scholarly journals Biochemical markers of bone turnover and their relation to forearm bone mineral density in persons of Pakistani and Norwegian background living in Oslo, Norway: The Oslo Health Study

2006 ◽  
Vol 155 (5) ◽  
pp. 693-699 ◽  
Author(s):  
Kristin Holvik ◽  
Haakon E Meyer ◽  
Anne Johanne Søgaard ◽  
Randi Selmer ◽  
Egil Haug ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Vitamin D ◽  
Bone Turnover ◽  
Secondary Hyperparathyroidism ◽  
Ethnic Groups ◽  
Bone Mineral ◽  
Community Dwelling ◽  
Inverse Association ◽  
Mineral Density ◽  
Men And Women

Objective: To evaluate whether Pakistanis have increased bone turnover compared with ethnic Norwegians due to their high prevalence of vitamin D deficiency and secondary hyperparathyroidism, and whether the relation between bone turnover and bone mineral density (BMD) differs between Pakistanis and ethnic Norwegians. Design: A cross-sectional, population-based study conducted in the city of Oslo in 2000–2001. Random samples of 132 community-dwelling Pakistani men and women of ages 40, 45, and 59–60 years, and 580 community-dwelling Norwegian men and women of ages 45 and 59–60 years are included in this substudy. Methods: Venous serum samples were drawn for measurements of markers of the vitamin D endocrine system and the bone turnover markers osteocalcin (s-OC), bone alkaline phosphatase (s-bone ALP), and tartrate-resistant acid phosphatase (s-TRACP). BMD was measured at the forearm by single-energy X-ray absorptiometry. Results: Pakistanis had higher s-bone ALP compared with Norwegians. Mean (95% CI) age-adjusted levels were 22.5 (21.0, 24.1) U/l in Pakistani men versus 19.3 (18.6, 20.1) U/l in Norwegian men, P < 0.0005, and 20.3 (18.4, 22.1) U/l in Pakistani women versus 16.7 (16.0, 17.4) U/l in Norwegian women, P = 0.001. There tended to be an inverse association between bone turnover and BMD in men and women of both ethnic groups, and it was strongest for s-bone ALP. Overall mean (95% CI) distal BMD decrease was −16 (−20, −11) mg/cm2 per 1 s.d. increase in s-bone ALP (P < 0.0005) when adjusting for age, sex, and ethnicity. Conclusions: Except for somewhat higher s-bone ALP levels in Pakistanis, there were only minor ethnic differences in bone turnover, despite a strikingly different prevalence of secondary hyperparathyroidism. Bone turnover was inversely associated with forearm BMD in both ethnic groups.

scholarly journals Vitamin D deficiency, secondary hyperparathyroidism and bone mineral density in Pakistani and Norwegians living in Oslo, Norway / Vitamin D-mangel, sekundær hyperparathyroidisme og bentetthet hos pakistanere og nordmenn bosatt i Oslo

2009 ◽  
Vol 16 (2) ◽  
Author(s):  
Kari Alvær ◽  
Kristin Holvik ◽  
Anne Johanne Søgaard ◽  
Jan A. Falch ◽  
Haakon E. Meyer
Keyword(s):  
Bone Mineral Density ◽  
Vitamin D ◽  
Secondary Hyperparathyroidism ◽  
Vitamin D Deficiency ◽  
Bone Mineral ◽  
Vitamin D Status ◽  
Mineral Density ◽  
Men And Women ◽  
Skeletal Size ◽  
Pakistani Women

<p>We studied the prevalence of vitamin D deficiency and bone mineral density in Norwegian born and Pakistani born men and women living in Oslo. We measured 25-hydroxyvitamin D, iPTH and ionized calcium in serum and bone mineral density (BMD) at the forearm with single energy X-ray absorptiometry. 1386 persons born in Norway and 177 persons born in Pakistan participated. Among the Pakistani born 9% of the men and 21% of women were seriously vitamin D deficient (25(OH)D < 12.5 nmol/l). None of the Norwegian born had such low levels of vitamin D. While 86% of the Norwegians were vitamin D sufficient (25(OH)D ! 50 nmol/l), only 8% of Pakistani men and 10% of Pakistani women had a sufficient vitamin D status. The prevalence of secondary hyperparathyroidism was four times higher in Pakistani women and five times higher in Pakistani men compared to their Norwegian counterparts. Unadjusted bone mineral density was not different between the two ethnic groups, but in the multivariate analysis BMD was 0.020 g/cm<sup>2</sup> (95% CI: 0.007–0.033) higher in Pakistani men than in Norwegian men. We also found 5-8% higher bone mineral density in Pakistani men and women when we controlled for different skeletal size. While BMD was lower in Norwegian women with, compared to Norwegian women without, secondary hyperparathyroidsm (–0.027 g/cm<sup>2</sup>, p = 0.019), there was no difference in BMD between Pakistani women with and without secondary hyperparathyroidsm</p><p>Vi har sett på prevalens av vitamin D-mangel og bentetthet hos norskfødte og pakistanskfødte menn og kvinner i den populasjonsbaserte Helseundersøkelsen i Oslo 2000-2001. Det ble målt 25-hydroksyvitamin D, iPTH og ionisert kalsium i serum, og benmineraltetthet (BMD) ble målt i underarmen. Totalt deltok 1386 personer født i Norge og 177 personer født i Pakistan i aldersgruppen 30-75 år. Blant pakistanske menn og kvinner hadde henholdsvis 8% og 10% tilfredsstillende vitamin D-status (25(OH)D ! 50 nmol/l), mens 9% og 21% hadde alvorlig vitamin D-mangel (25(OH)D < 12,5 nmol/l). Blant personer født i Norge hadde 86% tilfredsstillende vitamin D-status og ingen hadde alvorlig vitamin D-mangel. Prevalensen av sekundær hyperparatyreoidisme var 4 ganger høyere hos pakistanske kvinner og 5 ganger høyere hos pakistanske menn enn hos norske kvinner og menn. Ujustert benmineraltetthet var ikke forskjellig hos pakistanere og nordmenn, men justert for andre risikofaktorer fant vi 0,020 g/cm<sup>2</sup> (95% CI: 0,007–0,033) høyere BMD hos pakistanske menn enn hos norske menn. Tilsvarende fant vi opptil 5-8% høyere bentetthet hos pakistanere enn nordmenn når vi korrigerte for ulik skjelettstørrelse i de to gruppene. Videre fant vi en positiv sammenheng mellom 25(OH)D og BMD hos norske kvinner (r = 0,11, p = 0,019) og norske menn (r = 0,16, p = 0,002). En svakere sammenheng ble funnet hos pakistanske menn, mens vi ikke fant noen assosiasjon hos pakistanske kvinner. Tilsvarende hadde de norske kvinnene med sekundær hyperparatyreoidisme lavere BMD enn norske kvinner uten sekundær hyperparatyreoidisme (–0,027 g/cm<sup>2</sup>, p = 0,019). Samme tendens ble også observert for både pakistanske og norske menn, men ikke for pakistanske kvinner.</p>

scholarly journals Inverse association of carotenoid intakes with 4-y change in bone mineral density in elderly men and women: the Framingham Osteoporosis Study

2008 ◽  
Vol 89 (1) ◽  
pp. 416-424 ◽  
Author(s):  
Shivani Sahni ◽  
Marian T Hannan ◽  
Jeffrey Blumberg ◽  
L Adrienne Cupples ◽  
Douglas P Kiel ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Inverse Association ◽  
Mineral Density ◽  
Elderly Men ◽  
Men And Women

Bone turnover marker determinants in young women: results from the Safe-D study

2017 ◽  
Vol 55 (3) ◽  
pp. 328-340 ◽  
Author(s):  
Emma T Callegari ◽  
Suzanne M Garland ◽  
Alexandra Gorelik ◽  
Cherie Y Chiang ◽  
John D Wark
Keyword(s):  
Bone Mineral Density ◽  
Body Composition ◽  
Bone Turnover ◽  
Bone Mineral ◽  
Young Women ◽  
Bone Health ◽  
Community Dwelling ◽  
Hormonal Contraceptives ◽  
Mineral Density

Background Bone turnover markers (BTMs) may provide insight into bone health in young women, but have been little studied in this demographic. We aimed to explore the association between body composition, hormonal contraception, bone mineral density and biochemical parameters and BTMs in young women. Methods Participants were community-dwelling females aged 16–25 years, living in Victoria, Australia. Carboxy-terminal cross-linking telopeptide of type 1 collagen (CTX) and total procollagen type 1 N-propeptide (P1NP) were analysed on the Roche Elecsys automated analyzer. A total of 305 were evaluated, after excluding participants with medical conditions or medications (except hormonal contraceptives), which may affect bone metabolism. Results Median (Q1, Q3) BTM values were 540 (410, 690) ng/L for CTX and 61.7 (46.2, 83.7) µg/L for P1NP. Serum CTX and P1NP were inversely associated with chronological age ( P < 0.001), transferrin ( P < 0.020) and serum dehydroepiandrosterone sulphate concentration ( P < 0.001). BTM values were up to 22% lower in combined oral contraceptive (COC) pill users ( P < 0.001). Serum CTX was inversely associated with per cent body fat ( P = 0.009) and tibial cortical volumetric bone mineral density (vBMD; P = 0.003). Serum P1NP concentrations were 23  µg/L higher in participants who reported using an osteopath in the previous year ( P = 0.007). Conclusions These data suggest that BTMs are influenced by age, COC use, body composition, iron status and hormonal profiles. Higher CTX values were associated with lower tibial cortical vBMD. Examining BTMs in relation to interventions aimed at improving bone health in young women is warranted.

Sign in / Sign up

Export Citation Format

Share Document