Prevention of Perinatal Transmission of Chronic Hepatitis B Surface Antigen (HBsAg) Carrier State

PEDIATRICS ◽  
1984 ◽  
Vol 73 (3) ◽  
pp. 409-409
Author(s):  
JAMES CHIN
Keyword(s):  
Chronic Hepatitis ◽  
Pregnant Woman ◽  
Hepatitis B ◽  
Surface Antigen ◽  
Hepatitis B Surface Antigen ◽  
Perinatal Transmission ◽  
Carrier State ◽  
Hbsag Carrier ◽  
B Virus ◽  
Very High

In Reply.— It is well documented that the risk of a pregnant woman—who is a hepatitis B surface antigen (HBsAg) carrier and who also has detectable hepatitis Be antigen (HBeAg)—transmitting a hepatitis B virus (HBV) infection to her infant at birth, which would result in chronic HBsAg carriage, is very high (up to 90%). Women who are HBsAg positive but HBsAg negative and who have no detectable antibody to HBeAg (anti-HBe) are considered of intermediate infectivity.

Prevention of Perinatal Transmission of Chronic Hepatitis B Surface Antigen (HBsAg) Carrier State

PEDIATRICS ◽  
1984 ◽  
Vol 73 (3) ◽  
pp. 409-410
Author(s):  
FRANK R. SINATRA ◽  
MYRON J. TONG
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis B ◽  
Chronic Hepatitis B ◽  
Surface Antigen ◽  
Hepatitis B Surface Antigen ◽  
Perinatal Transmission ◽  
Carrier State ◽  
European Ancestry ◽  
Hbsag Carrier ◽  
Original Report

In Reply.— In response to the letter by Salvioli and co-workers, although we would agree that the incidence of perinatal transmission of hepatitis B from HBeAg-negative mothers is low, the consequences may be severe. One of the three infants in our study was born to a HBeAg-negative and anti-HBe-positive American mother of European ancestry.1 Following publication of our original report, we cared for an infant who developed fulminant icteric hepatitis 8 weeks after being born to a HBeAg-negative and anti-HBe-positive mother.

Prevention of Perinatal Transmission of Chronic Hepatitis B Surface Antigen (HBsAg) Carrier State

PEDIATRICS ◽  
1984 ◽  
Vol 73 (3) ◽  
pp. 408-409
Author(s):  
GIAN PAOLO SALVIOLI ◽  
GIACOMO FALDELLA ◽  
ROSINA ALESSANDRONI ◽  
MARCELLO LANARI
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Hepatitis B Surface Antigen ◽  
Perinatal Transmission ◽  
Carrier State ◽  
Hbsag Carrier ◽  
B Virus ◽  
The World ◽  
Positive Carrier

To the Editor.— All over the world, groups with the highest risk of hepatitis B virus (HBV) infection are being identified in order to define correct immunoprophylaxis programs.1,2 It has been suggested that all infants born to HBsAg-positive mothers, irrespective of whether they are HBeAg positive or not, are in need of immediate protection.3,4 In support of this necessity, Sinatra and colleagues5 report three cases of perinatal transmitted acute icteric hepatitis B in infants born to HBsAg-positive and anti-HBe-positive carrier mothers.

scholarly journals Binding of biotin to hepatitis B surface antigen: a possible pitfall in immunohistochemistry.

1989 ◽  
Vol 37 (4) ◽  
pp. 551-554 ◽  
Author(s):  
J J van den Oord ◽  
F Facchetti ◽  
C de Wolf-Peeters ◽  
V J Desmet
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Surface Antigen ◽  
Disulfide Bonds ◽  
Hepatitis B Surface Antigen ◽  
B Virus ◽  
Infected Liver ◽  
Hepatitis B Viral Infection ◽  
Positive Results

We report on the binding of biotin, and hence of biotinylated antibodies and lectins, to ground glass hepatocytes and liver cell membranes in chronic hepatitis B viral infection. This binding is of low affinity, and was proved to be directed at the hepatitis B surface antigen, presumably at its disulfide bonds. To avoid false-positive results, this affinity should be considered in the interpretation of immunohistochemical stainings of hepatitis B virus-infected liver tissue with biotinylated reagents.

Detection of hepatitis B virus in the cerumen of patients with chronic hepatitis B infection

2013 ◽  
Vol 127 (11) ◽  
pp. 1065-1066 ◽  
Author(s):  
A Eftekharian ◽  
H Moghaddasi ◽  
L Gachkar ◽  
S S A Amlashi
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Chronic Hepatitis B ◽  
Surface Antigen ◽  
Hepatitis Virus ◽  
Hepatitis B Surface Antigen ◽  
Polymerase Chain Reaction Test ◽  
Hepatitis B Virus Dna ◽  
B Virus

AbstractObjective:To investigate hepatitis B virus DNA in the cerumen of hepatitis B virus infected patients.Methods:This study comprised 30 confirmed cases of chronic hepatitis B. Patients' serum samples were examined for hepatitis B surface antigen and antibodies using enzyme immunoassay systems. The presence of hepatitis B virus DNA in cerumen was investigated using a polymerase chain reaction test.Results:All of the samples were positive for hepatitis B surface antigen and negative for hepatitis B surface antibodies. Hepatitis virus DNA was detected in two cerumen samples (6.6 per cent of patients).Conclusion:Cerumen can be a potential source of transmission of hepatitis B virus.

scholarly journals Serum immunoconglutinin titers during acute and chronic hepatitis B virus infection

1980 ◽  
Vol 28 (3) ◽  
pp. 842-845
Author(s):  
G M Makhdoomi ◽  
M L Tiku ◽  
K R Beutner ◽  
P L Ogra
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Chronic Hepatitis B ◽  
Surface Antigen ◽  
Hepatitis B Surface Antigen ◽  
Chronic Hepatitis B Virus ◽  
B Virus ◽  
Acute And Chronic Hepatitis ◽  
Surface Antibody

Sera from 99 chronic hepatitis B surface antigen carriers, 12 individuals with acute type B hepatitis, 26 hepatitis B surface antibody-seropositive subjects, and 50 hepatitis B surface antigen, hepatitis B surface antibody-seronegative subjects were evaluated for the presence of serum imunoconglutinis (IKs). The mean serum IK titers of hepatitis B surface antibody-seropositive and hepatitis B virus-seronegative subjects wre 5.3 and 4.9, respectively. The IK titers of subjects with acute and chronic hepatitis B virus infections were 215.4 and 19.1, respectively. These groups also manifested IK titers greater than or equal to > 16 significantly (P < 0.005) more often than controls did. Among chronic hepatitis B surface antigen carriers, high IK titers were associated with low levels of hepatitis B surface antigen. IK titers of individuals chronically infected with hepatitis B virus and having the rheumatoid factor were similar to those of individuals without the rheumatoid factor. Elevated IK titers represent a physiological autoimmune response and may indicate the presence of immune complexes in acute and chronic hepatitis B virus infection.

scholarly journals Hepatitis B Surface Antigen Levels Can Be Used to Rule Out Cirrhosis in Hepatitis B e Antigen-Positive Chronic Hepatitis B: Results From the SONIC-B Study

2020 ◽  
Author(s):  
Milan J Sonneveld ◽  
Bettina E Hansen ◽  
Willem P Brouwer ◽  
Henry L-Y Chan ◽  
Teerha Piratvisuth ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Chronic Hepatitis B ◽  
Surface Antigen ◽  
Hepatitis B Surface Antigen ◽  
Hepatitis B E Antigen ◽  
Significant Fibrosis ◽  
B Virus ◽  
Rule Out

Abstract Background Serum hepatitis B surface antigen (HBsAg) levels correlate with the duration of chronic hepatitis B virus (HBV) infection and may predict the extent of hepatic fibrosis. Methods We analyzed data from the SONIC-B database, which contains data from 8 global randomized trials and 2 large hepatology centers. Relationship between HBsAg levels and presence of significant fibrosis (Ishak 3–4) or cirrhosis (Ishak 5–6) were explored, and clinically relevant cutoffs were identified to rule out cirrhosis. Results The dataset included 2779 patients: 1866 hepatitis B e antigen (HBeAg)-positive; 322 with cirrhosis. Among HBeAg-positive patients, lower HBsAg levels were associated with higher rates of significant fibrosis (odds ratio [OR], 0.419; P &lt; .001) and cirrhosis (OR, 0.435; P &lt; .001). No relationship was observed among HBeAg-negative patients. Among HBeAg-positive patients, genotype-specific HBsAg cutoffs had excellent negative predictive values (&gt;97%) and low misclassification rates (≤7.1%) and may therefore have utility in ruling out cirrhosis. Diagnostic performance of the HBsAg cutoffs was comparable among patients in whom cirrhosis could not be ruled out with fibrosis 4 (FIB-4). Conclusions Hepatitis B virus genotype-specific HBsAg cutoffs may have utility in ruling out presence of cirrhosis in HBeAg-positive patients with genotypes B, C, and D and can be an adjunct to FIB-4 to reduce the need for further testing.

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