Immunohistochemical localization of sex-hormone-binding globulin in normal breast tissue and breast carcinoma

1989 ◽  
Vol 120 (3_Suppl) ◽  
pp. S165-S166
Author(s):  
G. SINNECKER ◽  
O. HIORT ◽  
P. W. L. KWAN ◽  
R. A. DELELLIS
Keyword(s):  
Breast Carcinoma ◽  
Breast Tissue ◽  
Normal Breast Tissue ◽  
Normal Breast ◽  
Immunohistochemical Localization ◽  
Sex Hormone ◽  
Sex Hormone Binding Globulin ◽  
Hormone Binding

Localization of hyaluronan in normal breast tissue, radial scar, and tubular breast carcinoma

1993 ◽  
Vol 24 (12) ◽  
pp. 1294-1297 ◽  
Author(s):  
Manuel de la Torre ◽  
Alvin F. Wells ◽  
Jonas Bergh ◽  
Anders Lindgren
Keyword(s):  
Breast Carcinoma ◽  
Breast Tissue ◽  
Normal Breast Tissue ◽  
Normal Breast ◽  
Radial Scar ◽  
Tubular Breast

DESMOLASE ACTIVITY OF NORMAL AND MALIGNANT HUMAN BREAST TISSUE

1969 ◽  
Vol 44 (1) ◽  
pp. 69-77 ◽  
Author(s):  
J. B. ADAMS ◽  
M. S. F. WONG
Keyword(s):  
Breast Carcinoma ◽  
Breast Tissue ◽  
Normal Breast Tissue ◽  
Radical Mastectomy ◽  
Normal Breast ◽  
Acetone Powder ◽  
Human Breast ◽  
Carcinoma Tissue ◽  
Mastectomy Specimen ◽  
Powder Fraction

SUMMARY [4-14C]Cholesterol was cleaved to pregnenolone and progesterone by a washed particulate fraction isolated from involved lymph nodes obtained from a radical mastectomy specimen. Difficulties were experienced in isolating subcellular fractions from primary breast tumours and normal breast tissue. However, an acetone powder fraction, obtained from normal tissue derived from a radical mastectomy specimen, yielded pregnenolone from [4-14C]cholesterol. [7α-3H]17α-Hydroxyprogesterone was converted to androstenedione and to 17α,20α-dihydroxypregn-4-en-3-one and its 17α,20β-epimer by homogenates of secondary breast carcinoma tissue and normal breast tissue obtained from radical mastectomy specimens. These results, in conjunction with those obtained previously (Adams & Wong, 1968a), show that human breast carcinoma tissue contains the enzymes necessary to convert cholesterol to androgens and oestrogens.

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