Fluorescent Mueller-matrix polarimetry of biological tissues in differentiation of benign and malignant tumors

At the present time hyperthermia is recognized as one of the most promising methods in the combined treatment of malignant tumors. Nevertheless, for the most of existing methods for heating of tumor tissues it is rather difficult to realize the exact localization of heat exposure. The aim of this study is to compare two types of implants for intraoperative local tumor bed hyperthermia carried out using induction heating in an alternating magnetic field of the sub-MHz range. Composite implants of the first type are created on the base of a self-curing plastic mass mixed with electrically conductive ferromagnetic particles. The second type of implant is a hollow object with thin walls that follows the shape of the tumor. Implants of this type are filled with a liquid metal non-magnetic alloy with melting point below room temperature. The model implants were heated in a self-designed inductor with a short cylindrical coil 35 cm in diameter. Biological tissues were modeled using an ultrasound gel. Experimental results show that both types of implants were heated in an external alternating magnetic field with a frequency of 90 kHz and an amplitude not exceeding 4 kA/m up to temperatures that allow both traditional hyperthermia (tissue heating to 41-45 °C) and thermal ablation therapy (tissue heating to temperatures above 50 °C). Good agreement between the experimental data and model numerical calculations was obtained.

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Study of the spatial scale stability of Mueller matrix parameters for textural characterization of biological tissues

Journal of Biophotonics ◽

10.1002/jbio.202100269 ◽

2021 ◽

Author(s):

Yongtai Chen ◽

Jinkui Chu ◽

William C. Tang ◽

Ran Zhang ◽

Mingyu Zhao ◽

...

Keyword(s):

Spatial Scale ◽

Biological Tissues ◽

Mueller Matrix ◽

Textural Characterization

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Characterizing the microstructures of biological tissues using Mueller matrix and transformed polarization parameters

Biomedical Optics Express ◽

10.1364/boe.5.004223 ◽

2014 ◽

Vol 5 (12) ◽

pp. 4223 ◽

Cited By ~ 96

Author(s):

Minghao Sun ◽

Honghui He ◽

Nan Zeng ◽

E Du ◽

Yihong Guo ◽

...

Keyword(s):

Biological Tissues ◽

Mueller Matrix

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Mueller-matrix differentiation of necrotic changes in polycrystalline structure of partially depolarizing layers of biological tissues

Advanced Topics in Optoelectronics, Microelectronics and Nanotechnologies X ◽

10.1117/12.2571205 ◽

2020 ◽

Author(s):

Ivan Savka ◽

Yuriy Tomka ◽

Iryna Soltys ◽

Olexander V. Dubolazov ◽

Olexander Olar ◽

...

Keyword(s):

Biological Tissues ◽

Mueller Matrix ◽

Polycrystalline Structure

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Complementary analysis of Mueller-matrix images of optically anisotropic highly scattering biological tissues

Journal of the European Optical Society Rapid Publications ◽

10.1186/s41476-018-0085-9 ◽

2018 ◽

Vol 14 (1) ◽

Cited By ~ 13

Author(s):

Mariia Borovkova ◽

Motahareh Peyvasteh ◽

Olexander Dubolazov ◽

Yurii Ushenko ◽

Volodymyr Ushenko ◽

...

Keyword(s):

Biological Tissues ◽

Mueller Matrix ◽

Complementary Analysis

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QUANTITATIVE MUELLER MATRIX POLARIMETRY TECHNIQUES FOR BIOLOGICAL TISSUES

Journal of Innovative Optical Health Sciences ◽

10.1142/s1793545812500174 ◽

2012 ◽

Vol 05 (03) ◽

pp. 1250017 ◽

Cited By ~ 7

Author(s):

HONGHUI HE ◽

NAN ZENG ◽

DONGZHI LI ◽

RAN LIAO ◽

HUI MA

Keyword(s):

Early Stage ◽

Structural Characteristics ◽

Potential Method ◽

Biological Tissues ◽

Anisotropic Scattering ◽

Mueller Matrix ◽

Matrix Transformation ◽

Scattering Media ◽

Tissue Samples ◽

The Media

We propose and conduct both the rotating linear polarization imaging (RLPI) and Mueller matrix transformation (MMT) measurements of different biological tissue samples, and testify the capability of the Mueller matrix polarimetry for the anisotropic scattering media. The independent parameters extracted from the RLPI and MMT techniques are compared and analyzed. The tissue experimental results show that the parameters are closely related to the structural characteristics of the turbid scattering media, including the sizes of the scatterers, the angular distribution and order of alignment of the fibers. The results and conclusions in this paper may provide a potential method for the detection of precancerous and early stage cancerous tissues. Also, such studies represent the Mueller matrix transformation procedure which results in a set of parameters linking up the Mueller matrix elements to the structural and optical properties of the media.

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