Multidetector-row Computed Tomography in the Assessment of Coronary Artery Disease – New Techniques and Insights

2010 ◽  
Vol 6 (2) ◽  
pp. 43 ◽  
Author(s):  
Andreas H Mahnken ◽  
Keyword(s):  
Computed Tomography ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Data Acquisition ◽  
Temporal Resolution ◽  
High Temporal Resolution ◽  
Multidetector Row ◽  
Ct Scanners ◽  
Artery Disease ◽  
Cardiac Mdct

Over the last decade, cardiac computed tomography (CT) technology has experienced revolutionary changes and gained broad clinical acceptance in the work-up of patients suffering from coronary artery disease (CAD). Since cardiac multidetector-row CT (MDCT) was introduced in 1998, acquisition time, number of detector rows and spatial and temporal resolution have improved tremendously. Current developments in cardiac CT are focusing on low-dose cardiac scanning at ultra-high temporal resolution. Technically, there are two major approaches to achieving these goals: rapid data acquisition using dual-source CT scanners with high temporal resolution or volumetric data acquisition with 256/320-slice CT scanners. While each approach has specific advantages and disadvantages, both technologies foster the extension of cardiac MDCT beyond morphological imaging towards the functional assessment of CAD. This article examines current trends in the development of cardiac MDCT.

scholarly journals Accuracy of 64-Multidetector-Row Computed Tomography in the Diagnosis of Coronary Artery Disease

2009 ◽  
Vol 18 (4) ◽  
pp. 323-328 ◽  
Author(s):  
Mehraj Sheikh ◽  
AbdelMohsen Ben-Nakhi ◽  
A. Mohemad Shukkur ◽  
Tariq Sinan ◽  
Ibrahim Al-Rashdan
Keyword(s):  
Computed Tomography ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Multidetector Row Computed Tomography ◽  
Multidetector Row ◽  
Artery Disease

64-Slice Multidetector-row Computed Tomography in the Diagnosis of Coronary Artery Disease

2012 ◽  
Vol 27 (1) ◽  
pp. 29-35 ◽  
Author(s):  
Josef Matthias Kerl ◽  
U. Joseph Schoepf ◽  
Ralf W. Bauer ◽  
Tuna Tekin ◽  
Philip Costello ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Multidetector Row Computed Tomography ◽  
Multidetector Row ◽  
Artery Disease

Abstract 4175: Quantitative Assessment of Myocardial Blood Flow Using Adenosine Triphosphate Stress Multidetector-row Computed Tomography in Coronary Artery Disease

Circulation ◽  
2008 ◽  
Vol 118 (suppl_18) ◽  
Author(s):  
Fumiaki Shikata ◽  
Hiroshi Imagawa ◽  
Teruhito Kido ◽  
Akira Kurata ◽  
Hiroshi Higashino ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Coronary Artery Disease ◽  
Blood Flow ◽  
Coronary Artery ◽  
Myocardial Perfusion ◽  
Myocardial Blood Flow ◽  
Adenosine Triphosphate ◽  
Multidetector Row Computed Tomography ◽  
Multidetector Row ◽  
Artery Disease

Introduction: The purpose of this study was to test the hypothesis that cardiac multidetector-row computed tomography (MDCT) technology can assess myocardial perfusion quantitatively using adenosine triphosphate (ATP) load technique. Methods: Ten patients (median age 71 (range 65–79) years) who were scheduled for surgical revascularization, underwent cardiac electrocardiography-gated MDCT using ATP-load technique. The patients with unstable angina and myocardial infraction were excluded. Myocardial infarction was detected by late gadolinium enhancement MRI which was assessed before MDCT. Myocardial blood flow (MBF) was estimated from the slope of the linear regression equation with Patlak plots analysis. MBF results were compared to the presence of stenoses more than 75% on coronary angiography (CAG) and moderate to severe myocardium ischemia on stress thallium-201 myocardial perfusion scintigraphy (MPS). Results: The overall mean MBF was 1.64±0.61 ml/g/min. Mean MBF in territories with stenosis on CAG was 0.81±0.49 ml/g/min, while mean MBF in territories without stenosis was 1.83±0.64 ml/g/min (p<0.01). Mean MBF in territories with moderate to severe ischemia on MPS was 0.76±0.49 ml/g/min, while mean MBF in territories without ischemia was 2.15±0.66ml/g/min (p<0.01). When the cut off value of MBF was set at 1.5 ml/g/min, there was good correlation between MBF vs CAG, and MBF and MPS. MBF vs CAG: sensitivity=71.4%, specificity=82.6%; MBF vs MPS: sensitivity=85.7%, specificity=87.0%. Conclusions: This study proposed the possibility of MDCT to quantify myocardial blood flow using ATP in coronary artery disease. Our data suggested that the ATP stress MDCT has an advantage in the assessment of CAD to evaluate both coronary artery stenoses and myocardial perfusion information in one modality.

Deformation Measurements by Echocardiography versus Late Enhancement Magnetic Resonance Imaging in Patients with Coronary Artery Disease

2012 ◽  
Vol 8 (2) ◽  
pp. 101
Author(s):  
Brage H Amundsen ◽  
Anders Thorstensen ◽  
Asbjørn Støylen ◽  
◽  
◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Magnetic Resonance ◽  
Late Enhancement ◽  
High Temporal Resolution ◽  
Resonance Imaging ◽  
Deformation Imaging ◽  
Artery Disease ◽  
Deformation Measurements

The aim of this article is to discuss the present and future potential of deformation imaging by echocardiography and scar visualisation by magnetic resonance imaging (MRI) in patients with coronary artery disease (CAD). The two methods are clearly different: one is concerned with function, the other with morphology. Echocardiography, with its versatility of methods and high applicability, will continue to be the workhorse in cardiac imaging of patients with CAD. Important additional information can be extracted from deformation imaging methods, especially due to the high temporal resolution in tissue Doppler. Deformation measurements in 3D images are still limited by their lower resolution compared with 2D but will continue to improve. The standardisation of image analysis and the collaboration within the echocardiographic community to conduct larger studies will be important tasks in the attempt to establish evidence for the new methods. Late enhancement MRI is a method with unique properties and will continue to be an important alternative in selected patients and settings, as well as an invaluable research tool.

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