Morphological Diagnosis by Bone Marrow Aspirate of Toxoplasmosis Infection in an HIV-Positive Patient

Background: The World Health Organization (WHO) announced the SARS-COV-2 disease pandemic on March 9, 2020.With the advent of this disease, another health burden was added to about 37.9 million people in the world who are infected with HIV and are suffering from various diseases. These people may be at serious risk of covid-19. Information about the effects of Covid-19 on people living with HIV, is limited. Case presentation: We reported a 61-year-old man who was a known case of HIV from 6 years ago that was being treated with HAART (highly active antiretroviral therapy). He also had a history of Hodgkin’s lymphoma from 4 years ago who underwent autologous bone marrow transplantation (BMT) 2 weeks before given referral to our hospital. He complained of weakness, anorexia, and fever. RT-PCR for SARS-COV-2-RNA was positive in his nasopharyngeal and oropharyngeal swab. He was diagnosed with COVID-19 infection and treated with atazanavir. After one week, the patient discharged in a good general state. Conclusion: To the best of our knowledge, it is the first report of COVID-19 infection in an HIV positive patient after BMT in Iran. Despite his immunodeficiency, COVID-19 disease had mild manifestations and he had a good prognosis. We hope that our report and that of others can remain promising to doctors and HIV patients cross fingers for COVID-19 recovery.

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Atypical mycobacteria diagnosed by bone marrow biopsy in an HIV-positive patient

Annals of Hematology ◽

10.1007/s00277-019-03880-y ◽

2019 ◽

Vol 99 (1) ◽

pp. 183-184

Author(s):

Magda Zanelli ◽

Maurizio Zizzo ◽

Giulia Cerrone ◽

Linda Ricci ◽

Giovanni Martino ◽

...

Keyword(s):

Bone Marrow ◽

Bone Marrow Biopsy ◽

Positive Patient ◽

Atypical Mycobacteria ◽

Hiv Positive

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Mycobacterium genavenseinvading the bone marrow in a HIV-positive patient

Clinical Case Reports ◽

10.1002/ccr3.961 ◽

2017 ◽

Vol 5 (6) ◽

pp. 1043-1045

Author(s):

Christianne Bourlon ◽

Cesar Vargas-Serafín ◽

Xavier López-Karpovitch

Keyword(s):

Bone Marrow ◽

Positive Patient ◽

Hiv Positive

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EBV-positive large B-cell lymphoma with an unusual intravascular presentation and associated haemophagocytic syndrome in an HIV-positive patient: report of a case expanding the spectrum of EBV-positive immunodeficiency-associated lymphoproliferative disorders

Virchows Archiv ◽

10.1007/s00428-021-03142-1 ◽

2021 ◽

Author(s):

Luis Veloza ◽

Chun-Yi Tsai ◽

Bettina Bisig ◽

Olivier Pantet ◽

Lorenzo Alberio ◽

...

Keyword(s):

Bone Marrow ◽

Lymph Nodes ◽

B Cell ◽

Cell Lymphoma ◽

Fatal Outcome ◽

B Cell Lymphoma ◽

Positive Patient ◽

Hiv Positive ◽

Large B Cell Lymphoma ◽

Large B Cell

AbstractIntravascular large B-cell lymphoma is a rare and aggressive EBV-negative large B-cell lymphoma with a dismal outcome. Here, we describe the case of a 76-year-old HIV-positive patient with an acute presentation of systemic symptoms and rapidly fatal outcome. Autopsy revealed a disseminated large B-cell lymphoma with an intravascular distribution involving the liver, lymph nodes, spleen, and bone marrow and associated to fibrin thrombi in hepatic capillary haemangiomas. The neoplastic B cells (CD79a + / − , CD20 + / − , CD30 + , MUM1 + , PD-L1 +) showed a Hodgkin and Reed-Sternberg-like morphology and were EBV-positive with a latency type II (LMP1 + , EBNA2-). Haemophagocytosis was documented in the bone marrow and lymph nodes. This case illustrates the diagnostic challenges of large B-cell lymphoma with intravascular presentation. We found only five other cases of EBV-positive large B-cell lymphoma with an intravascular presentation in the literature, three of which had an underlying immunodeficiency adding to the broad spectrum of EBV-associated lymphoma in the setting of immunosuppression.

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DECREASED CD10 EXPRESSION IN THE BONE MARROW NEUTROPHILS OF HIV POSITIVE PATIENTS

Mediterranean Journal of Hematology and Infectious Diseases ◽

10.4084/mjhid.2010.032 ◽

2010 ◽

Vol 2 (3) ◽

pp. e2010032 ◽

Cited By ~ 2

Author(s):

Annemarie Van de Vyver ◽

Adele Visser

Keyword(s):

Bone Marrow ◽

Flow Cytometry ◽

Marked Reduction ◽

Bone Marrow Aspirate ◽

Hiv Positive ◽

Morphological Abnormality ◽

Cd10 Expression ◽

Haemopoietic Cells ◽

Hiv 1 ◽

Qualitative Changes

Background: HIV-1 infection is associated with various quantitative and qualitative changes in haemopoietic cells. Clear distinction between primary myelodysplastic syndrome (MDS) and secondary dysplasia may not always be possible. Adjunctive analyses used in the diagnosis of MDS include cytogenetics and flow cytometry (FCM). Much focus has been placed on establishing FCM guidelines aiding in the diagnosis of MDS, and to distinguish this condition from secondary dysplastic changes. One of the parameters often cited is the CD10 expression on the granulocyte population, as this marker denotes granulocytic maturation. Aims: To determine the expression level of CD10 on granulocytes in HIV positive patients. Methods: In total, 117 HIV-1 positive and 29 HIV-1 negative patients were included in this study. Bone marrow aspirate samples were evaluated in terms of morphological abnormality as well as CD10 expression on the granulocytic population. Results: The average CD10 expression among the HIV-1 positive patients were markedly reduced, at 18.4%, and 113 patients (96.6%) of these patients had expression levels below 50%. Discussion: Disease conditions causing secondary dysplasia, especially HIV-1 infection, is associated with a marked reduction in CD10 expression on the granulocyte population independent from the presence of myelodysplastic features. This marker is therefore of doubtful significance as a diagnostic tool in distinguishing between primary and secondary dysplasia.

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