Influence of Germanium on Some Properties of Calcium Phosphate Coatings on Titanium Implants

2019 ◽  
Keyword(s):  
Calcium Phosphate ◽  
Titanium Implants ◽  
Phosphate Coatings ◽  
Calcium Phosphate Coatings

scholarly journals Hybrid Calcium Phosphate Coatings for Titanium Implants

2017 ◽  
Vol 789 ◽  
pp. 012025
Author(s):  
E. Kharapudchenko ◽  
V. Ignatov ◽  
V. Ivanov ◽  
S. Tverdokhlebov
Keyword(s):  
Calcium Phosphate ◽  
Titanium Implants ◽  
Phosphate Coatings ◽  
Calcium Phosphate Coatings

Osseointegration of Calcium Phosphate Nanofilms on Titanium Alloy Implants

2007 ◽  
Vol 361-363 ◽  
pp. 645-648
Author(s):  
M.D. Paz ◽  
Stefano Chiussi ◽  
Pio González ◽  
Julia Serra ◽  
Betty León ◽  
...  
Keyword(s):  
Electron Microscopy ◽  
Titanium Alloy ◽  
Calcium Phosphate ◽  
Bone Regeneration ◽  
Bone Growth ◽  
Pulsed Laser ◽  
Titanium Implants ◽  
Optical Methods ◽  
Phosphate Coatings ◽  
Calcium Phosphate Coatings

In the present work two different hydroxyapatite nanofilms (50 and 100 nm thick) have been successfully deposited on titanium implants that were previously laser macrostructured in order to assess the influence of the thickness of nanometric calcium phosphate coatings on the osseointegration. Cylindrical implants were tested in a sheep tibia model together with titanium alloy controls achieving very good osseointegration results. Laser macrostructured titanium alloy implants have shown improved bone regeneration when coated with nanometric films of carbonated HA. The pulsed laser deposited nanofilm has promoted bone in-growth deep into the laser ablated craters. There were no significant differences between the two coating thicknesses, neither when assessed with electron microscopy or classical optical methods. This result suggests that the 50 nm coating is as effective as the 100 nm one, therefore implying that the thickness limit for such a bioactive layer to stimulate bone growth may be even further below.

Study of Titanium Surface Topography Influence on Biomimetic Coating Deposition

2012 ◽  
Vol 727-728 ◽  
pp. 1622-1627
Author(s):  
Roseli Marins Balestra ◽  
Alexandre Antunes Ribeiro ◽  
M.C. Andrade ◽  
Luiz Carlos Pereira ◽  
Marize Varella
Keyword(s):  
Powder Metallurgy ◽  
Calcium Phosphate ◽  
Calcium Phosphates ◽  
Titanium Implants ◽  
Precipitation Method ◽  
Phosphate Coatings ◽  
Biomimetic Coating ◽  
Simplified Solution ◽  
Calcium Phosphate Coatings ◽  
Titanium Substrates

Studies show that calcium phosphate coatings on titanium implants improve osseointegration at the implant-bone interface, due to the mineral biocompatibility. Titanium implants can be coated with calcium phosphates by a biomimetic precipitation method. This work studied a biomimetic method under a simplified solution with calcium and phosphorus ions. As substrates, commercially dense titanium sheet and macroporous titanium samples produced by powder metallurgy were used, both ASTM F67 grade 2. The substrates were submitted to chemical and heat treatment and then immersed in the solution for 10 days. Samples characterization was performed by Optical Microscopy (OM), Scanning Electron Microscopy/Energy Dispersive Spectroscopy (SEM/EDS), low angle X-ray Diffractometry (XRD) and Fourier Transform Infrared Spectroscopy (FTIR). Powder metallurgy successfully produced macroporous titanium substrates. Calcium phosphate coatings were deposited on both substrates, confirmed by FTIR bands. Such results indicated the potential of this methodology for calcium phosphate coatings on titanium substrates.

The effect of calcium phosphate biodegradable coatings of titanium implants on cell differentiation and apoptosis in rat bone tissue after experimental fracture

2020 ◽  
pp. 1-10
Author(s):  
Sergei Kalinichenko ◽  
Natalya Matveeva ◽  
Roman Kostiv ◽  
Sergey Edranov
Keyword(s):  
Stem Cells ◽  
Calcium Phosphate ◽  
Caspase 3 ◽  
Titanium Implants ◽  
Surrounding Tissue ◽  
Spatial Density ◽  
Experimental Fracture ◽  
Phosphate Coatings ◽  
Calcium Phosphate Coatings ◽  
Haversian Canals

BACKGROUND: The effectiveness of bone repair is determined by the balance of proliferative and destructive factors in the fracture union site. It can be enhanced by using various nanostructured materials possessing osteoinductive properties, in particular titanium implants with biodegradable calcium phosphate coatings. The effects of these coatings on the state of stem cells, their differentiation and distribution in the repair zone is unknown. OBJECTIVE : To study the dynamics of proliferation, differentiation, and apoptosis of stem cells after experimental fracture followed by implantation of titanium implants with calcium phosphate coatings. METHODS: The localization of proliferation (PCNA) and differentiation (CD44 and osteocalcin) factors and apoptotic molecules (MDM2, p53, caspase-3) was studied in a rat femoral fracture model with implant placement. Titanium implant screws with bioactive calcium phosphate and hydroxyapatite coatings formed by plasma electrolytic oxidation were used in the study. Experimental rats were arranged into three groups (15 animals per group): control group; rats implanted with uncoated implants; and rats implanted with coated implants. Control rats were subject to a similar fracture as experimental ones and were allowed to heal conservatively. Rats from all groups were sampled on days 7, 14, and 30 after injury. RESULTS: Low-differentiated PCNA-, osteocalcin-, and CD44-immunopositive cells were localized around the implant in the inner layer of the periosteum, layer of outer circumferential lamellae, and connective tissue lining of haversian canals. The spatial density of cells expressing the above proliferation and differentiation factors, as well as that of MDM2-immunoreactive cells, increased on day 7 and decreased by day 30 after injury. The spatial density of apoptotic cells reached the maximum on day 14 after injury. They were mainly found in the inner layer of the periosteum and outer circumferential lamellae. p53- and caspase-3-positive cells occurred on the surface of the concentric lamellae surrounding haversian canals and under the periosteum. Their spatial density decreased by day 30 after injury. CONCLUSIONS: Calcium phosphate coatings stimulate cell proliferation at early stages of fracture restoration and apoptotic cell death at later stages. Coating components may provide positional information guiding the differentiation of mesenchymal stromal cells. A change in the activity of apoptotic factors, osteocalcin, and CD44 is caused by gene induction in response to the diffusion of calcium phosphate compounds from coating to surrounding tissue.

Proteins Modulate the Properties of Biomimetic Calcium Phosphate Coatings on Titanium Implants

2001 ◽  
Vol 218-220 ◽  
pp. 157-160
Author(s):  
Yi Liu ◽  
M. Stigter ◽  
K. de Groot ◽  
Pierre Layrolle
Keyword(s):  
Calcium Phosphate ◽  
Titanium Implants ◽  
Phosphate Coatings ◽  
Calcium Phosphate Coatings

Principal Physics of Oblique Sputtering of Calcium Phosphate Coatings Using RF-Magnetron Discharge Plasma

2021 ◽  
Vol 63 (11) ◽  
pp. 1891-1897
Author(s):  
K. A. Prosolov ◽  
O. A. Belyavskaya ◽  
V. V. Lastovka ◽  
M. V. Chaikina ◽  
Yu. P. Sharkeev
Keyword(s):  
Calcium Phosphate ◽  
Discharge Plasma ◽  
Magnetron Discharge ◽  
Phosphate Coatings ◽  
Calcium Phosphate Coatings
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