The truncated somatostatin receptor sst5TMD4 stimulates the production of pro-angiogenic factors in in vitro and in vivo breast cancer models

2014 ◽  
Author(s):  
Raul M Luque ◽  
Mario Duran-Prado ◽  
David Rincon-Fernandez ◽  
Marta Hergueta-Redondo ◽  
Michael D Culler ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Somatostatin Receptor ◽  
Angiogenic Factors ◽  
Cancer Models

scholarly journals Anticancer Activity of Andrographolide Semisynthetic Derivatives

2010 ◽  
Vol 5 (5) ◽  
pp. 1934578X1000500 ◽  
Author(s):  
Vidya Menon ◽  
Sujata Bhat
Keyword(s):  
Breast Cancer ◽  
Antitumor Activity ◽  
Myeloid Leukemia ◽  
Cancer Cell Line ◽  
Maximum Activity ◽  
In Vitro Activity ◽  
Cancer Models ◽  
In Vivo Antitumor Activity

Andrographolide 1, a diterpene lactone of Andrographis paniculata, displays in vitro and in vivo antitumor activity against breast cancer models and mouse myeloid leukemia (M1) cells. In the present study, we report the semi-synthesis of andrographolide derivatives and their in vitro activity against A549 (ATCC) (NSCL cancer) cell line. Amongst the derivatives tested, compounds 3- 5 displayed maximum activity, with IC50 values of 22-31 μg/mL.

scholarly journals Ginsenoside Rg3: Potential Molecular Targets and Therapeutic Indication in Metastatic Breast Cancer

Medicines ◽  
2019 ◽  
Vol 6 (1) ◽  
pp. 17 ◽  
Author(s):  
Maryam Nakhjavani ◽  
Jennifer E Hardingham ◽  
Helen M Palethorpe ◽  
Yoko Tomita ◽  
Eric Smith ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Treatment ◽  
Metastatic Breast ◽  
Therapeutic Agents ◽  
Ginsenoside Rg3 ◽  
Cancer Models ◽  
Anti Cancer ◽  
Ginseng Plant

Breast cancer is still one of the most prevalent cancers and a leading cause of cancer death worldwide. The key challenge with cancer treatment is the choice of the best therapeutic agents with the least possible toxicities on the patient. Recently, attention has been drawn to herbal compounds, in particular ginsenosides, extracted from the root of the Ginseng plant. In various studies, significant anti-cancer properties of ginsenosides have been reported in different cancers. The mode of action of ginsenoside Rg3 (Rg3) in in vitro and in vivo breast cancer models and its value as an anti-cancer treatment for breast cancer will be reviewed.

scholarly journals The Antioxidant N-Acetylcysteine Prevents HIF-1 Stabilization under Hypoxia In Vitro but Does Not Affect Tumorigenesis in Multiple Breast Cancer Models In Vivo

PLoS ONE ◽  
2013 ◽  
Vol 8 (6) ◽  
pp. e66388 ◽  
Author(s):  
Jaclyn Sceneay ◽  
Mira C. P. Liu ◽  
Anna Chen ◽  
Christina S. F. Wong ◽  
David D. L. Bowtell ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Models

scholarly journals 15α-methoxypuupehenol Induces Antitumor Effects In Vitro and In Vivo against Human Glioblastoma and Breast Cancer Models

2017 ◽  
Vol 16 (4) ◽  
pp. 601-613 ◽  
Author(s):  
Tyvette S. Hilliard ◽  
Gabriella Miklossy ◽  
Christopher Chock ◽  
Peibin Yue ◽  
Philip Williams ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Antitumor Effects ◽  
Human Glioblastoma ◽  
Cancer Models

scholarly journals RL66 a second-generation curcumin analog has potent in vivo and in vitro anticancer activity in ER-negative breast cancer models

2012 ◽  
Vol 41 (5) ◽  
pp. 1723-1732 ◽  
Author(s):  
BABASAHEB YADAV ◽  
SEBASTIEN TAURIN ◽  
LESLEY LARSEN ◽  
RHONDA J. ROSENGREN
Keyword(s):  
Breast Cancer ◽  
Anticancer Activity ◽  
Second Generation ◽  
Curcumin Analog ◽  
Cancer Models

scholarly journals GDC-0941, a Novel Class I Selective PI3K Inhibitor, Enhances the Efficacy of Docetaxel in Human Breast Cancer Models by Increasing Cell Death In Vitro and In Vivo

2012 ◽  
Vol 18 (14) ◽  
pp. 3901-3911 ◽  
Author(s):  
Jeffrey J. Wallin ◽  
Jane Guan ◽  
Wei Wei Prior ◽  
Leslie B. Lee ◽  
Leanne Berry ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Death ◽  
Human Breast Cancer ◽  
Pi3k Inhibitor ◽  
Class I ◽  
Human Breast ◽  
Cancer Models

scholarly journals Valproic acid potentiates the anticancer activity of capecitabine in vitro and in vivo in breast cancer models via induction of thymidine phosphorylase expression

Oncotarget ◽  
2015 ◽  
Vol 7 (7) ◽  
pp. 7715-7731 ◽  
Author(s):  
Manuela Terranova-Barberio ◽  
Maria Serena Roca ◽  
Andrea Ilaria Zotti ◽  
Alessandra Leone ◽  
Francesca Bruzzese ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Valproic Acid ◽  
Anticancer Activity ◽  
Thymidine Phosphorylase ◽  
Cancer Models ◽  
Thymidine Phosphorylase Expression
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