REVERSAL BY INSULIN TREATMENT OF ABNORMAL GROWTH HORMONE PATTERN IN NEWLY DIAGNOSED DIABETES MELLITUS

1974 ◽  
Vol 77 (1) ◽  
pp. 115-121 ◽  
Author(s):  
R. J. Corrall ◽  
W. M. Hunter ◽  
I. W. Campbell ◽  
A. D. B. Harrower ◽  
L. J. P. Duncan ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Insulin Therapy ◽  
Hormone Secretion ◽  
Growth Hormone Secretion ◽  
Newly Diagnosed ◽  
Abnormal Growth ◽  
Insulin Dependent ◽  
Abnormal Pattern ◽  
Insulin Dependent Diabetic ◽  
Diagnosed Diabetes

ABSTRACT The effect of insulin therapy on growth hormone secretion was studied in five newly diagnosed young insulin-dependent diabetic men. All showed a markedly abnormal pattern of secretion immediately prior to insulin therapy and following "normalization" of the blood glucose there was a significant fall in plasma growth hormone levels after a period of one to two months though these were still considerably elevated above the normal control range. These findings lend support to the view that the abnormal growth hormone secretion observed in diabetes may be the consequence rather than the cause of the disordered carbohydrate metabolism.

Nocturnal versus diurnal hormonal counterregulation to hypoglycemia in Type 1 (insulin-dependent) diabetic patients

1993 ◽  
Vol 128 (2) ◽  
pp. 109-115 ◽  
Author(s):  
Inger Bendtson ◽  
Anne Mette Rosenfalck ◽  
Christian Binder
Keyword(s):  
Growth Hormone ◽  
Blood Glucose ◽  
Insulin Infusion ◽  
Hormone Secretion ◽  
Growth Hormone Secretion ◽  
Diabetic Patients ◽  
Hormonal Responses ◽  
Nocturnal Hypoglycemia ◽  
Insulin Dependent ◽  
Insulin Dependent Diabetic

Asymptomatic hypoglycemia in IDDM patients seems to be more frequent during the night than during the day, with reported frequencies as high as 56%. Hormonal counterregulation to diurnal and nocturnal hypoglycemia was studied in 10 insulin-dependent diabetic patients without diabetic complications in order to test whether hormonal responses were lower at night than during daytime. A lower catecholamine response might imply less marked symptoms and therefore one reason why patients are not awakened by hypoglycemia. Blood glucose was stabilized to around 6 mmol/1 by iv insulin infusion and hypoglycemia was induced by increasing the insulin infusion rate—in the night studies at 01.30, in the day studies at 08.00. Blood glucose nadirs were 1.5±0.4 (1.2–1.9) mmol/1 at night and 1.9±0.3 (1.3–2.2) mmol/l during the day; in three patients the nadirs were identical during both the night and day. One patient had no adrenaline response to daytime hypoglycemia. In general, nocturnal hypoglycemia elicited greater catecholamine responses correlated to the duration of hypoglycemia. Glucagon responses showed a great heterogeneity independently of diabetes duration and hypoglycemic level. Growth hormone secretion was reduced during the night study; however, no refractory periods were found after sleep-related growth hormone secretion. In conclusion: counter-regulatory hormonal responses tend to be greater at night than during the day and do not explain why patients are not awakened by nocturnal hypoglycemia.

scholarly journals Dawn phenomenon in Type 1 (insulin-dependent) diabetic adolescents: influence of nocturnal growth hormone secretion

Diabetologia ◽  
1988 ◽  
Vol 31 (8) ◽  
pp. 607-611 ◽  
Author(s):  
B. Beaufr�re ◽  
M. Beylot ◽  
C. Metz ◽  
A. Ruitton ◽  
R. Fran�ois ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Hormone Secretion ◽  
Growth Hormone Secretion ◽  
Dawn Phenomenon ◽  
Insulin Dependent ◽  
Insulin Dependent Diabetic

Human Growth Hormone Secretion after Double Stimulation with Arginine in Normal and Insulin-dependent Diabetic Women

Diabetes ◽  
1973 ◽  
Vol 22 (9) ◽  
pp. 694-705 ◽  
Author(s):  
L. Koncz ◽  
J. S. Soeldner ◽  
M. C. Balodimos ◽  
G. Boden ◽  
R. E. Gleason ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Human Growth Hormone ◽  
Hormone Secretion ◽  
Growth Hormone Secretion ◽  
Human Growth ◽  
Insulin Dependent ◽  
Insulin Dependent Diabetic ◽  
Double Stimulation

Specific abnormalities in a visual motor psychological test in short children with abnormal growth hormone secretion

1997 ◽  
Vol 86 (2) ◽  
pp. 154-159 ◽  
Author(s):  
A Andronikof-Sanglade ◽  
A Fjellestad-Paulsen ◽  
S Ricard-Malivoir ◽  
D Evain-Brion
Keyword(s):  
Growth Hormone ◽  
Hormone Secretion ◽  
Growth Hormone Secretion ◽  
Psychological Test ◽  
Abnormal Growth ◽  
Short Children ◽  
Visual Motor
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