Unsuspected Hyperosmolality of Oral Solutions Contributing to Necrotizing Enterocolitis in Very-Low-Birth-Weight Infants

PEDIATRICS ◽  
1977 ◽  
Vol 60 (4) ◽  
pp. 535-538
Author(s):  
DIANA M. WILLIS ◽  
JOANN CHABOT ◽  
INGEBORG C. RADDE ◽  
GRAHAM W. CHANCE
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Necrotizing Enterocolitis ◽  
Neonatal Intensive Care ◽  
Very Low Birth Weight ◽  
Neonatal Intensive Care Units ◽  
Low Birth Weight Infants ◽  
Umbilical Vessel ◽  
Causative Factors ◽  
Nutritional Studies

In recent years necrotizing enterocolitis (NEC) has become a major problem in neonatal intensive care units. Recent incidences as high as 8% in all infants with a birth weight less than 2.5 kg and 14% in those with a birth weight less than 1.5 kg have been reported from one center.1Despite intensive searches for possible causative factors, no definite entity has been identified, but asphyxia,2 circulatory changes associated with exchange transfusion,3 umbilical vessel catheterization,4 immature immune status,5infection,6-8 and hypertonic feedings9 have all been implicated. In the course of a series of nutritional studies involving thriving very-low-birth-weight infants we

Device-associated pneumonia of very low birth weight infants in Polish Neonatal Intensive Care Units

2016 ◽  
Vol 61 (1) ◽  
pp. 90-95 ◽  
Author(s):  
Jadwiga Wójkowska-Mach ◽  
T. Allen Merritt ◽  
Maria Borszewska-Kornacka ◽  
Joanna Domańska ◽  
Ewa Gulczyńska ◽  
...  
Keyword(s):  
Intensive Care ◽  
Birth Weight ◽  
Low Birth Weight ◽  
Intensive Care Units ◽  
Neonatal Intensive Care ◽  
Very Low Birth Weight ◽  
Neonatal Intensive Care Units ◽  
Low Birth Weight Infants

scholarly journals Outcome of primary peritoneal drainage in perforated necrotizing enterocolitis: an experience with 96 infants

2021 ◽  
Author(s):  
Kumar Abdul Rashid ◽  
Reyaz Ahmad Wani ◽  
Shafat Ahmad Tak ◽  
Omar Masood ◽  
Amat U. Samie ◽  
...  
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Necrotizing Enterocolitis ◽  
Neonatal Intensive Care ◽  
Very Low Birth Weight ◽  
Exploratory Laparotomy ◽  
Extremely Low Birth Weight ◽  
Major Surgery ◽  
Low Birth Weight Infants ◽  
Peritoneal Drainage

Background: Necrotizing enterocolitis is a life-threatening inflammation of neonatal intestine of multifactorial etiology. In early stages, medical management is considered; while as a transmural disease with pneumatosis or perforation needs surgical attention. Primary peritoneal drainage has evolved as an alternative to classic exploratory laparotomy especially in sick preterm and very low birth weight infants.Methods: In our study, we tried to employ primary peritoneal drainage as an initial intervention in all surgical necrotizing enterocolitis patients and analyzed the results and final outcome in terms of total days in neonatal intensive care unit, total parenteral nutrition days, days to start oral feeds, need for laparotomy, mortality and other complications.Results: Around one-third patients were either very low or extremely low birth weight and 80% patients were preterm. Primary peritoneal drainage was successful without need for laparotomy in around 65% of patients. In the rest 34 patients, 24 were subjected to rescue laparotomy, while 10 could not be stabilized for major surgery. Overall mortality was 29.16%.Conclusions: Early bedside primary peritoneal drainage can be employed in all cases of NEC with perforation with rescue laparotomy to be determined by subsequent monitoring. This strategy seems to be safe and cost-effective in a resource challenged set up and lifesaving in sick and extremely low birth weight infants.

scholarly journals Lipocalin-2 and calprotectin as stool biomarkers for predicting necrotizing enterocolitis in premature neonates

2021 ◽  
Author(s):  
Marie-Pier Thibault ◽  
Éric Tremblay ◽  
Chantal Horth ◽  
Aube Fournier-Morin ◽  
David Grynspan ◽  
...  
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Necrotizing Enterocolitis ◽  
Neonatal Intensive Care ◽  
Very Low Birth Weight ◽  
List Type ◽  
Lipocalin 2 ◽  
Low Birth Weight Infants ◽  
Biomarker Signature ◽  
Fecal Biomarkers

Abstract Background Necrotizing enterocolitis (NEC) is a major challenge for premature infants in neonatal intensive care units and efforts toward the search for indicators that could be used to predict the development of the disease have given limited results until now. Methods In this study, stools from 132 very low birth weight infants were collected daily in the context of a multi-center prospective study aimed at investigating the potential of fecal biomarkers for NEC prediction. Eight infants (~6%) received a stage 3 NEC diagnosis. Their stools collected up to 10 days before diagnosis were included and matched with 14 non-NEC controls and tested by ELISA for the quantitation of eight biomarkers. Results Biomarkers were evaluated in all available stool samples leading to the identification of lipocalin-2 and calprotectin as the two most reliable predicting markers over the 10-day period prior to NEC development. Pooling the data for each infant confirmed the significance of lipocalin-2 and calprotectin, individually and in combination 1 week in advance of the NEC clinical diagnosis. Conclusions The lipocalin-2 and calprotectin tandem represents a significant biomarker signature for predicting NEC development. Although not yet fulfilling the “perfect biomarker” criteria, it represents a first step toward it. Impact Stool biomarkers can be used to predict NEC development in very low birth weight infants more than a week before the diagnosis. LCN2 was identified as a new robust biomarker for predicting NEC development, which used in conjunction with CALPRO, allows the identification of more than half of the cases that will develop NEC in very low birth weight infants. Combining more stool markers with the LCN2/CALPRO tandem such as PGE2 can further improve the algorithm for the prediction of NEC development.

Radiation exposure of very-low-birth-weight infants in neonatal intensive care units in Korea

2018 ◽  
Vol 53 (4) ◽  
pp. 279-286 ◽  
Author(s):  
M.J. Park ◽  
S.S. Kim ◽  
G.Y. Park ◽  
H.S. Hong
Keyword(s):  
Intensive Care ◽  
Birth Weight ◽  
Low Birth Weight ◽  
Radiation Exposure ◽  
Neonatal Intensive Care ◽  
Very Low Birth Weight ◽  
Neonatal Intensive Care Units ◽  
Radiation Doses ◽  
Low Birth Weight Infants ◽  
X Ray

To our knowledge, no study has reported the radiation doses of neonates admitted to neonatal intensive care units (NICUs) in Korea. Therefore, we evaluated the radiation frequency and dose of radiation performed in NICUs using mobile X-ray machines. We retrospectively analyzed the number of radiographs and doses among 290 very low-birth-weight infants (VLBWIs) admitted at our hospital between 2011 and 2016. We compared X-ray frequencies and radiation doses according to clinical characteristics and morbidities. The entrance surface doses (ESDs) were calculated using the non-dosimeter dosimetry formula. The median number of radiographs per infant was 26, and about 25% neonates had over 50 radiographs. The number of radiographs taken was higher for infants with low-birth-weight (LBW), respiratory distress syndrome, bronchopulmonary dysplasia, and longer central venous catheterization duration (p < 0.001 for all). The cumulative ESD was 0.18 to 9.89 mGy, and the ESD per radiograph was 0.049 to 0.069 mGy. The LBW and the more severe the neonates’ condition, the greater was the radiation exposure. It is difficult to reduce the number of radiographic examinations, but the quality of examinations must be improved without compromising patient care. Additional studies are needed to minimize the cumulative exposure dose and achieve optimal image quality.

Variations of Apgar score of very low birth weight infants in different neonatal intensive care units

2009 ◽  
Vol 98 (9) ◽  
pp. 1433-1436 ◽  
Author(s):  
Mario Rüdiger ◽  
Helmut Küster ◽  
Egbert Herting ◽  
Angelika Berger ◽  
Christoph Müller ◽  
...  
Keyword(s):  
Intensive Care ◽  
Birth Weight ◽  
Low Birth Weight ◽  
Intensive Care Units ◽  
Apgar Score ◽  
Neonatal Intensive Care ◽  
Very Low Birth Weight ◽  
Neonatal Intensive Care Units ◽  
Low Birth Weight Infants

Early-onset Infections of Very-low-birth-weight Infants in Polish Neonatal Intensive Care Units

2012 ◽  
Vol 31 (7) ◽  
pp. 691-695 ◽  
Author(s):  
Jadwiga Wójkowska-Mach ◽  
Maria Borszewska-Kornacka ◽  
Joanna Domańska ◽  
Jausz Gadzinowski ◽  
Ewa Gulczyńska ◽  
...  
Keyword(s):  
Intensive Care ◽  
Birth Weight ◽  
Low Birth Weight ◽  
Intensive Care Units ◽  
Early Onset ◽  
Neonatal Intensive Care ◽  
Very Low Birth Weight ◽  
Neonatal Intensive Care Units ◽  
Low Birth Weight Infants
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