The object of research is the deformation of the deep layers and the Moho surface the East European platform is identified on the basis of structural analysis thickness of the deep layers of the Earth's crust and of the Moho surface. Initial data - geological and geophysical materials of the lithosphere of the East European platform, the thickness of the lower, middle, and upper layers of the Earth's crust, and the newest structures. Research methods are structural-geodynamic and comparative- tectonic, which allow us to assess the spatial and temporal variability of deep and near-surface deformations. Results. Active centers and relatively passive deformations associated are combined into geodynamic regions, the boundaries of which are zones of structural disagreement. Geodynamic regions are divided into main and secondary. The first is expressed by stable and long-term development, the second - is shown in separate layers of the Earth’s crust. It is established that the protrusions of the mantle lithosphere cause a reduction in the thickness of the layers of the Earth's crust and the formation of the newest trough. The sinking of the mantle lithosphere affects the increase in power in the lower and upper layers and the formation of the newest uplifts. The intermediate layer is considered as a compensation layer. Thinning and thick parts of the individual layers lead to the formation of the newest local trough and uplifts. Thus, the conformal and disconform correlation of deformations of deep layers and the newest structures is a characteristic property of the structure of the platform lithosphere. The sources of deep deformations are extra-platform regional areas of recent tectogenesis and intraplatform local active centers - protrusions and trough of the mantle lithosphere, abnormal thickening and thinning of the Earth's crust layers.