Prenatal Drug Use: Neonatal Effects and the Neonatal Withdrawal Syndrome

2020 ◽  
Author(s):  
Enrique M. Ostrea ◽  
Josef Cortez ◽  
Neil Joseph B. Alviedo ◽  
Felix De Paz Bañadera ◽  
Lilia C. De Jesus ◽  
...  
1998 ◽  
Vol 3 (2) ◽  
pp. 159-170 ◽  
Author(s):  
ZALMAN WEINTRAUB ◽  
YORAM BENTAL ◽  
ANITA OLIVAN ◽  
AVI ROTSCHILD

2014 ◽  
Vol 245 ◽  
pp. e33-e35 ◽  
Author(s):  
Simona Pichini ◽  
Maria Concetta Rotolo ◽  
Jordi García ◽  
Noelia Girona ◽  
Lorna Leal ◽  
...  

2011 ◽  
Vol 23 (3) ◽  
pp. 777-788 ◽  
Author(s):  
Philip A. Fisher ◽  
Barry M. Lester ◽  
David S. DeGarmo ◽  
Linda L. Lagasse ◽  
Hai Lin ◽  
...  

AbstractThe negative effects of prenatal substance exposure on neurobiological and psychological development and of early adversity are clear, but little is known about their combined effects. In this study, multilevel analyses of the effects of prenatal substance exposure and early adversity on the emergence of neurobehavioral disinhibition in adolescence were conducted. Neurobehavioral disinhibition has previously been observed to occur frequently in multiproblem youth from high-risk backgrounds. In the present study, neurobehavioral disinhibition was assessed via behavioral dysregulation and poor executive function composite measures. Data were drawn from a prospective longitudinal investigation of prenatal substance exposure that included 1,073 participants followed from birth through adolescence. The results from latent growth modeling analyses showed mean stability but significant individual differences in behavioral dysregulation and mean decline with individual differences in executive function difficulties. Prior behavioral dysregulation predicted increased executive function difficulties. Prenatal drug use predicted the emergence and growth in neurobehavioral disinhibition across adolescence (directly for behavioral dysregulation and indirectly for executive function difficulties via early adversity and behavioral dysregulation). Prenatal drug use and early adversity exhibited unique effects on growth in behavioral dysregulation; early adversity uniquely predicted executive function difficulties. These results are discussed in terms of implications for theory development, social policy, and prevention science.


2013 ◽  
Vol 45 (1) ◽  
pp. 113-117 ◽  
Author(s):  
Kimberly A. Hekman ◽  
Violanda I. Grigorescu ◽  
Lorraine L. Cameron ◽  
Corinne E. Miller ◽  
Ruben A. Smith

PEDIATRICS ◽  
1973 ◽  
Vol 52 (5) ◽  
pp. 714-716
Author(s):  
Barry H. Rumack ◽  
Phillip A. Walravens

Intrauterine exposure to many drugs and chemicals is known to result in adverse effects on the fetus or neonate.1 A withdrawal syndrome in the newborn has been described for only a few agents the most prominent of which are in the narcotic group.2 Maternal barbiturate exposure also causes a syndrome with somewhat different features in the neonate.3 Adult withdrawal after discontinuation of drugs has been demonstrated with several additional medications including diazepam (Valium), chlordiazepoxide (Librium), meprobamate (Milltown), and ethchlorvynol (Placidyl).4,5 There is little reason to believe that a neonate would be spared from withdrawal of these drugs after maternal use. We report a case of withdrawal in a neonate from ethchlorvinyl documented by laboratory confirmation.6


2009 ◽  
Vol 62 (3-4) ◽  
pp. 181-184 ◽  
Author(s):  
Tatjana Radunovic-Gojkovic ◽  
Gordana Velisavljev-Filipovic

Introduction. Maternal drug abuse has increased over the past decade. It has a multiple negative influence on a pregnant woman, as well as her newborn. Practically, every drug taken during pregnancy crosses the placenta, and the developing fetus may also be affected by the effects of a drug. After delivery, an infant of a drug-abusing mother may potentially develop neonatal withdrawal syndrome. Existing studies on the neonatal effects of drug exposure in utero are subject to many factors. Many studies have relied on the history obtained from the mother, which is innacurate. Urine testing for drug abuse does not reflect exposure to a drug through pregnancy and does not provide quantitative information. Social and economic deprivation is common among drug abusers, and this factor has a major effect on long term studies of infant outcome. The purpose of this article is to underline the problems during management of a neonatal withdrawal syndrom, and growing incidence of it in our society. Case report. A case of an infant of a heroin-abusing mother is reported. Conclusion. It is very important to take care of an infant with neonatal withdrawal syndrome, but it is also of a great importance to supervise these children for a long period of time.


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