scholarly journals Association of HDL-C and apolipoprotein A-I with the risk of type 2 diabetes in subjects with impaired fasting glucose

2014 ◽  
Vol 171 (1) ◽  
pp. 137-142 ◽  
Author(s):  
You-Cheol Hwang ◽  
Hong-Yup Ahn ◽  
Sung-Woo Park ◽  
Cheol-Young Park
Keyword(s):  
Insulin Resistance ◽  
Blood Pressure ◽  
Type 2 Diabetes ◽  
Impaired Fasting Glucose ◽  
Fasting Glucose ◽  
Metabolic Profiles ◽  
Current Smoking ◽  
Apolipoprotein A ◽  
Incident Cases

ObjectivesHDLs have many diverse functions. The goal of this study was to determine the association of HDL cholesterol (HDL-C) and apolipoprotein A-I (apoA-I) with the development of type 2 diabetes (T2D). In particular, this study determined the association between the ratio of HDL-C to apoA-I (HA) and incident T2D.Design and methodsA total of 27 988 subjects with impaired fasting glucose (IFG) (18 266 men and 9722 women) aged 21–91 years (mean age 40.7 years) were followed for a mean duration of 2.81 years.ResultsStudy subjects were divided into quartiles according to the baseline HA ratio. Age, male sex, current smoking, BMI, waist circumference, and high-sensitivity C-reactive protein decreased across the quartiles, and all metabolic profiles, including blood pressure, fasting glucose, insulin resistance as determined by homeostasis model assessment of insulin resistance, and lipid measurements such as total cholesterol, LDL cholesterol, non-HDL-C, and apoB, improved as the HA ratio increased. In addition, incident cases of T2D decreased as the HA ratio increased, independent of age, sex, BMI, current smoking, systolic blood pressure, HbA1c, fasting serum insulin, family history of diabetes, and serum triglyceride concentrations (HR (95% CI) of fourth quartile vs first quartile; 0.76 (0.67–0.86), P<0.0001).ConclusionsA higher HA ratio was associated with favorable metabolic profiles and a lower risk of T2D development in subjects with IFG.

scholarly journals Blood Pressure Targets in Subjects With Type 2 Diabetes Mellitus/Impaired Fasting Glucose

Circulation ◽  
2011 ◽  
Vol 123 (24) ◽  
pp. 2799-2810 ◽  
Author(s):  
Sripal Bangalore ◽  
Sunil Kumar ◽  
Iryna Lobach ◽  
Franz H. Messerli
Keyword(s):  
Diabetes Mellitus ◽  
Blood Pressure ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Impaired Fasting Glucose ◽  
Fasting Glucose ◽  
Blood Pressure Targets

scholarly journals Impaired fasting glucose, type 2 diabetes mellitus, and lifetime risk of cardiovascular disease among women and men: the Rotterdam Study

2021 ◽  
Vol 9 (1) ◽  
pp. e002406
Author(s):  
Fariba Ahmadizar ◽  
Kan Wang ◽  
Elif Aribas ◽  
Lana Fani ◽  
Alis Heshmatollah ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Cardiovascular Disease ◽  
Type 2 Diabetes Mellitus ◽  
Impaired Fasting Glucose ◽  
Fasting Glucose ◽  
Lifetime Risk ◽  
Rotterdam Study ◽  
Incident Cases

IntroductionData on sex-specific lifetime risk of cardiovascular disease (CVD) across the glycemic spectrum, in particular in impaired fasting glucose (IFG) state, are scarce. Whether overweight/obesity modifies the CVD burden also remains unclear.Research design and methodsUsing a prospective population-based Rotterdam Study, normoglycemia, IFG, and type 2 diabetes mellitus (T2D) were defined. First incident cases of coronary heart disease, heart failure, and stroke during a follow-up time until January 1, 2015 were identified and formed the composite CVD end point. The remaining lifetime risks of CVD were estimated in each glucose category at 55, 65, 75, and 85 years of age, using a modified version of survival analysis adjusted for the competing risk of death.ResultsAmong 5698 women and 3803 men free of CVD at baseline, the mean age was 64.5 years (SD 9.6) and 60.0% of participants were women. At age 55 years, the remaining lifetime risk of any CVD event among women was 55.1% (95% CI 48.3 to 61.9) for IFG, compared with 52.7% (95% CI 49.5 to 55.9) for normoglycemia and 61.5% (95% CI 54.7 to 68.3) for T2D. For men, the remaining lifetime risk of any CVD event was 62.1% (95% CI 55.2 to 69.1) for IFG, compared with 59.1% (95% CI 55.5 to 62.7) for normoglycemia and 60.3% (95% CI 53.1 to 67.5) for T2D. At age 55 years, the lifetime risk for incident CVD was higher, although not statistically significant, among women and men with IFG who were overweight or had obesity compared with normal-weight women and men.ConclusionIFG carried a large lifetime risk for incident CVD among both women and men compared with normoglycemia. In particular among men, the risk was comparable to that of T2D. Overweight/Obesity modifies the risk and conferred a larger burden of lifetime CVD risk among women and men with IFG.

GLP-1 and peptide YY secretory response after fat load is impaired by insulin resistance, impaired fasting glucose and type 2 diabetes in morbidly obese subjects

2013 ◽  
Vol 80 (5) ◽  
pp. 671-676 ◽  
Author(s):  
José C. Fernández-García ◽  
Mora Murri ◽  
Leticia Coin-Aragüez ◽  
Juan Alcaide ◽  
Rajaa El Bekay ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Impaired Fasting Glucose ◽  
Peptide Yy ◽  
Fasting Glucose ◽  
Secretory Response ◽  
Morbidly Obese ◽  
Obese Subjects
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