PROLACTIN IN CHILDHOOD OBSESSIVE-COMPULSIVE DISORDER: CLINICAL CORRELATES AND RESPONSE TO CLOMIPRAMINE

PEDIATRICS ◽  
1991 ◽  
Vol 88 (5) ◽  
pp. 992-992
Author(s):  
Gregory L. Hanna ◽  
James T. MCCracken ◽  
Dennis P. Cantwell
Keyword(s):  
Obsessive Compulsive Disorder ◽  
Obsessive Compulsive ◽  
Tic Disorder ◽  
Obsessive Compulsive Symptoms ◽  
Compulsive Disorder ◽  
Serotonergic Receptors ◽  
Duration Of Illness ◽  
Chronic Tic Disorder ◽  
History Of ◽  
Clomipramine Treatment

Basal prolactin concentrations were measured before treatment in 18 children and adolescents with obsessive-compulsive disorder as well as in 15 of these patients after 4 and 8 weeks of clomipramine treatment. Basal prolactin levels were influenced by a history of chronic tic disorder and by the duration and severity of obsessive-compulsive symptoms. Clomipramine administration significantly increased basal prolactin levels. A slight decline in prolactin levels during the last 4 weeks of clomipramine treatment was positively correlated with a favorable treatment response and negatively correlated with duration of illness. If the changes in prolactin levels observed during clomipramine treatment are due primarily to changes in serotonergic neurotransmission, these data suggest that clomipramine treatment of obsessive-compulsive disorder produces an adaptive decrease in the responsiveness of serotonergic receptors.

Obsessive–Compulsive Disorder with and without a Chronic Tic Disorder

1994 ◽  
Vol 164 (4) ◽  
pp. 469-473 ◽  
Author(s):  
Jacob C. Holzer ◽  
Christopher J. McDougle ◽  
Beth K. Boyarsky ◽  
Lawrence H. Price ◽  
Wayne K. Goodman ◽  
...  
Keyword(s):  
Obsessive Compulsive Disorder ◽  
Function Analysis ◽  
Symptom Checklist ◽  
Obsessive Compulsive ◽  
Tic Disorder ◽  
Compulsive Disorder ◽  
Lifetime History ◽  
Chronic Tic Disorder ◽  
History Of ◽  
Age And Sex

The phenomenological features of 35 obsessive–compulsive disorder (OCD) patients with a lifetime history of tics were compared to 35 age- and sex-matched OCD patients without tics. Seven categories of obsessions and nine categories of compulsions were determined using the symptom checklist of the Yale–Brown Obsessive–Compulsive Scale (YBOCS). Discriminant function analysis revealed that, compared to their counterparts without tics, OCD patients with tics had more touching, tapping, rubbing, blinking and staring rituals, and fewer cleaning rituals, but did not differ on obsessions. These preliminary findings suggest that the types of compulsions present may help to discriminate between two putative subgroups of OCD, i.e. those with and without tics.

Obsessive-compulsive disorder in youth with and without a chronic tic disorder

2008 ◽  
Vol 25 (9) ◽  
pp. 761-767 ◽  
Author(s):  
Eric A. Storch ◽  
David Stigge-Kaufman ◽  
Wendi E. Marien ◽  
Muhammad Sajid ◽  
Marni L. Jacob ◽  
...  
Keyword(s):  
Obsessive Compulsive Disorder ◽  
Obsessive Compulsive ◽  
Tic Disorder ◽  
Compulsive Disorder ◽  
Chronic Tic Disorder

Progress toward analysis of D8/17 binding to B cells in children with obsessive compulsive disorder and/or chronic tic disorder

2001 ◽  
Vol 120 (1-2) ◽  
pp. 146-151 ◽  
Author(s):  
Tanya K Murphy ◽  
Neal Benson ◽  
Annette Zaytoun ◽  
Mark Yang ◽  
Raul Braylan ◽  
...  
Keyword(s):  
B Cells ◽  
Obsessive Compulsive Disorder ◽  
Obsessive Compulsive ◽  
Tic Disorder ◽  
Compulsive Disorder ◽  
Chronic Tic Disorder

scholarly journals Comorbidity of Obsessive-Compulsive Disorder and Schizophrenia in an Adolescent

2015 ◽  
Vol 2015 ◽  
pp. 1-3
Author(s):  
Ahmad Nabil Md. Rosli ◽  
Wan Salwina Wan Ismail
Keyword(s):  
Obsessive Compulsive Disorder ◽  
Obsessive Compulsive ◽  
Obsessive Compulsive Symptoms ◽  
Compulsive Disorder ◽  
History Of

We report a case of a girl with a history of obsessive-compulsive disorder (OCD) subsequently exhibiting psychosis. She never attained remission since the outset. Initially she seemed to be resistant to most antipsychotics, namely, risperidone, haloperidol, paliperidone, quetiapine, and clozapine. However, she later responded remarkably better to risperidone after it was reintroduced for the second time. Recognizing and understanding the various pathogenesis of OCD or obsessive-compulsive symptoms (OCS) in schizophrenia are vital in laying out plan to manage the patient effectively.

A Follow-Up of Adolescents with Obsessive-Compulsive Disorder

1989 ◽  
Vol 154 (6) ◽  
pp. 829-834 ◽  
Author(s):  
M. Allsopp ◽  
C. Verduyn
Keyword(s):  
Obsessive Compulsive Disorder ◽  
Psychiatric Illness ◽  
Response To Therapy ◽  
Initial Contact ◽  
Obsessive Compulsive ◽  
Obsessive Compulsive Symptoms ◽  
Compulsive Disorder ◽  
Outcome Information ◽  
History Of

Twenty-six patients seen at a regional adolescent psychiatry unit between 1974 and 1979 with a discharge diagnosis of obsessive-compulsive disorder were followed up after an average of ten years. Of 24 subjects traced, outcome information was obtained from 20. At the point of follow-up, ten patients remained psychiatrically ill, six having persisting obsessive–compulsive symptoms. Poor outcome was associated with a family history of psychiatric illness and lack of response to therapy at initial contact. All patients who were asymptomatic at discharge had remained well.

scholarly journals WISC-IV performance of children with Chronic Tic Disorder, Obsessive–Compulsive Disorder and Attention-Deficit/Hyperactivity Disorder: results from a German clinical study

2021 ◽  
Vol 15 (1) ◽  
Author(s):  
Sina Wanderer ◽  
Veit Roessner ◽  
Anja Strobel ◽  
Julia Martini
Keyword(s):  
Attention Deficit Hyperactivity Disorder ◽  
Obsessive Compulsive Disorder ◽  
Attention Deficit ◽  
Obsessive Compulsive ◽  
Tic Disorder ◽  
Children With Adhd ◽  
Compulsive Disorder ◽  
Hyperactivity Disorder ◽  
Chronic Tic Disorder ◽  
New Findings

Abstract Background Chronic Tic Disorder (CTD), Obsessive–Compulsive Disorder (OCD) and Attention-Deficit/Hyperactivity Disorder (ADHD) are complex neuropsychiatric disorders that frequently co-occur. The aim of this study was to examine WISC-IV performance of a clinical cohort of children with CTD, OCD and/or ADHD. Methods N = 185 children aged 6 to 17 years from Germany with CTD, OCD and/or ADHD were examined with the WISC-IV that comprises four index scores (VCI: Verbal Comprehension Index, PRI: Perceptual Reasoning Index, WMI: Working Memory Index, PSI: Processing Speed Index) and a Full Scale Intelligence Quotient (FSIQ). WISC-IV profiles of children with CTD-only, OCD-only, ADHD-only, CTD+ADHD, CTD+OCD and CTD+OCD+ADHD were compared with the WISC-IV norm (N = 1650, M = 100 and SD = 15) and among each other. Results Unpaired t-tests revealed that children with ADHD-only showed significant lower PSI scores, whereas children with CTD-only and OCD-only had significant higher VCI scores as compared to the German WISC-IV norm. One-way ANOVA revealed that children with ADHD-only showed significant lower WMI scores as compared to children with CTD+OCD. Conclusions We were able to confirm previous evidence on WISC-IV profiles in ADHD in a German clinical sample and contribute new findings on cognitive performance in children with (non-)comorbid CTD and OCD that have to be seen in light of the study’s limitations.

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