Vertebral fractures are more prevalent than long bone fractures in boys with glucocorticoid-treated Duchenne Muscular Dystrophy: Results of a prospective observational study

2019 ◽  
Author(s):  
Stefan A Jackowski ◽  
Laura C McAdam ◽  
Jinhui Ma ◽  
Hugh J McMillan ◽  
Victor N Konji ◽  
...  
Keyword(s):  
Duchenne Muscular Dystrophy ◽  
Muscular Dystrophy ◽  
Observational Study ◽  
Vertebral Fractures ◽  
Prospective Observational Study ◽  
Bone Fractures ◽  
Long Bone ◽  
Long Bone Fractures

scholarly journals Serum periostin levels following small bone fractures, long bone fractures and joint replacements: an observational study

2018 ◽  
Vol 14 (1) ◽  
Author(s):  
Rachel Varughese ◽  
Ruth Semprini ◽  
Claire Munro ◽  
James Fingleton ◽  
Cecile Holweg ◽  
...  
Keyword(s):  
Observational Study ◽  
Bone Fractures ◽  
Long Bone ◽  
Joint Replacements ◽  
Long Bone Fractures ◽  
Serum Periostin ◽  
Small Bone

The 2+2 Rule in the Management of Long Bone Fractures in Patients with Severe Multiple Trauma

2009 ◽  
Vol 81 (11) ◽  
Author(s):  
Leszek Brongel ◽  
Wiesław Jarzynowski ◽  
Piotr Budzyński ◽  
Waldemar Hładki ◽  
Jacek Lorkowski ◽  
...  
Keyword(s):  
Multiple Trauma ◽  
Bone Fractures ◽  
Long Bone ◽  
Severe Multiple Trauma ◽  
Long Bone Fractures

Advances in the management of long bone fractures

2016 ◽  
Vol 2016 (2) ◽  
pp. 12-14
Author(s):  
Toby Gemmill ◽  
Dylan Clements
Keyword(s):  
Bone Fractures ◽  
Long Bone ◽  
Long Bone Fractures

Bone density and bone health alteration in boys with Duchenne Muscular Dystrophy: a prospective observational study

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Renu Suthar ◽  
B. V. Chaithanya Reddy ◽  
Manisha Malviya ◽  
Titiksha Sirari ◽  
Savita Verma Attri ◽  
...  
Keyword(s):  
Lumbar Spine ◽  
Bone Health ◽  
Prospective Observational Study ◽  
Bone Fractures ◽  
Long Bone ◽  
Vertebral Compression Fractures ◽  
Serum Osteocalcin ◽  
Z Score ◽  
X Ray ◽  
Compression Fractures

Abstract Objectives Boys with Duchenne Muscular Dystrophy (DMD) are at increased risk for compromised bone health, manifesting as low-impact trauma long bone fractures and vertebral compression fractures. Methods In a prospective observational study, we studied bone health parameters in North Indian boys with DMD. We consecutively enrolled ambulatory boys with DMD on glucocorticoid therapy. Bone health was evaluated with X-ray spine, Dual-energy X-ray absorptiometry (DXA), serum calcium, vitamin D3 (25[OH]D), 1,25-dihyroxyvitamin D3 (1,25[OH]2D3), serum osteocalcin, osteopontin, and N terminal telopeptide of type 1 collagen (Ntx) levels. Results A total of 76 boys with DMD were enrolled. The median age was 8.5 (interquartile range [IQR] 7.04–10.77) years. Among these, seven (9.2%) boys had long bone fractures, and four (5.3%) had vertebral compression fractures. Fifty-four (71%) boys underwent DXA scan, and among these 31 (57%) had low bone mineral density (BMD, ≤−2 z-score) at the lumbar spine. The mean BMD z-score at the lumbar spine was −2.3 (95% confidence interval [CI] = −1.8, −2.8), and at the femoral neck was −2.5 (95% CI = −2, −2.9). 25(OH)D levels were deficient in 68 (89.5%, n=76) boys, and 1,25(OH)2D3 levels were deficient in all. Mean serum osteocalcin levels were 0.68 ± 0.38 ng/mL (n=54), serum osteopontin levels were 8.6 ± 4.6 pg/mL (n=54) and serum Ntx levels were 891 ± 476 nmol/L (n=54). Boys with low BMD received glucocorticoids for longer duration, in comparison to those with normal BMD (median, IQR [16.9 (6–34) months vs. 7.8 (4.8–13.4) months]; p=0.04). Conclusions Bone health is compromised in North Indian boys with DMD. BMD at the lumbar spine is reduced in more than half of boys with DMD and nearly all had vitamin D deficiency on regular vitamin D supplements. Longer duration of glucocorticoid therapy is a risk factor for low BMD in our cohort.

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