrosterone, androstenedione, and testosterone in hirsute women suffering from either idiopathic hirsutism or the polycystic ovary syndrome were determined before and during treatment with cyproterone acetate combined with ethinyl oestradiol. During this treatment the hirsutism decreased markedly. In untreated hirsute women serum dehydroepiandrosterone levels do not differ from those in normal women and do not change during therapy; androstenedione levels are higher than normal and decrease markedly during treatment, and the testosterone levels are elevated compared to normals, with a considerable overlap, and show only a tendency to decrease. There is no correlation between dehydroepiandrosterone and androstenedione levels or between androstenedione and testosterone levels in the serum of untreated hirsute women. After 12–14 months of cyproterone acetate-ethinyl oestradiol therapy a linear correlation is found between dehydroepiandrosterone and androstenedione levels. This can be explained by the relatively higher contribution of the peripheral conversion of dehydroepiandrosterone to androstenedione to the occurrence of lower androstenedione levels. The linear correlation between androstenedione and testosterone after treatment, also found in normal women, indicates the restoration of the role of androstenedione as the major peripheral precursor of testosterone.

EFFECT OF CYPROTERONE ACETATE-ETHINYL OESTRADIOL TREATMENT ON ADRENAL FUNCTION IN HIRSUTE WOMEN

1982 ◽  
Vol 17 (6) ◽  
pp. 577-582 ◽  
Author(s):  
M. G. CHAPMAN ◽  
S. L. JEFFCOATE and ◽  
C. J. DEWHURST
Keyword(s):  
Cyproterone Acetate ◽  
Adrenal Function ◽  
Oestradiol Treatment ◽  
Ethinyl Oestradiol

THE INTERACTION OF DIHYDROTESTOSTERONE AND OESTRADIOL-17β WITH MACROMOLECULES IN HUMAN HYPERPLASTIC PROSTATE TISSUE

1974 ◽  
Vol 76 (4) ◽  
pp. 773-782 ◽  
Author(s):  
H. M. Fraser ◽  
Angela J. H. Mitchell ◽  
C. K. Anderson ◽  
R. E. Oakey
Keyword(s):  
Cyproterone Acetate ◽  
Prostate Tissue ◽  
Cytosol Fraction ◽  
Oestrone Sulphate ◽  
Ethinyl Oestradiol

ABSTRACT During incubation of minced human hyperplastic prostate tissue with [3H]5α-dihydrotestosterone (27 nm), 3H became firmly bound to macromolecules in both cytosol and nucleus. The binding to the cytosol fraction was inhibited when oestradiol-17β (0.3 μm), oestrone sulphate, ethinyl-oestradiol-17β or diethylstilboestrol (10 μm) was included in the incubation. Binding to the nuclei was inhibited by incubation with oestradiol-17β (1 μm) or cyproterone acetate (6.5 μm), a potent anti-androgen, but not by incubation with cortisol (30 μm).

CASE REPORT: Toxic Hepatitis After Sequential Administration of Flutamide and Cyproterone Acetate

2004 ◽  
Vol 49 (3) ◽  
pp. 462-465 ◽  
Author(s):  
Spilios Manolakopoulos ◽  
Sotirios Bethanis ◽  
Anastasios Armonis ◽  
Michalis Economou ◽  
Alec Avgerinos ◽  
...  
Keyword(s):  
Case Report ◽  
Cyproterone Acetate ◽  
Toxic Hepatitis ◽  
Sequential Administration
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