Coronary artery disease risk in Chinese type 2 diabetics: is there a role for paraxonase 1 gene (Q192R) polymorphism?

OBJECTIVE: Heredity plays an important role in the predisposition to atherosclerotic coronary artery disease (CAD), and its thrombotic complications. Paraoxonase, a high-density lipoprotein-associated enzyme capable of hydrolyzing lipid peroxides, is presumed to contribute to atherosclerosis and CAD. This study investigates the role of human paraoxonase 1 (PON 1) gene (Q192R) polymorphism in CAD risk among Chinese type 2 diabetic cases. DESIGN: A population-based case-control study of paraoxonase 1 gene (Q192R) polymorphism and the risk of CAD in Chinese type 2 diabetics. METHODS: Subjects included 201 angiographically documented CAD patients with type 2 diabetes and 231 control subjects with type 2 diabetes alone living in central China. Single strand conformational polymorphism (SSCP) analysis was used to screen for PON 1 gene (Q192R) polymorphism. RESULTS: Frequency of the R allele was 21.5% in the CAD patients and 12.0% in the control subjects. The presence of the R allele was significantly associated with risk of CAD (odds ratio (OR)=1.97; 95% confidence interval (CI)=1.36--2.86). CONCLUSION: Frequency of the 192R allele of the human paraoxonase 1 gene may be an independent risk factor for CAD in the Chinese type 2 diabetics studied.

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Paraoxonase 1 gene (Q192R) polymorphism confers susceptibility to coronary artery disease in type 2 diabetes patients: Evidence from case-control studies

Drug Discoveries & Therapeutics ◽

10.5582/ddt.2019.01003 ◽

2019 ◽

Vol 13 (2) ◽

pp. 80-88 ◽

Cited By ~ 1

Author(s):

Xiaowei Huo ◽

Yuan Guo ◽

Yongjian Zhang ◽

Jieqiong Li ◽

Xiulin Wen ◽

...

Keyword(s):

Type 2 Diabetes ◽

Coronary Artery Disease ◽

Coronary Artery ◽

Case Control ◽

Paraoxonase 1 ◽

Case Control Studies ◽

Q192r Polymorphism ◽

Artery Disease ◽

Diabetes Patients

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GW26-e5437 Association of elevated apoA-I glycation and reduced HDL-associated paraoxonase 1, 3 activity, and their interaction with angiographic severity of coronary artery disease in patients with type 2 diabetes mellitus

Journal of the American College of Cardiology ◽

10.1016/j.jacc.2015.06.481 ◽

2015 ◽

Vol 66 (16) ◽

pp. C124

Author(s):

Ying Shen ◽

Fenghua Ding ◽

Jiateng Sun ◽

Ruiyan Zhang ◽

Qi Zhang ◽

...

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Coronary Artery Disease ◽

Type 2 Diabetes Mellitus ◽

Coronary Artery ◽

Paraoxonase 1 ◽

Artery Disease

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The Relationship Between Adiponectin Serum Level and Coronary Artery Disease in Type 2 Diabetic Patients

ACTA MEDICA IRANICA ◽

10.18502/acta.v59i3.5784 ◽

2021 ◽

Author(s):

Zahra Mazloum Khorasani ◽

Saeed Choobkar ◽

Ramin Khameneh Bagheri ◽

Mina AkbariRad ◽

Abdollah Firoozi

Keyword(s):

Type 2 Diabetes ◽

Coronary Artery Disease ◽

Coronary Artery ◽

Serum Level ◽

Demographic Data ◽

Diabetic Patients ◽

Type 2 Diabetics ◽

Increased Risk ◽

Artery Disease

Adiponectin is an adipocytokine that has a higher serum level in healthy people. In type 2 diabetes, insulin resistance, hypertension, MI, and dyslipidemia, the serum level of adiponectin is lower than 4 µg/mL. Adiponectin is proved to have a protective role against atherosclerotic changes where its low serum levels in type 2 diabetes can lead to the progression of atherosclerotic lesions. In this study, we aimed to survey the possible effects of adiponectin in the development of coronary artery disease in type 2 diabetics. Thirty diabetic cases with coronary artery disease, 30 diabetic cases without known coronary artery disease, and a group of 30 healthy volunteers, all of them were between 18-65-year-old, were entered ourstudy. We gathered demographic data by performing a physical examination followed by filling a checklist and a set of laboratory tests. All the groups were sex and age-matched (P=0.284 and P=0.163 respectively). CAD group had the lowest HBA1C (P<0.001). Both LDL and HDL were also lower in the CAD group (P<0.001). Adiponectin was also lower in the CAD group when compared to other groups (P<0.008) or when compared with only normal diabetics (P<0.002). We found a correlation between adiponectin and HDL (r=0.348, P=0.008), suggesting each unit of reduction in serum level of adiponectin could increase the chance of coronary artery disease by 38% in diabetics. In this study, we showed that the lower serum level of adiponectin is correlated with an increased risk of coronary artery disease in type 2 diabetics.

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