Relationship between QTc Dispersion and Adenosine Triphosphate Stress Thallium-201/123I-BMIPP Dual SPECT Imaging for Evaluating the Salvage Effect on Ischemic Myocardium

SummaryIntestinal mucosa heparin (IMH) and beef lung heparin (BLH) were infused into dogs subjected to myocardial ischemia by intermittent coronary artery occlusions. The IMH was from a mixture of beef, sheep, and pig intestinal mucosa. Initial control occlusion and recovery was followed by a second occlusion with 60,000 units of IMH or BLH added. Electrocardiographic S-T segment elevations (ST) were measured acutely. There were no significant differences in ST in non-ischemic myocardium before occlusions or with occlusions. In ischemic myocardium, IMH significantly lowered control ST 84% in amount (t = 6.1 p <0.00005), and 76% in number (t = 11.6 p <0.00001). BLH lowered control ST a significant, lesser, 36% in amount (t = 3.6 p <0.008), and 35% in number (t = 3.2 p <0.01). The difference between IMH and BLH in ischemic myocardium was a significant 48% in amount (t = 4.0 p <0.0007), and 41% in number (t = 2.0 p <0.06). Myocardial adenosine triphosphate (ATP) levels were assayed after 90 min. ATP levels were 31% higher in both ischemic and non-ischemic myocardium in IMH-treated dogs than in BLH- treated. It was concluded that IMH and BLH are functionally different, and IMH was significantly more effective.

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Intravenous Dipyridamole Thallium-201 SPECT Imaging in Patients with Left Bundle Branch Block

Clinical Nuclear Medicine ◽

10.1097/00003072-199006000-00008 ◽

1990 ◽

Vol 15 (6) ◽

pp. 401-407 ◽

Cited By ~ 37

Author(s):

JOHN F. ROCKETT ◽

W CHADWICK WOOD ◽

MOHAMMED MOINUDDIN ◽

VIVIAN LOVELESS ◽

BEVERLY PARRISH

Keyword(s):

Left Bundle Branch Block ◽

Thallium 201 ◽

Spect Imaging ◽

Bundle Branch Block ◽

Dipyridamole Thallium

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Quantitative Analysis of Echocardiographic Cine-Loops Using a 2D-Strain Algorithm in Correlation with Thallium-201 SPECT Imaging

Ultrasound in Medicine & Biology ◽

10.1016/j.ultrasmedbio.2008.03.021 ◽

2008 ◽

Vol 34 (11) ◽

pp. 1732-1740

Author(s):

Aaron Miller ◽

Pierre Chouraqui ◽

Gil Zwirn ◽

Micha S. Feinberg ◽

Solange Akselrod

Keyword(s):

Quantitative Analysis ◽

Thallium 201 ◽

Spect Imaging ◽

2D Strain

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Exercise Echocardiographic Correlates of Transient Dilatation of the Left Ventricular Cavity on Exercise Thallium-201 SPECT Imaging

CHEST Journal ◽

10.1378/chest.106.6.1725 ◽

1994 ◽

Vol 106 (6) ◽

pp. 1725-1729 ◽

Cited By ~ 16

Author(s):

Andrew Van Tosh ◽

Susan Hecht ◽

Marvin Berger ◽

Roberto Roberti ◽

Evangeline Luna ◽

...

Keyword(s):

Left Ventricular ◽

Thallium 201 ◽

Spect Imaging ◽

Left Ventricular Cavity ◽

Ventricular Cavity

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Abstract 19973: Dynamic Thallium-201 SPECT/CT Provides Quantitative Index of Myocardial Flow and Viability: Validation in Porcine Post-Myocardial Infarction Model

Circulation ◽

10.1161/circ.130.suppl_2.19973 ◽

2014 ◽

Vol 130 (suppl_2) ◽

Author(s):

Stephanie L Thorn ◽

Mitchel R Stacy ◽

Alda Bregasi ◽

Jin C Paeng ◽

Vahid A Tavakoli ◽

...

Keyword(s):

Myocardial Infarction ◽

Compartment Model ◽

Ct Imaging ◽

Thallium 201 ◽

Spect Imaging ◽

Wall Thickening ◽

List Mode ◽

Quantitative Index ◽

Contrast Ct ◽

Myocardial Flow

Introduction: Thallium-201 (Tl-201) SPECT imaging is routinely used to evaluate relative myocardial perfusion and/or viability. In this study, we have evaluated Tl-201 kinetics in a porcine model of myocardial infarction (MI) with dynamic imaging on a hybrid SPECT/CT system. Methods: Tl-201 SPECT and contrast CT imaging were performed on hybrid SPECT/64-slice CT (GE Discovery NM/CT 570c) in Yorkshire pigs (n=5) one week following a 90 min balloon occlusion of the LAD below the first diagonal branch. Tl-201 (83-158 MBq) was injected after the initiation of a 900s list-mode acquisition. The list-mode data was reconstructed with MLEM using 30 iterations creating 23 frames (12 x 10s; 6 x 30s; 5 x 120s). Reconstructed dynamic SPECT data was analyzed using FlowquantTM semi-automated analysis software with a 1-compartment model. K1 (index of flow) and k2 (index of viability) were assessed within a 17-segment model of the left ventricle. Four segments within the central infarcted LAD territory were compared to six segments of the contralateral inferolateral wall. The same segments were analyzed for wall thickening from ECG-gated contrast CT scans using centerline approach (GE AW Cardiac Function Xpress). Results: K1 was significantly decreased in the MI vs contralateral normal regions (0.52 ± 0.17 vs 0.61 ± 0.16 ml/min/g, p<0.02). K2 an index of tissue viability was significantly increased in the MI region (0.42 ± 0.19 vs 0.32 ± 0.12 /min, p<0.04), reflecting accelerated Tl-201 washout in MI. Wall thickening in the same MI region was significantly decreased (0.33 ± 1.5 mm vs 3.3 ± 1.9 mm, p<0.005). Conclusions: Dynamic Tl-201 SPECT/CT imaging provides a quantitative index of both myocardial flow and viability using a 1-compartment model. This preliminary pre-clinical demonstrates the potential for dynamic Tl-201 SPECT imaging to quantify myocardial viability early post-MI.

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