QUANTITATIVE MUELLER MATRIX POLARIMETRY TECHNIQUES FOR BIOLOGICAL TISSUES

2012 ◽  
Vol 05 (03) ◽  
pp. 1250017 ◽  
Author(s):  
HONGHUI HE ◽  
NAN ZENG ◽  
DONGZHI LI ◽  
RAN LIAO ◽  
HUI MA
Keyword(s):  
Early Stage ◽  
Structural Characteristics ◽  
Potential Method ◽  
Biological Tissues ◽  
Anisotropic Scattering ◽  
Mueller Matrix ◽  
Matrix Transformation ◽  
Scattering Media ◽  
Tissue Samples ◽  
The Media

We propose and conduct both the rotating linear polarization imaging (RLPI) and Mueller matrix transformation (MMT) measurements of different biological tissue samples, and testify the capability of the Mueller matrix polarimetry for the anisotropic scattering media. The independent parameters extracted from the RLPI and MMT techniques are compared and analyzed. The tissue experimental results show that the parameters are closely related to the structural characteristics of the turbid scattering media, including the sizes of the scatterers, the angular distribution and order of alignment of the fibers. The results and conclusions in this paper may provide a potential method for the detection of precancerous and early stage cancerous tissues. Also, such studies represent the Mueller matrix transformation procedure which results in a set of parameters linking up the Mueller matrix elements to the structural and optical properties of the media.

A possible quantitative Mueller matrix transformation technique for anisotropic scattering media/Eine mögliche quantitative Müller-Matrix-Transformations-Technik für anisotrope streuende Medien

2013 ◽  
Vol 2 (2) ◽  
Author(s):  
Honghui He ◽  
Nan Zeng ◽  
E Du ◽  
Yihong Guo ◽  
Dongzhi Li ◽  
...  
Keyword(s):  
Biological Tissues ◽  
Anisotropic Scattering ◽  
Mueller Matrix ◽  
Polar Coordinates ◽  
Matrix Transformation ◽  
Matrix Transformations ◽  
Matrix Elements ◽  
Scattering Media ◽  
Structural And Optical Properties ◽  
Analytical Functions

AbstractBy conducting both the experiments on samples containing well-aligned fibers and Monte Carlo simulations based on the sphere cylinder scattering model (SCSM), we present a Mueller matrix transformation (MMT) method for quantitatively characterizing the properties of anisotropic scattering media. We obtained a set of parameters by fitting the Mueller matrix elements to trigonometric curves in polar coordinates. These new parameters can be expressed as analytical functions of the Mueller matrix elements and display simple relationships to the structural and optical properties of the anisotropic scattering media, such as the anisotropy, the direction of the fibers, and the sizes of the scatterers. Experimental results on biological tissues show that these new parameters can be used in biomedical research. However, further studies are still necessary to correlate the MMT parameters to pathological features.

scholarly journals Comparative Study of Modified Mueller Matrix Transformation and Polar Decomposition Parameters for Transmission and Backscattering Tissue Polarimetries

2021 ◽  
Vol 11 (21) ◽  
pp. 10416
Author(s):  
Binguo Chen ◽  
Yuxiang Lan ◽  
Haoyu Zhai ◽  
Liangyu Deng ◽  
Honghui He ◽  
...  
Keyword(s):  
Optical Properties ◽  
Comparative Analysis ◽  
Comparative Study ◽  
Polar Decomposition ◽  
Mueller Matrix ◽  
Clinical Applications ◽  
Matrix Transformation ◽  
Tissue Samples ◽  
Axis Orientation ◽  
Transmission Imaging

Mueller matrix polarimetry is widely used in biomedical studies and applications, for it can provide abundant microstructural information about tissues. Recently, several methods have been proposed to decompose the Mueller matrix into groups of parameters related to specific optical properties which can be used to reveal the microstructural information of tissue samples more clearly and quantitatively. In this study, we thoroughly compare the differences among the parameters derived from the Mueller matrix polar decomposition (MMPD) and Mueller matrix transformation (MMT), which are two popular methods in tissue polarimetry studies and applications, while applying them on different tissue samples for both backscattering and transmission imaging. Based on the Mueller matrix data obtained using the setups, we carry out a comparative analysis of the parameters derived from both methods representing the same polarization properties, namely depolarization, linear retardance, fast axis orientation and diattenuation. IN particular, we propose several modified MMT parameters, whose abilities are also analyzed for revealing the information about the specific type of tissue samples. The results presented in this study evaluate the applicability of the original and modified MMT parameters, then give the suggestions for appropriate parameter selection in tissue polarimetry, which can be helpful for future biomedical and clinical applications.

Reducing the orientation influence of Mueller matrix measurements for anisotropic scattering media

2014 ◽  
Author(s):  
Minghao Sun ◽  
Honghui He ◽  
Nan Zeng ◽  
E. Du ◽  
Yonghong He ◽  
...  
Keyword(s):  
Anisotropic Scattering ◽  
Mueller Matrix ◽  
Scattering Media

scholarly journals CHARACTERISTIC FEATURES OF MUELLER MATRIX PATTERNS FOR POLARIZATION SCATTERING MODEL OF BIOLOGICAL TISSUES

2014 ◽  
Vol 07 (01) ◽  
pp. 1350028 ◽  
Author(s):  
E DU ◽  
HONGHUI HE ◽  
NAN ZENG ◽  
CELONG LIU ◽  
YIHONG GUO ◽  
...  
Keyword(s):  
Optical Properties ◽  
Optical Activity ◽  
Surrounding Medium ◽  
Biological Tissues ◽  
Anisotropic Scattering ◽  
Mueller Matrix ◽  
Polarization Imaging ◽  
Activity Effect ◽  
Characteristic Features ◽  
Solid Spheres

We developed a model to describe polarized photon scattering in biological tissues. In this model, tissues are simplified to a mixture of scatterers and surrounding medium. There are two types of scatterers in the model: solid spheres and infinitely long solid cylinders. Variables related to the scatterers include: the densities and sizes of the spheres and cylinders, the orientation and angular distribution of cylinders. Variables related to the surrounding medium include: the refractive index, absorption coefficient and birefringence. In this paper, as a development we introduce an optical activity effect to the model. By comparing experiments and Monte Carlo simulations, we analyze the backscattering Mueller matrix patterns of several tissue-like media, and summarize the different effects coming from anisotropic scattering and optical properties. In addition, we propose a possible method to extract the optical activity values for tissues. Both the experimental and simulated results show that, by analyzing the Mueller matrix patterns, the microstructure and optical properties of the medium can be obtained. The characteristic features of Mueller matrix patterns are potentially powerful tools for studying the contrast mechanisms of polarization imaging for medical diagnosis.

scholarly journals Quantitative Analysis of 4 × 4 Mueller Matrix Transformation Parameters for Biomedical Imaging

Photonics ◽  
2019 ◽  
Vol 6 (1) ◽  
pp. 34 ◽  
Author(s):  
Wei Sheng ◽  
Weipeng Li ◽  
Ji Qi ◽  
Teng Liu ◽  
Honghui He ◽  
...  
Keyword(s):  
Polar Decomposition ◽  
Mueller Matrix ◽  
Matrix Transformation ◽  
Matrix Elements ◽  
Tissue Slices ◽  
Tissue Samples ◽  
Microscopic Imaging ◽  
Imaging Results ◽  
Transformation Parameters ◽  
Bulk Tissue

Mueller matrix polarimetry is a potentially powerful technique for obtaining microstructural information of biomedical specimens. Thus, it has found increasing application in both backscattering imaging of bulk tissue samples and transmission microscopic imaging of thin tissue slices. Recently, we proposed a technique to transform the 4 × 4 Mueller matrix elements into a group of parameters, which have explicit associations with specific microstructural features of samples. In this paper, we thoroughly analyze the relationships between the Mueller matrix transformation parameters and the characteristic microstructures of tissues by using experimental phantoms and Monte Carlo simulations based on different tissue mimicking models. We also adopt quantitative evaluation indicators to compare the Mueller matrix transformation parameters with the Mueller matrix polar decomposition parameters. The preliminary imaging results of bulk porcine colon tissues and thin human pathological tissue slices demonstrate the potential of Mueller matrix transformation parameters as biomedical diagnostic indicators. Also, this study provides quantitative criteria for parameter selection in biomedical Mueller matrix imaging.

AUTISM IN THE DISCOURSE OF THE RUSSIAN MASS MEDIA: CONSTRUCTING OF THE IMAGE OF A HUMAN WITH ASD

2020 ◽  
pp. 37-43
Author(s):  
Saveleva Zh.V.
Keyword(s):  
Mass Media ◽  
Early Stage ◽  
Autism Spectrum ◽  
Media Discourse ◽  
Adults With Autism ◽  
Video Clips ◽  
The Media ◽  
Inner World ◽  
Spectrum Disorders ◽  
The Mass Media

The prevalence of autism is growing, the problems of stigmatization and discrimination of people with autism spectrum disorders in society are exacerbating. The mass media play an important role in enlightening and reducing stigmatizing effects, in connection with which the goal was formulated to study the construction of images of a person with ASD in the mass media by the method of qualitative and discourse analysis of video clips from the federal channel. According to the results of the study, it can be argued that the range of characteristics used to describe people with autism in media discourse is diverse, but in retrospect, dominant interpretation models can be identified. At an early stage, the prevailing image of a person with ASD was deprived of the quality’s characteristic of normotypical people who do not want to leave their world. People diagnosed with autism were referred to as the intolerant category of "autistic". Since 2013, there has been a discursive turn, within which the category “autist” is replaced by tolerant speech patterns, adults with autism get into the lens of the media, the topic of uncommunicability as a property of a person with autism is replaced by the intention of the lack of opportunities to communicate, one of the reasons for which is social exclusion. In television stories of recent years, the mass media are actively constructing the image of a person with autism spectrum disorder through his inner world, through the advantages that a person with ASD can have due to his characteristics. However, it cannot be said that there has been a complete change of the image: the old cliches, as a rule, manifest themselves at a more latent level of grammatical constructions and semiotic meanings.

scholarly journals Panel of serum miRNAs as potential non-invasive biomarkers for pancreatic ductal adenocarcinoma

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Imteyaz Ahmad Khan ◽  
Safoora Rashid ◽  
Nidhi Singh ◽  
Sumaira Rashid ◽  
Vishwajeet Singh ◽  
...  
Keyword(s):  
Next Generation Sequencing ◽  
Pancreatic Ductal Adenocarcinoma ◽  
Early Stage ◽  
Ductal Adenocarcinoma ◽  
Next Generation ◽  
Serum Samples ◽  
Tissue Samples ◽  
Non Invasive ◽  
Specific Symptoms ◽  
Generation Sequencing

AbstractEarly-stage diagnosis of pancreatic ductal adenocarcinoma (PDAC) is difficult due to non-specific symptoms. Circulating miRNAs in body fluids have been emerging as potential non-invasive biomarkers for diagnosis of many cancers. Thus, this study aimed to assess a panel of miRNAs for their ability to differentiate PDAC from chronic pancreatitis (CP), a benign inflammatory condition of the pancreas. Next-generation sequencing was performed to identify miRNAs present in 60 FFPE tissue samples (27 PDAC, 23 CP and 10 normal pancreatic tissues). Four up-regulated miRNAs (miR-215-5p, miR-122-5p, miR-192-5p, and miR-181a-2-3p) and four down-regulated miRNAs (miR-30b-5p, miR-216b-5p, miR-320b, and miR-214-5p) in PDAC compared to CP were selected based on next-generation sequencing results. The levels of these 8 differentially expressed miRNAs were measured by qRT-PCR in 125 serum samples (50 PDAC, 50 CP, and 25 healthy controls (HC)). The results showed significant upregulation of miR-215-5p, miR-122-5p, and miR-192-5p in PDAC serum samples. In contrast, levels of miR-30b-5p and miR-320b were significantly lower in PDAC as compared to CP and HC. ROC analysis showed that these 5 miRNAs can distinguish PDAC from both CP and HC. Hence, this panel can serve as a non-invasive biomarker for the early detection of PDAC.

scholarly journals Genes associated with inflammation and bone remodeling are highly expressed in the bone of patients with the early-stage cam-type femoroacetabular impingement

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Guanying Gao ◽  
Ruiqi Wu ◽  
Rongge Liu ◽  
Jianquan Wang ◽  
Yingfang Ao ◽  
...  
Keyword(s):  
Gene Expression ◽  
Bone Tissue ◽  
Bone Remodeling ◽  
Femoroacetabular Impingement ◽  
Early Stage ◽  
Control Group ◽  
Tissue Samples ◽  
Expression Levels ◽  
Normal Bone ◽  
Impingement Zone

Abstract Background Recent studies have shown high expression levels of certain inflammatory, anabolic, and catabolic genes in the articular cartilage from the impingement zone of the hips with femoroacetabular impingement (FAI), representing an increased metabolic state. Nevertheless, little is known about the molecular properties of bone tissue from the impingement zone of hips with FAI. Methods Bone tissue samples from patients with early-stage cam-type FAI were collected during hip arthroscopy for treatment of cam-type FAI. Control bone tissue samples were collected from six patients who underwent total hip replacement because of a femoral neck fracture. Quantitative real-time polymerase chain reaction (PCR) was performed to determine the gene expression associated with inflammation and bone remodeling. The differences in the gene expression in bone tissues from the patients with early-stage cam-type FAI were also evaluated based on clinical parameters. Results In all, 12 patients with early-stage cam-type FAI and six patients in the control group were included in this study. Compared to the control samples, the bone tissue samples from patients with FAI showed higher expression levels of interleukin-6 (IL-6), alkaline phosphatase (ALP), receptor activator of nuclear factor-kB ligand (RANKL), and osteoprotegerin (OPG) (P < 0.05). IL-1 expression was detected only in the control group. On the other hand, there was no significant difference in IL-8 expression between the patients with FAI and the control group. The patients with FAI having a body mass index (BMI) of >24 kg/m2 showed higher ALP expression (P < 0.05). Further, the expression of IL-6 and ALP was higher in the patients with FAI in whom the lateral center-edge angle was >30° (P < 0.05). Conclusions Our results indicated the metabolic condition of bone tissues in patients with early-stage cam-type FAI differed from that of normal bone in the femoral head-neck junction. The expression levels of the genes associated with inflammation and bone remodeling were higher in the bone tissue of patients with early-stage cam-type FAI than in the patients with normal bone tissue.

Sign in / Sign up

Export Citation Format

Share Document