Tick-borne encephalitis virus (TBEV) exists in natural foci, which are areas where TBEV is circulating among its vectors (ticks of different species and genera) and reservoir hosts (usually rodents and small mammals).
Based on phylogenetic studies, four TBEV subtypes (Far-Eastern, Siberian, European, Baikalian) and two putative subtypes (Himalayan and “178-79” group) are known. Within each subtype, some genetic lineages are described.
The European subtype (TBEV-EU) (formerly known also as the “Western subtype”) of TBEV is prevalent in
Europe, but it was also isolated in Western and Eastern Siberia in Russia and South Korea.
The Far-Eastern subtype (TBEV-FE) was preferably found in the territory of the far-eastern part of Eurasia, but some strains were isolated in other regions of Eurasia.
The Siberian (TBEV-SIB) subtype is the most common and has been found in almost all TBEV habitat areas.
The Baikalian subtype is prevalent around Lake Baikal and was isolated several times from ticks and rodents.
In addition to the four TBEV subtypes, one single isolate of TBEV (178-79) and two genetic sequences (Himalayan) supposed to be new TBEV subtypes were described in Eastern Siberia and China.
The data on TBEV seroprevalence in humans and animals can serve as an indication for the presence or absence of TBEV in studied area.
