scholarly journals Valproic acid potentiates the anticancer activity of capecitabine in vitro and in vivo in breast cancer models via induction of thymidine phosphorylase expression

Oncotarget ◽  
2015 ◽  
Vol 7 (7) ◽  
pp. 7715-7731 ◽  
Author(s):  
Manuela Terranova-Barberio ◽  
Maria Serena Roca ◽  
Andrea Ilaria Zotti ◽  
Alessandra Leone ◽  
Francesca Bruzzese ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Valproic Acid ◽  
Anticancer Activity ◽  
Thymidine Phosphorylase ◽  
Cancer Models ◽  
Thymidine Phosphorylase Expression

scholarly journals RL66 a second-generation curcumin analog has potent in vivo and in vitro anticancer activity in ER-negative breast cancer models

2012 ◽  
Vol 41 (5) ◽  
pp. 1723-1732 ◽  
Author(s):  
BABASAHEB YADAV ◽  
SEBASTIEN TAURIN ◽  
LESLEY LARSEN ◽  
RHONDA J. ROSENGREN
Keyword(s):  
Breast Cancer ◽  
Anticancer Activity ◽  
Second Generation ◽  
Curcumin Analog ◽  
Cancer Models

The truncated somatostatin receptor sst5TMD4 stimulates the production of pro-angiogenic factors in in vitro and in vivo breast cancer models

2014 ◽  
Author(s):  
Raul M Luque ◽  
Mario Duran-Prado ◽  
David Rincon-Fernandez ◽  
Marta Hergueta-Redondo ◽  
Michael D Culler ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Somatostatin Receptor ◽  
Angiogenic Factors ◽  
Cancer Models

scholarly journals Enhanced Anticancer Activity of Nanoformulation of Dasatinib against Triple-Negative Breast Cancer by Reduced Metabolic Degradation

2021 ◽  
Author(s):  
Fatemah Bahman ◽  
Valeria Pittalà ◽  
Mohamed Haider ◽  
Khaled Greish
Keyword(s):  
Breast Cancer ◽  
Anticancer Activity ◽  
Triple Negative Breast Cancer ◽  
Tyrosine Kinases ◽  
Triple Negative ◽  
Growth Factor Receptor ◽  
Initial Response ◽  
Response To Chemotherapy

Triple negative breast cancer (TNBC) is the most aggressive breast cancer accounting for around 15% of identified breast cancer cases. TNBC, by lacking estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2), is unresponsive to current targeted therapies. Existing treatment relies on chemotherapeutic treatment but, despite an initial response to chemotherapy, the inception of resistance and relapse is unfortunately common. Dasatinib is an approved second-generation inhibitor of multiple tyrosine kinases and literature data strongly support its use in the management of TNBC. However, dasatinib binds to plasma proteins and undergoes extensive metabolism through oxidation and conjugation. To protect dasatinib from fast pharmacokinetic degradation and to prolong its activity, it was encapsulated on poly(styrene-co-maleic acid) (SMA) micelles. The obtained SMA-dasatinib nanoparticles (NPs) were evaluated for their physicochemical properties, in vitro antiproliferative activity in different TNBC cell lines, and in vivo anticancer activity in a syngeneic model of breast cancer. Obtained results showed that SMA-dasatinib is more potent against 4T1 TNBC tumor growth in vivo compared to free drug. This enhanced effect was ascribed to the encapsulation of the drug protecting it from a rapid metabolism. Our finding highlights the often-overlooked value of nanoformulations in protecting its cargo from degradation. Overall, results may provide an alternative therapeutic strategy for TNBC management.

Thymic Immunosuppressive Pentapeptide (TIPP) Showed Anticancer Activity in Breast Cancer and Chronic Myeloid Leukemia Both In Vitro and In Vivo

2021 ◽  
Vol 28 ◽  
Author(s):  
Muhammad Ijaz ◽  
Muhammad Shahbaz ◽  
Wenjie Jiang ◽  
Yikang Shi ◽  
Xiuli Guo ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Chronic Myeloid Leukemia ◽  
Anticancer Activity ◽  
Myeloid Leukemia ◽  
Map Kinases ◽  
Inflammatory Responses ◽  
Tumor Xenograft ◽  
Immunohistochemistry Analysis

Aim: Being the common cause and major burden of deaths globally, timely management of cancer is crucial. Background: Thymic immunosuppressive pentapeptide (TIPP) is a novel pentapeptide originally obtained from calf thymic immunosuppressive extract. Previously, TIPP has been proved to suppress the allergic and inflammatory responses in allergic mice via blocking MAP kinases/NF-κB signaling pathways. Objective: In this study, in vitro anticancer activity of TIPP was tested on two different types of cancers using MCF-7 and K562 cell lines. Methods: Tumor xenograft models for breast cancer and chronic myeloid leukemia were designed. In vivo anticancer activity of TIPP was investigated on both cancer types. The liver and tumor tissues of the mice were preserved for immunohistochemistry analysis. Results: In vitro anticancer activity of TIPP showed significant inhibition on cell viability of both breast cancer and chronic myeloid leukemia. In vivo anticancer effect of TIPP in both types of cancer models further proved the potent anticancer nature of TIPP. Immunohistochemistry analysis assured that TIPP is a safe drug for normal organs such as the liver. Conclusion: Our present study revealed that TIPP is a potent anticancer drug and an important treatment option for various diseases. Further work is needed to test the flexible and proficient activity of the novel peptide.

scholarly journals Anticancer Activity of Andrographolide Semisynthetic Derivatives

2010 ◽  
Vol 5 (5) ◽  
pp. 1934578X1000500 ◽  
Author(s):  
Vidya Menon ◽  
Sujata Bhat
Keyword(s):  
Breast Cancer ◽  
Antitumor Activity ◽  
Myeloid Leukemia ◽  
Cancer Cell Line ◽  
Maximum Activity ◽  
In Vitro Activity ◽  
Cancer Models ◽  
In Vivo Antitumor Activity

Andrographolide 1, a diterpene lactone of Andrographis paniculata, displays in vitro and in vivo antitumor activity against breast cancer models and mouse myeloid leukemia (M1) cells. In the present study, we report the semi-synthesis of andrographolide derivatives and their in vitro activity against A549 (ATCC) (NSCL cancer) cell line. Amongst the derivatives tested, compounds 3- 5 displayed maximum activity, with IC50 values of 22-31 μg/mL.

scholarly journals Ginsenoside Rg3: Potential Molecular Targets and Therapeutic Indication in Metastatic Breast Cancer

Medicines ◽  
2019 ◽  
Vol 6 (1) ◽  
pp. 17 ◽  
Author(s):  
Maryam Nakhjavani ◽  
Jennifer E Hardingham ◽  
Helen M Palethorpe ◽  
Yoko Tomita ◽  
Eric Smith ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Treatment ◽  
Metastatic Breast ◽  
Therapeutic Agents ◽  
Ginsenoside Rg3 ◽  
Cancer Models ◽  
Anti Cancer ◽  
Ginseng Plant

Breast cancer is still one of the most prevalent cancers and a leading cause of cancer death worldwide. The key challenge with cancer treatment is the choice of the best therapeutic agents with the least possible toxicities on the patient. Recently, attention has been drawn to herbal compounds, in particular ginsenosides, extracted from the root of the Ginseng plant. In various studies, significant anti-cancer properties of ginsenosides have been reported in different cancers. The mode of action of ginsenoside Rg3 (Rg3) in in vitro and in vivo breast cancer models and its value as an anti-cancer treatment for breast cancer will be reviewed.

scholarly journals The Antioxidant N-Acetylcysteine Prevents HIF-1 Stabilization under Hypoxia In Vitro but Does Not Affect Tumorigenesis in Multiple Breast Cancer Models In Vivo

PLoS ONE ◽  
2013 ◽  
Vol 8 (6) ◽  
pp. e66388 ◽  
Author(s):  
Jaclyn Sceneay ◽  
Mira C. P. Liu ◽  
Anna Chen ◽  
Christina S. F. Wong ◽  
David D. L. Bowtell ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Models

Phosphodiesterase inhibitor, pentoxifylline enhances anticancer activity of histone deacetylase inhibitor, MS-275 in human breast cancer in vitro and in vivo

2015 ◽  
Vol 764 ◽  
pp. 508-519 ◽  
Author(s):  
Saranya Nidhyanandan ◽  
Thippeswamy S. Boreddy ◽  
Kothapalli B. Chandrasekhar ◽  
Neetinkumar D. Reddy ◽  
Nagaraj M. Kulkarni ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Anticancer Activity ◽  
Histone Deacetylase ◽  
Histone Deacetylase Inhibitor ◽  
Human Breast Cancer ◽  
Phosphodiesterase Inhibitor ◽  
Human Breast ◽  
Deacetylase Inhibitor

Anticancer activity of litchi fruit pericarp extract against human breast cancer in vitro and in vivo

2006 ◽  
Vol 215 (2) ◽  
pp. 168-178 ◽  
Author(s):  
X WANG ◽  
S YUAN ◽  
J WANG ◽  
P LIN ◽  
G LIU ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Anticancer Activity ◽  
Human Breast Cancer ◽  
Human Breast ◽  
Fruit Pericarp ◽  
Litchi Fruit
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