Serum 25-Hydroxyvitamin D Concentrations in Sudden Infant Death Syndrome

PEDIATRICS ◽  
1980 ◽  
Vol 65 (6) ◽  
pp. 1137-1139
Author(s):  
Laura S. Hillman ◽  
Marilyn Erickson ◽  
John G. Haddad
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Sudden Infant Death Syndrome ◽  
Infant Death ◽  
Sudden Infant Death ◽  
Near Miss ◽  
Sudden Infant ◽  
Hydroxyvitamin D ◽  
25 Hydroxyvitamin D ◽  
The Mean

Among the many theories put forth to explain sudden infant death syndrome (SIDS) is a theory of vitamin D deficiency. 25-Hydroxyvitamin D (25-OHD) serum concentrations were measured in 31 SIDS and 24 postmortem control infants. 25-OHD was 19.0 ± 7.9 mg/ml in SIDS, 16.9 ± 5.2 ng/ml in acute death control infants, and 11.9 ± 4.4 ng/ml in in-hospital deaths. For four "near miss" infants the mean serum 25-OHD concentration was 21.1 ± 4.1 ng/ml. The mean serum 25-OHD concentration of 39 living premature or small-for-gestational-age infants at 3 months of age was 26 ± 9.9. Serum calcium and serum copper concentrations were also the same in SIDS and control infants. Parathyroid hormone was measured in ten and was detectable in five SIDS infants. These data eliminate a simple vitamin D deficiency or a 25-OHD deficiency as a significant contribution to the pathophysiology of SIDS.

Diaphragm Strength in Near-Miss Sudden Infant Death Syndrome

PEDIATRICS ◽  
1982 ◽  
Vol 69 (6) ◽  
pp. 782-784
Author(s):  
Charles B. Scott ◽  
Bruce G. Nickerson ◽  
Charles W. Sargent ◽  
Paula C. Dennies ◽  
Arnold C. G. Platzker ◽  
...  
Keyword(s):  
Sudden Infant Death Syndrome ◽  
Infant Death ◽  
Sudden Infant Death ◽  
Near Miss ◽  
Diaphragm Muscle ◽  
Control Group ◽  
Sudden Infant ◽  
Transdiaphragmatic Pressure ◽  
Airway Occlusion ◽  
The Mean

Diaphragm muscle strength was measured as maximal transdiaphragmatic pressure during airway occlusion in ten near-miss sudden infant death syndrome infants aged 4.1 ± 0.6 (SE) months post-term, range 2 to 7 months, and ten control infants aged 4.5 ± 0.8 months post-term, range 0.8 to 8 months. In the near-miss sudden infant death syndrome group, the mean maximal transdiaphragmatic pressure was 106 ± 6 cm H2O, range 78 to 132 cm H2O, compared with a mean maximal transdiaphragmatic pressure of 86 ± 4 cm H2O, range 69 to 106 cm H2O, in the control group. Diaphragm strength is normal or increased in near-miss sudden infant death syndrome infants.

Serum 25-Hydroxyvitamin D Concentrations in Sudden Infant Death Syndrome

PEDIATRICS ◽  
1981 ◽  
Vol 67 (4) ◽  
pp. 569-569
Author(s):  
Laura S. Hillman ◽  
Marilyn Erickson ◽  
John G. Haddad
Keyword(s):  
Sudden Infant Death Syndrome ◽  
Infant Death ◽  
Sudden Infant Death ◽  
Sudden Infant ◽  
Hydroxyvitamin D ◽  
Children's Hospital ◽  
School Of Medicine ◽  
25 Hydroxyvitamin D ◽  
Jewish Hospital ◽  
Washington University

In the article "Serum-25-hydroxyvitamin D Concentrations in Sudden Infant Death Syndrome" by Hillman et al (Pediatrics 65:1137-1139, 1980) authors and affiliations should read: Laura S. Human, M.D., Marilyn Erickson, and John G. Haddad, Jr., MD. From the Edward Mallinckrodt Department of Pediatrics, Washington University School of Medicine, St Louis Children's Hospital; St Louis County Medical Examiner's Office and Department of Pathology, St Louis University; and Division of Metabolism, The Jewish Hospital of St Louis, St. Louis.

The Uvula and Sudden Infant Death Syndrome

PEDIATRICS ◽  
1984 ◽  
Vol 74 (2) ◽  
pp. 319-320
Author(s):  
CHRISTIAN GUILLEMINAULT
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Sudden Infant Death Syndrome ◽  
Infant Death ◽  
Sleep Apnea Syndrome ◽  
Sudden Infant Death ◽  
Term Infant ◽  
Near Miss ◽  
Sudden Infant ◽  
Obstructive Sleep

In Reply.— Harpey and Renault postulate a relationship between the uvula, obstructive sleep apnea, and sudden infant death syndrome. Although I believe that obstructive sleep apnea syndrome may be one of the mechanisms leading to sudden infant death syndrome, this speculation is extremely controversial. I do concur with Harpey and Renault that obstructive sleep apnea can trigger esophageal reflux. A segment from a sleep recording of a 9-week-old, full-term infant with near-miss sudden infant death syndrome is presented in the Figure.

Arousal responses in near-miss sudden infant death syndrome and in normal infants

1982 ◽  
Vol 101 (6) ◽  
pp. 911-917 ◽  
Author(s):  
Kristine McCulloch ◽  
Robert T. Brouillette ◽  
Anthony J. Guzzetta ◽  
Carl E. Hunt
Keyword(s):  
Sudden Infant Death Syndrome ◽  
Infant Death ◽  
Sudden Infant Death ◽  
Near Miss ◽  
Sudden Infant

Postnatal Growth Preceding Sudden Infant Death Syndrome

PEDIATRICS ◽  
1994 ◽  
Vol 94 (4) ◽  
pp. 456-461
Author(s):  
John G. Brooks ◽  
Ruth E. Gilbert ◽  
Peter J. Flemming ◽  
Peter J. Berry ◽  
Jean Golding
Keyword(s):  
Growth Rate ◽  
Sudden Infant Death Syndrome ◽  
Infant Death ◽  
Final Analysis ◽  
Sudden Infant Death ◽  
Postnatal Growth ◽  
Bottle Feeding ◽  
Sudden Infant ◽  
Age At Death ◽  
The Mean

Objective. To compare postnatal growth preceding the sudden infant death syndrome (SIDS) with that of age matched controls. Design. Retrospective case-control study. Each SIDS victim was matched with two controls on date of parental interview, postnatal age, and neighborhood. Clinical and demographic data were collected by parental interview and by review of medical records, and interval body weights were obtained from health visitors' records. Study population. All infants dying of SIDS between 1 May, 1987 and 30 April, 1989 in a geographically defined region consisting of four health districts in Avon and North Somerset in southwest England. Seventy-eight of the 99 SIDS victims and 139 of 156 control infants were included in the final analysis. Results. There was no significant difference between SIDS victims and the controls in either of the two indices of postnatal growth which were analyzed. The mean growth rates (± 1 SEM) between birth and the last live weight (age equivalent weight for control infants) were 27.1 ± 1.0 g/day for the SIDS cases and 28.3 ± 1.5 g/day for the control infants. The mean growth rate (± 1 SEM) between the last two live weights were 31.5 ± 2.9 and 24.9 ± 2.1 g/day for the SIDS and control infants, respectively. Stratification of the infants by sex, gestational age, maternal smoking during pregnancy, breast versus bottle feeding, or age at death, did not result in any significant differences between SIDS and controls in either of the indices of postnatal growth rate. The 20 SIDS cases which were excluded from the final analysis did not differ from 78 whose data was analyzed, with regard to established SIDS risk factors, age at death, or postmortem weight. Conclusions. No difference was found between the postnatal growth of SIDS victims and that of age matched control infants.

Mixed and Obstructive Sleep Apnea and Near Miss for Sudden Infant Death Syndrome: 2. Comparison of Near Miss and Normal Control Infants by Age

PEDIATRICS ◽  
1979 ◽  
Vol 64 (6) ◽  
pp. 882-891 ◽  
Author(s):  
Christian Guilleminault ◽  
Ronald Ariagno ◽  
Rowena Korobkin ◽  
Lynn Nagel ◽  
Roger Baldwin ◽  
...  
Keyword(s):  
Normal Control ◽  
Sudden Infant Death Syndrome ◽  
Infant Death ◽  
Periodic Breathing ◽  
Sudden Infant Death ◽  
Near Miss ◽  
Sudden Infant ◽  
Obstructive Apnea ◽  
Respiratory Events ◽  
Obstructive Sleep

Twenty-nine full-term near miss for sudden infant death syndrome (SIDS) and 30 normal control infants underwent 24-hour polygraphic monitoring. Several types of respiratory events during sleep (eg, central, mixed, and obstructive apnea, periodic breathing) were defined and tabulated. Analysis of these respiratory variables and comparison of groups of near miss and control infants indicated that between 3 weeks and 4½ months of age only one variable was consistently different at a statistically significant level: the number of mixed and obstructive apnea 3 seconds during total sleep time. This study also showed an increase in mixed and obstructive respiratory events during sleep at 6 weeks of age in control as well as in near miss infants.

Incidence of Apnea in Siblings of Sudden Infant Death Syndrome Victims Studied at Home

PEDIATRICS ◽  
1982 ◽  
Vol 70 (1) ◽  
pp. 128-131
Author(s):  
Dorothy H. Kelly ◽  
Joseph Twanmoh ◽  
Daniel C. Shannon
Keyword(s):  
Sudden Infant Death Syndrome ◽  
Infant Death ◽  
Chronic Hypoxia ◽  
Breathing Pattern ◽  
Respiratory Control ◽  
Periodic Breathing ◽  
Sudden Infant Death ◽  
Near Miss ◽  
Sudden Infant ◽  
Sibling Group

Victims of sudden infant death syndrome (SIDS) have been shown to have pathologic abnormalities consistent with chronic hypoxia.1-7 Two groups of infants at high risk of dying of SIDS, near miss infants and subsequent siblings of SIDS victims, have been studied in attempts to demonstrate physiologic abnormalities that could account for these pathologic findings. Investigators have found abnormalities in breathing pattern and the respiratory control system in the former consisting of prolonged sleep apnea, excessive short apnea, periodic breathing, hypoventilation, and depressed response to hypercarbia.8-13 However, studies in the SIDS sibling group have demonstrated varying results of excessive periodic breathing in the home14 and decreased apnea in the laboratory.15

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