RETINOPATHY AND PAPILLEDEMA IN CYANOTIC CONGENITAL HEART DISEASE

PEDIATRICS ◽  
1972 ◽  
Vol 49 (2) ◽  
pp. 243-249
Author(s):  
Robert A. Petersen ◽  
Amnon Rosenthal
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Congenital Heart ◽  
Arterial Oxygen Saturation ◽  
Venous Pressure ◽  
Cyanotic Congenital Heart Disease ◽  
Arterial Oxygen ◽  
Central Venous ◽  
Arterial Pco2 ◽  
Retinal Blood Vessels

A retinopathy consisting of dilated, tortuous retinal blood vessels and, in some patients, papilledema may occur in cyanotic congenital heart disease (CHD). Of 83 patients with cyanotic CHD examined ophthalmologically, 52 exhibited some degree of the retinopathy, and 12 had papilledema. The severity of the fundus changes was closely related to the patient's arterial oxygen saturation and hematocrit and bore no relationship to arterial Pco2, pH, central venous pressure, type of cardiac malformation, or the patient's age.

The Ventilatory Response to Hypoxia during Exercise in Cyanotic Congenital Heart Disease

1973 ◽  
Vol 45 (1) ◽  
pp. 99-105 ◽  
Author(s):  
M. R. H. Taylor
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Congenital Heart ◽  
Ventilatory Response ◽  
Arterial Oxygen Saturation ◽  
Haemoglobin Concentration ◽  
Cyanotic Congenital Heart Disease ◽  
Arterial Oxygen ◽  
Normal Adults ◽  
Ventilatory Response To Hypoxia

1. In contrast to the diminished ventilatory response to hypoxia which has been found at rest in cyanotic congenital heart disease, hyperventilation was noted on exercise in children who were cyanosed. 2. Sixteen children had low arterial oxygen saturations on exercise and thirteen of these hyperventilated by an amount similar to that reported in normal adults breathing hypoxic gas mixtures. 3. The three children who had little ventilatory response in relation to the increase of hypoxia during exercise all had a triad of long-standing cyanosis starting early in life, high haemoglobin concentration and low arterial oxygen saturation at rest in air.

METABOLIC ACIDOSIS IN CHILDREN WITH SEVERE CYANOTIC CONGENITAL HEART DISEASE

PEDIATRICS ◽  
1963 ◽  
Vol 31 (2) ◽  
pp. 251-254
Author(s):  
Norman L. Gootman ◽  
Emile M. Scarpelli ◽  
Abraham M. Rudolph
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Metabolic Acidosis ◽  
Congenital Heart ◽  
Respiratory Activity ◽  
Cyanotic Congenital Heart Disease ◽  
Arterial Pco2 ◽  
Respiratory Compensation ◽  
Pulmonary Flow ◽  
High Level

Four children with severe cyanotic congenital heart disease and markedly reduced effective pulmonary blood flow were studied by cardiac catheterization. All children were severely hypoxic and acidotic, while the sytemic arterial pCO2 was relatively normal. These factors tended to maintain respiratory activity at a high level. However, due to the decreased pulmonary flow, respiratory compensation for the acidosis was ineffective. The chronic, uncompensated metabolic acidosis and hypoxemia suggested that (1) anaerobic tissue metabolism is significant, and (2) renal function may be compromised, in children with severe cyanotic congenital heart disease.

Hypoxemia and Auditory Reaction Time in Congenital Heart Disease

1977 ◽  
Vol 45 (2) ◽  
pp. 595-600 ◽  
Author(s):  
Ruth B. Aisenberg ◽  
Amnon Rosenthal ◽  
Peter H. Wolff ◽  
Alexander S. Nadas
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Reaction Time ◽  
Congenital Heart ◽  
Arterial Oxygen Saturation ◽  
Normal Subjects ◽  
Arterial Oxygen ◽  
Performance Deficits ◽  
Visual Tasks ◽  
Auditory Reaction Time

The purpose of this study was to determine if previously documented performance deficits of patients with cyanotic congenital heart disease are peculiar to centrally mediated visual tasks or are also manifested on tests of other centrally mediated sensory functions such as hearing. A simple auditory reaction time test was, therefore, performed on 239 patients with congenital heart disease, 43 of whom were cyanotic. Results indicated that (a) there is no significant relationship between level of arterial oxygen saturation and auditory RT. (b) Auditory RT for the group as a whole declines until the mid-teens and then rises, a pattern at variance with that of normal subjects. (c) The auditory RT of females was significantly higher, i.e., slower, than that of males.

Experience with the Glenn anastomosis in the adult with cyanotic congenital heart disease

1999 ◽  
Vol 9 (3) ◽  
pp. 257-265 ◽  
Author(s):  
Amalia Elizari ◽  
Jane Somerville
Keyword(s):  
Congenital Heart ◽  
Arterial Oxygen Saturation ◽  
Venous Pressure ◽  
Cyanotic Congenital Heart Disease ◽  
Arterial Supply ◽  
Arterial Oxygen ◽  
Early Complications ◽  
Arteriovenous Fistulas ◽  
Second Stage ◽  
Pulmonary Arterial

AbstractA clinical study on the outcomes of Glenn anastomoses performed since 1987 in eight consecutive patients aged ≥16 years, and in two performed earlier, showed poor results. One badly selected patient died early as a consequence of high venous pressure, while a further seven had early complications. Seven of eight hospital survivors were followed for 1–10 (median 4.2) years with two deaths (1 and 4 years later). Of the remaining five patients, two improved temporarily, but increased arterial oxygen saturation was not maintained after 6 months. The two patients who had undergone a Glenn anastomosis 10 and 34 years earlier were shown to have pulmonary arteriovenous fistulas. The Glenn anastomosis in these older patients is associated with high rates of complication and appears not to give adequate palliation, particularly when it is the only source of pulmonary blood supply. In the adult, the Glenn anastomosis can be used as a staging procedure for Fontan-type surgery, but must be combined with another source of pulmonary arterial supply. Any adult having a Glenn anastomosis, particularly without another source of pulmonary arterial supply, should be warned of the possibility of worsening of cyanosis and symptoms. The second stage of the procedure may need to be performed soon after the first should the hypoxia prove intolerable.

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