scholarly journals Papillary thyroid carcinoma with tall cell features is as aggressive as tall cell variant: a meta-analysis

2018 ◽  
Vol 7 (12) ◽  
pp. R286-R293 ◽  
Author(s):  
Huy Gia Vuong ◽  
Nguyen Phuoc Long ◽  
Nguyen Hoang Anh ◽  
Tran Diem Nghi ◽  
Mai Van Hieu ◽  
...  

There are still ongoing debates as to which cut-off percentage of tall cell (TC) should be used to define tall cell variant (TCV) papillary thyroid carcinoma (PTC). In this meta-analysis, we aimed to investigate the clinicopathological significance of PTC with tall cell features (PTC-TCF, PTC with 10–50% of TCs) in comparison with classical PTC and TCVPTC (PTC with more than 50% of TCs) to clarify the controversial issue. Four electronic databases including PubMed, Web of Science, Scopus and Virtual Health Library were accessed to search for relevant articles. We extracted data from published studies and pooled into odds ratio (OR) and its corresponding 95% confidence intervals (CIs) using random-effect modeling. Nine studies comprising 403 TCVPTCs, 325 PTC-TCFs and 3552 classical PTCs were included for meta-analyses. Overall, the clinicopathological profiles of PTC-TCF including multifocality, extrathyroidal extension, lymph node metastasis, distant metastasis and patient mortality were not statistically different from those of TCVPTC. Additionally, PTC-TCF and TCVPTC were both associated with an increased risk for aggressive clinical courses as compared to classical PTC. The prevalence of BRAF mutation in PTC-TCF and TCVPTC was comparable and both were significantly higher than that in classical PTC. The present meta-analysis demonstrated that even a PTC comprising only 10% of TCs might be associated with a poor clinical outcome. Therefore, the proportions of PTC in PTC should be carefully estimated and reported even when the TC component is as little as 10%.

2020 ◽  
Vol 10 (1) ◽  
pp. 70
Author(s):  
Alessandro Longheu ◽  
Gian Luigi Canu ◽  
Federico Cappellacci ◽  
Enrico Erdas ◽  
Fabio Medas ◽  
...  

Background: The aim of this retrospective study was to investigate clinical and pathological characteristics of the tall cell variant of papillary thyroid carcinoma compared to conventional variants. Methods: The clinical records of patients who underwent surgical treatment between 2009 and 2015 were analyzed. The patients were divided into two groups: those with a histopathological diagnosis of tall cell papillary carcinoma were included in Group A, and those with a diagnosis of conventional variants in Group B. Results: A total of 35 patients were included in Group A and 316 in Group B. All patients underwent total thyroidectomy. Central compartment and lateral cervical lymph node dissection were performed more frequently in Group A (42.8% vs. 18%, p = 0.001, and 17.1% vs. 6.9%, p = 0.04). Angiolymphatic invasion, parenchymal invasion, extrathyroidal extension, and lymph node metastases were more frequent in Group A, and the data reached statistical significance. Local recurrence was more frequent in Group A (17.1% vs. 6.3%, p = 0.02), with two patients (5.7%) in Group A showing visceral metastases, whereas no patient in Group B developed metastatic cancer (p = 0.009). Conclusions: Tall cell papillary carcinoma is the most frequent aggressive variant of papillary thyroid cancer. Tall cell histology represents an independent poor prognostic factor compared to conventional variants.


2019 ◽  
pp. 225-228
Author(s):  
Miyoko Higuchi ◽  
Mitsuyoshi Hirokawa ◽  
Seiji Kuma

2018 ◽  
Vol 30 (1) ◽  
pp. 43-48 ◽  
Author(s):  
Kristine S. Wong ◽  
Sara E. Higgins ◽  
Ellen Marqusee ◽  
Matthew A. Nehs ◽  
Trevor Angell ◽  
...  

Thyroid ◽  
2008 ◽  
Vol 18 (11) ◽  
pp. 1179-1181 ◽  
Author(s):  
Ronald Ghossein ◽  
Virginia A. Livolsi

Thyroid ◽  
2010 ◽  
Vol 20 (2) ◽  
pp. 153-158 ◽  
Author(s):  
Luc G.T. Morris ◽  
Ashok R. Shaha ◽  
R. Michael Tuttle ◽  
Andrew G. Sikora ◽  
Ian Ganly

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