OESTROGEN TREATMENT AND SUBSEQUENT PREGNANCY IN TWO PATIENTS WITH SEVERE HYPERGONADOTROPHIC OVARIAN FAILURE

1978 ◽  
Vol 89 (1) ◽  
pp. 149-157 ◽  
Author(s):  
J. Starup ◽  
J. Philip ◽  
V. Sele
Keyword(s):  
Ovarian Failure ◽  
Subsequent Pregnancy ◽  
Premature Menopause ◽  
Turner's Syndrome ◽  
Turner’S Syndrome ◽  
Substitution Therapy ◽  
Oestrogen Treatment

ABSTRACT This report describes in detail the histological and hormonal findings in a patient with Turner's syndrome (45,XO) and a patient with premature menopause (46,XX), who both conceived after withdrawal or reduction of substitution therapy with oestrogens. The aetiology of severe hypergonadotrophic ovarian failure is discussed, and theories regarding a possible relationship between the oestrogen treatment and subsequent pregnancy are hypothesized.

Effects of luteinizing hormone-releasing hormone (LRH) upon bioactive and immunoreactive serum LH in patients with Turner's syndrome before and after oestrogen treatment

1985 ◽  
Vol 109 (3) ◽  
pp. 304-308 ◽  
Author(s):  
Marco Francesco Celani ◽  
Vanna Montanini ◽  
Paolo Marrama
Keyword(s):  
Biologically Active ◽  
Delayed Response ◽  
Turner's Syndrome ◽  
Turner’S Syndrome ◽  
Oestrogen Treatment ◽  
Serum Lh ◽  
Before And After ◽  
The Mean ◽  
Ethinyl Oestradiol

Abstract. One daily dose of 0.05 mg ethinyl oestradiol was administered to 5 patients with Turner's syndrome (mean age ± sem = 16.4 ± 0.7 years) for 10 days. The effects of acute stimulation with luteinizing hormonereleasing hormone (LRH) (0.1 mg iv) on biologically active and immunoreactive LH were analysed before therapy and at the end of oestrogen treatment. Bioactive LH (BIO-LH) was measured by a sensitive and specific in vitro bioassay based upon testosterone production by mechanically dispersed mouse Leydig cell preparations. Immunoreactive LH (RIA-LH) was evaluated by a double antibody RIA method. Prior to oestrogen treatment, LRH induced a prompt rise in BIO-LH and RIA-LH levels, which reached peak values at 30 and 45 min, respectively. After oestrogen treatment, a delayed response (with peak values at 120 min) was observed for both BIO-LH and RIA-LH. Before oestrogen treatment, the mean bioactivity to immunoreactivity (B/I) ratio of LRH-stimulated LH showed a significant decrease from basal values (P < 0.05). In contrast, after ethinyl oestradiol administration the mean LH B/I ratio increased significantly from basal values in response to LRH (P < 0.05). The mean relative maximum response (Δ%) for BIO-LH was significantly higher (P < 0.05) in oestrogen-treated than in untreated patients, whereas the mean BIO-LH Δ area was significantly lower in the former group (P < 0.01). Similarly, oestrogens decreased significantly the mean RIA-LH Δ area (P < 0.05), whereas they did not affect significantly the mean RIA-LH Δ%. The results further emphasize that oestrogens may change the quality of circulating LH.

The Effects of Low Doses of Depot Estradiol and Testosterone in Teenagers with Ovarian Failure and Turner's Syndrome

1973 ◽  
Vol 37 (4) ◽  
pp. 574-580 ◽  
Author(s):  
ROBERT L. ROSENFIELD ◽  
VICTOR S. FANG ◽  
CARYN DUPON ◽  
MOON H. KIM ◽  
SAMUEL REFETOFF
Keyword(s):  
Ovarian Failure ◽  
Turner's Syndrome ◽  
Low Doses ◽  
Turner’S Syndrome

Influence of estrogen administration on growth hormone response to GHRH and L-Dopa in patients with Turner's syndrome

1989 ◽  
Vol 120 (4) ◽  
pp. 442-446 ◽  
Author(s):  
E. Schober ◽  
H Frisch ◽  
F. Waldhauser ◽  
Ch. Bieglmayr
Keyword(s):  
Growth Hormone ◽  
Priming Effect ◽  
Ovarian Failure ◽  
Estrogen Deficiency ◽  
Growth Hormone Response ◽  
Turner's Syndrome ◽  
Hormone Response ◽  
Turner’S Syndrome ◽  
Gh Secretion ◽  
Estrogen Administration

Abstract. The modulating effect of estrogen on GH secretion was studied in 22 patients with Turner's syndrome. Estrogen administration (0.5 μg/kg ethinylestradiol) for a period of 4 weeks resulted in a significant increase in basal GH concentrations (2.6 vs 4.8 μg/l, P< 0.01). The L-Dopa-stimulated GH concentrations were also significantly increased (P< 0.01), whereas no effect of estrogen substitution on GH responses to GHRH (1–44) and Sm-C levels was seen. Our findings demonstrate a priming effect of estrogen on GH secretion in patients with Turner's syndrome. These patients generally lack the puberty-associated rise in GH secretion, which might be due to ovarian failure and the concomitant estrogen deficiency.

Scanning and Transmission Electron Microscopy of the Endometrium in Women with Ovarian Dysgenesis (Turner'S Syndrome)

1976 ◽  
Vol 34 ◽  
pp. 148-149
Author(s):  
A. González-Angulo ◽  
S. Armendares-Sagrera ◽  
I. Ruíz de Chávez ◽  
H. Marquez-Monter ◽  
R. Aznar
Keyword(s):  
Surface Epithelium ◽  
Secretory Cells ◽  
Turner's Syndrome ◽  
Ciliated Cells ◽  
Turner’S Syndrome ◽  
Exogenous Hormone ◽  
Ovarian Dysgenesis ◽  
Transmission Electron ◽  
Normal Women ◽  
Microscopy Examination

It is a well documented fact that endometrial hyperplasia and adenocarcinoma may develop in women with Turner's syndrome who had received unopposed estrogen treatment (1), as well as in normal women under contraceptive medication with the sequential regime (2). The purpose of the present study was to characterize the possible changes in surface and glandular epithelium in these women who were treated with a sequential regime for a period of between three and eight years. The aim was to find organelle modifications which may lead to the understanding of the biology of an endometrium under exogenous hormone stimulation. Light microscopy examination of endometrial biopsies of nine patients disclosed a proliferative pattern; in two of these, there was focal hyperplasia. With the scanning electron microscope the surface epithelium in all biopsies showed secretory cells with microvilli alternating with non secretory ciliated cells. Regardless of the day of the cycle all biopsies disclosed a large number of secretory cells rich in microvilli (fig.l) with long and slender projections some of which were branching (fig. 2).

ON THE FREQUENCY OF MALFORMATIONS IN THE DIFFERENT FORMS OF TURNER'S SYNDROME

1974 ◽  
Vol 77 (1_Suppl) ◽  
pp. S48 ◽  
Author(s):  
F. Majewski ◽  
J. R. Bierich ◽  
M. Barz ◽  
W. F. Haberlandt ◽  
M. Stoeckenius
Keyword(s):  
Turner's Syndrome ◽  
Turner’S Syndrome
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