Localization of hyaluronan in normal breast tissue, radial scar, and tubular breast carcinoma

1993 ◽  
Vol 24 (12) ◽  
pp. 1294-1297 ◽  
Author(s):  
Manuel de la Torre ◽  
Alvin F. Wells ◽  
Jonas Bergh ◽  
Anders Lindgren
Keyword(s):  
Breast Carcinoma ◽  
Breast Tissue ◽  
Normal Breast Tissue ◽  
Normal Breast ◽  
Radial Scar ◽  
Tubular Breast

DESMOLASE ACTIVITY OF NORMAL AND MALIGNANT HUMAN BREAST TISSUE

1969 ◽  
Vol 44 (1) ◽  
pp. 69-77 ◽  
Author(s):  
J. B. ADAMS ◽  
M. S. F. WONG
Keyword(s):  
Breast Carcinoma ◽  
Breast Tissue ◽  
Normal Breast Tissue ◽  
Radical Mastectomy ◽  
Normal Breast ◽  
Acetone Powder ◽  
Human Breast ◽  
Carcinoma Tissue ◽  
Mastectomy Specimen ◽  
Powder Fraction

SUMMARY [4-14C]Cholesterol was cleaved to pregnenolone and progesterone by a washed particulate fraction isolated from involved lymph nodes obtained from a radical mastectomy specimen. Difficulties were experienced in isolating subcellular fractions from primary breast tumours and normal breast tissue. However, an acetone powder fraction, obtained from normal tissue derived from a radical mastectomy specimen, yielded pregnenolone from [4-14C]cholesterol. [7α-3H]17α-Hydroxyprogesterone was converted to androstenedione and to 17α,20α-dihydroxypregn-4-en-3-one and its 17α,20β-epimer by homogenates of secondary breast carcinoma tissue and normal breast tissue obtained from radical mastectomy specimens. These results, in conjunction with those obtained previously (Adams & Wong, 1968a), show that human breast carcinoma tissue contains the enzymes necessary to convert cholesterol to androgens and oestrogens.

scholarly journals Hormone Receptor Expression Variations in Normal Breast Tissue: Preliminary Results of a Prospective Observational Study

2021 ◽  
Vol 11 (5) ◽  
pp. 387
Author(s):  
Giacomo Santandrea ◽  
Chiara Bellarosa ◽  
Dino Gibertoni ◽  
Maria C. Cucchi ◽  
Alejandro M. Sanchez ◽  
...  
Keyword(s):  
Hormone Receptor ◽  
Breast Tissue ◽  
Normal Breast Tissue ◽  
Normal Breast ◽  
Receptor Expression ◽  
Hormonal Stimulation ◽  
Tissue Samples ◽  
Hormonal Receptor ◽  
Hormone Receptor Expression ◽  
Cystic Disease Fluid Protein

Normal breast tissue undergoes great variations during a woman’s life as a consequence of the different hormonal stimulation. The purpose of the present study was to examine the hormonal receptor expression variations according to age, menstrual cycle, menopausal state and body mass index. To this purpose, 49 tissue samples of normal breast tissue, obtained during surgery performed for benign and malignant conditions, were immunostained with Estrogen (ER), Progesterone (PR) and Androgen receptors (AR). In addition, Ki67 and Gross Cystic Disease Fluid Protein were studied. The data obtained revealed a great variability of hormone receptor expression. ER and AR generally increased in older and post-menopausal women, while young women presented a higher proliferative rate, evaluated with Ki67. PR increase was observed in women with BMI higher than 25. The different hormonal receptor expression could favor the development of breast cancer.

scholarly journals Expression of c-kit protein in cancer versus normal breast tissue

2012 ◽  
Vol 4 ◽  
pp. 306-309 ◽  
Author(s):  
Abdolhassan Talaiezadeh ◽  
Seyed Nematollah Jazayeri ◽  
Jamal Nateghi
Keyword(s):  
Breast Tissue ◽  
Normal Breast Tissue ◽  
Normal Breast
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