scholarly journals THERAPY IN ENDOCRINE DISEASE: Etomidate in the management of hypercortisolaemia in Cushing's syndrome: a review

2012 ◽  
Vol 167 (2) ◽  
pp. 137-143 ◽  
Author(s):  
Veronica A Preda ◽  
Jonathan Sen ◽  
Niki Karavitaki ◽  
Ashley B Grossman

This review addresses the practical usage of intravenous etomidate as a medical therapy in Cushing's syndrome. We reviewed the relevant literature, using search terms ‘etomidate’, ‘Cushing's syndrome’, ‘adrenocortical hyperfunction’, ‘drug therapy’ and ‘hypercortisolaemia’ in a series of public databases. There is a paucity of large randomised controlled trials, and data on its use rely only on small series, case study reports and international consensus guideline recommendations. Based on these, etomidate is an effective parenteral medication for the management of endogenous hypercortisolaemia, particularly in cases with significant biochemical disturbance, sepsis and other serious complications such as severe psychosis, as well as in preoperative instability. We suggest treatment protocols for the safe and effective use of etomidate in Cushing's syndrome.

2022 ◽  
pp. 988-996
Author(s):  
Lisa Beutelspacher ◽  
Agnes Mainka ◽  
Tobias Siebenlist

Participatory smartphone apps empower citizens to interact with the city's administration. The purpose of this case study is to investigate the current state of participatory apps in Germany. Within this study, we examined 248 applications aimed at strengthening citizen participation. These apps were found in Google Playstore and Apple Appstore using search terms extracted from the relevant literature. Many of the apps give users the opportunity to report problems within their cities, such as broken street lamps or potholes. The information created and disseminated by the citizens through the app mainly includes the topics “mobility” and “environment.” Information provided by the city itself is much more diverse. Topics such as “Points of Interest,” “News and Events,” “Government” or “City Services” can be identified here. In the southern part of Germany, there is a significantly larger number of municipalities which have a citizen participation app. None of the apps examined uses gamification, although the use of game elements is very promising to foster the engagement and motivation of citizens.


1981 ◽  
Vol 28 (2) ◽  
pp. 225-230 ◽  
Author(s):  
MITSUO INADA ◽  
SHUNICHIRO KURATA ◽  
MITSUSHIGE NISHIKAWA ◽  
MARIKO OISHI ◽  
YASUO MASHIO ◽  
...  

2010 ◽  
Vol 163 (1) ◽  
pp. 9-13 ◽  
Author(s):  
Laurence Guignat ◽  
Jérôme Bertherat

Cushing's syndrome is considered a rare disease and its diagnosis can be challenging. Establishment of evidence-based recommendations is difficult. In 2008, several national and international consensus recommendations for the diagnosis or management of Cushing's syndrome were reported. The Endocrine Society, with the participation of the European Society of Endocrinology, has developed a task force to update recommendations for the diagnosis of Cushing's syndrome. The main aspects of these recommendations are presented in this article and discussed in the context of current research efforts in Europe focusing on the improvement of diagnosis and management of rare diseases including adrenal disorders such as Cushing's syndrome.


2018 ◽  
Vol 14 (4) ◽  
pp. 18-26 ◽  
Author(s):  
Lisa Beutelspacher ◽  
Agnes Mainka ◽  
Tobias Siebenlist

Participatory smartphone apps empower citizens to interact with the city's administration. The purpose of this case study is to investigate the current state of participatory apps in Germany. Within this study, we examined 248 applications aimed at strengthening citizen participation. These apps were found in Google Playstore and Apple Appstore using search terms extracted from the relevant literature. Many of the apps give users the opportunity to report problems within their cities, such as broken street lamps or potholes. The information created and disseminated by the citizens through the app mainly includes the topics “mobility” and “environment.” Information provided by the city itself is much more diverse. Topics such as “Points of Interest,” “News and Events,” “Government” or “City Services” can be identified here. In the southern part of Germany, there is a significantly larger number of municipalities which have a citizen participation app. None of the apps examined uses gamification, although the use of game elements is very promising to foster the engagement and motivation of citizens.


2018 ◽  
Vol 64 (4) ◽  
pp. 450-456
Author(s):  
Jana Kollerová ◽  
Ján Malina ◽  
Andrej Šteňo ◽  
Pavol Povinec ◽  
Juraj Payer

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